SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Corvin A) "

Search: WFRF:(Corvin A)

  • Result 71-75 of 75
Sort/group result
   
EnumerationReferenceCoverFind
71.
  •  
72.
  • O'Dushlaine, Colm, et al. (author)
  • Genes predict village of origin in rural Europe
  • 2010
  • In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 18:11, s. 1269-1270
  • Journal article (peer-reviewed)abstract
    • The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8-30 km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals.
  •  
73.
  • Ormond, Cathal, et al. (author)
  • Whole genome sequencing study of identical twins discordant for psychosis
  • 2024
  • In: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 14:1
  • Journal article (peer-reviewed)abstract
    • Monozygotic (MZ) twins are often thought to have identical genomes, but recent work has shown that early post-zygotic events can result in a spectrum of DNA variants that are different between MZ twins. Such variants may explain phenotypic discordance and contribute to disease etiology. Here we performed whole genome sequencing in 17 pairs of MZ twins discordant for a psychotic disorder (schizophrenia, schizoaffective disorder or bipolar disorder). We examined various classes of rare variants that are discordant within a twin pair. We identified four genes harboring rare, predicted deleterious missense variants that were private to an affected individual in the cohort. Variants in FOXN1 and FLOT2 would have been categorized as damaging from recent schizophrenia and bipolar exome sequencing studies. Additionally, we identified four rare genic copy number variants (CNVs) private to an affected sample, two of which overlapped genes that have shown evidence for association with schizophrenia or bipolar disorder. One such CNV was a 3q29 duplication previously implicated in autism and developmental delay. We have performed the largest MZ twin study for discordant psychotic phenotypes to date. These findings warrant further investigation using other analytical approaches.
  •  
74.
  •  
75.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 71-75 of 75

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view