SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Chanock S) "

Sökning: WFRF:(Chanock S)

  • Resultat 61-70 av 275
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
61.
  •  
62.
  •  
63.
  •  
64.
  •  
65.
  •  
66.
  •  
67.
  •  
68.
  • Berndt, Sonja I., et al. (författare)
  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
  • 2013
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
  • Tidskriftsartikel (refereegranskat)abstract
    • Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
  •  
69.
  • Conti, David, V, et al. (författare)
  • Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
  • 2021
  • Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
  • Tidskriftsartikel (refereegranskat)abstract
    • Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
  •  
70.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 61-70 av 275
Typ av publikation
tidskriftsartikel (264)
konferensbidrag (8)
annan publikation (2)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (253)
övrigt vetenskapligt/konstnärligt (22)
Författare/redaktör
Chanock, SJ (121)
Giles, GG (101)
Easton, DF (101)
Chanock, Stephen J (95)
Haiman, CA (91)
Southey, MC (88)
visa fler...
Chang-Claude, J (85)
Dunning, AM (82)
Brenner, H (79)
Hall, P (79)
Le Marchand, L (76)
Kraft, P (76)
Milne, RL (75)
Garcia-Closas, M (75)
Pharoah, PDP (75)
Fasching, PA (74)
Hopper, JL (73)
Czene, K (72)
Hunter, DJ (72)
Beckmann, MW (71)
Nevanlinna, H (69)
Chenevix-Trench, G (69)
Couch, FJ (67)
Mannermaa, A (67)
Lubinski, J (67)
Kraft, Peter (66)
Hamann, U (65)
Bojesen, SE (65)
Schmidt, MK (64)
Nordestgaard, BG (64)
Benitez, J. (63)
Dork, T (63)
Dennis, J (62)
Cox, A (62)
Lambrechts, D (62)
Andrulis, IL (60)
Zheng, W. (59)
Margolin, S (58)
Devilee, P (58)
Anton-Culver, H (57)
Peto, J (57)
Lindblom, A (56)
Albanes, Demetrius (56)
Brauch, H (56)
Jakubowska, A (56)
Bolla, MK (55)
Blomqvist, C (54)
Burwinkel, B (54)
Radice, P (53)
Truong, T (53)
visa färre...
Lärosäte
Karolinska Institutet (220)
Uppsala universitet (87)
Umeå universitet (83)
Lunds universitet (72)
Göteborgs universitet (16)
Handelshögskolan i Stockholm (2)
visa fler...
Högskolan Dalarna (2)
Örebro universitet (1)
Linköpings universitet (1)
Chalmers tekniska högskola (1)
visa färre...
Språk
Engelska (275)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (158)
Naturvetenskap (5)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy