| 91. |
- Lundell, LS, et al.
(författare)
-
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
- 2020
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4643-
-
Tidskriftsartikel (refereegranskat)abstract
- Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day−1) and extended feeding (EXF, 15 h day−1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression.
|
|
| 92. |
|
|
| 93. |
- Palliyaguru, N. T., et al.
(författare)
-
VLBI Observations of Supernova PTF11qcj: Direct Constraints on the Size of the Radio Ejecta
- 2021
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 910:1
-
Tidskriftsartikel (refereegranskat)abstract
- We present High Sensitivity Array and enhanced Multi-Element Remotely Linked Interferometer Network observations of the radio-loud broad-lined Type Ic supernova PTF11qcj obtained similar to 7.5 yr after the explosion. Previous observations of this supernova at 5.5 yr since explosion showed a double-peaked radio light curve accompanied by a detection in the X-rays, but no evidence for broad H alpha spectral features. The Very Long Baseline Interferometry (VLBI) observations presented here show that the PTF11qcj GHz radio ejecta remains marginally resolved at the submilliarcsecond level 7.5 yr after the explosion, pointing toward a nonrelativistic expansion. Our VLBI observations thus favor a scenario in which the second peak of the PTF11qcj radio light curve is related to the strong interaction of the supernova ejecta with a circumstellar medium of variable density, rather than to the emergence of an off-axis jet. Continued VLBI monitoring of PTF11qcj in the radio may further strengthen this conclusion.
|
|
| 94. |
|
|
| 95. |
|
|
| 96. |
|
|
| 97. |
- Torre, A., et al.
(författare)
-
Conclusion
- 2021
-
Ingår i: Smart Development for Rural Areas. - Abingdon, Oxon; New York, NY: Routledge, 2020. | Series: Regions and cities ; 143 : Taylor & Francis. - 9781000066999 - 9780367374792 ; , s. 213-
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Amenities - as place specific assets and services that make a given location more or less attractive to individuals and firms - deserve attention in the context of policies intended to promote smart development in rural areas. The literature highlights that rural areas lack the necessary resources and levers to foster growth and innovation; levers and resources found in metropolitan areas and in some medium-sized towns. Local entrepreneurs in rural areas can be encouraged to “borrow size” - and with it, knowledge - in several ways, among which the most standard are direct subsidies or tax incentives for R&D. The main characteristics of rural areas are the geographical distance separating individuals and villages from one another, on the one hand, and their lower density on the other. Digital connectivity and improved digital skills increase the attractiveness of rural areas especially for young and qualified people.
|
|
| 98. |
- Torre, A., et al.
(författare)
-
Conclusion
- 2021
-
Ingår i: Smart Development for Rural Areas. - Abingdon, Oxon; New York, NY: Routledge, 2020. | Series: Regions and cities ; 143 : Taylor and Francis.
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Amenities - as place specific assets and services that make a given location more or less attractive to individuals and firms - deserve attention in the context of policies intended to promote smart development in rural areas. The literature highlights that rural areas lack the necessary resources and levers to foster growth and innovation; levers and resources found in metropolitan areas and in some medium-sized towns. Local entrepreneurs in rural areas can be encouraged to “borrow size” - and with it, knowledge - in several ways, among which the most standard are direct subsidies or tax incentives for R&D. The main characteristics of rural areas are the geographical distance separating individuals and villages from one another, on the one hand, and their lower density on the other. Digital connectivity and improved digital skills increase the attractiveness of rural areas especially for young and qualified people.
|
|
| 99. |
- Torre, A., et al.
(författare)
-
Introduction : Is there a smart development for rural areas?
- 2021
-
Ingår i: Smart Development for Rural Areas. - Abingdon, Oxon; New York, NY: Routledge, 2020. | Series: Regions and cities ; 143 : Informa UK Limited. - 9781000066999 - 9780367374792 ; , s. 1-26
-
Bokkapitel (refereegranskat)abstract
- Rural regions have traditionally been dominated by areal industries such as agriculture and forestry, i.e. industries that, for over a century, have been characterized by shrinking employment numbers. Agriculture is traditionally one of the most important economic activities in rural areas and the concept of Smart Agriculture has been included in the European Union growth strategy Horizon 2020, related to the goals of smart, sustainable and inclusive growth. The implementation of smart development strategies in rural areas must take into account the specificities of innovation models and the types of resources available in these territories. For firms in rural regions, knowledge acquisition and dissemination seldom take place through collaboration with universities and research institutes, but rather with other types of organizations and firms. The supply of nature- and culture-based amenities seems relatively more important in explaining new firm formation in rural regions, compared to urban regions. The chapter also presents an overview on the key concepts discussed in this book.
|
|
| 100. |
- Torre, A., et al.
(författare)
-
Smart development for rural areas
- 2021
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- This thought-provoking book questions the framework of the Horizon 2020 strategy and the policies of smart development. It aims to answer the following question: Is there any possibility for a policy of smart development and smart specialization in rural and peri-urban areas? Based on detailed analytical studies, empirical and econometric methods, as well as various European case studies, several conclusions are drawn. Smart development policies are well adapted to the developed or intermediate regions containing at the same time rural and urban areas, but do not really function for the more rural or more peripheral regions. The development policies of rural areas must be adapted to their particular characteristics, to the structure of their economies (agriculture, small firms), as well as in their diversity (distant regions, intermediate regions, rural areas near the urban areas). It appears interesting to exploit natural and cultural amenities, to develop the multifunctional character of the agriculture, to promote territorial innovation under all its forms, to favor the synergies between the various uses of land and space, and to develop the knowledge on the ecological, socioeconomic processes, as well as on the mechanisms of territorial governance. These results are very important because they question the validity of the H2020 policy and the smart development and smart specialization policies and their applicability to the whole European area, and not only for the most urban and rich areas. It will be valuable reading for students, researchers and policy-makers in regional development, rural studies, spatial planning and economic geography.
|
|
