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51.	Yoneyama, Sachiko, et al. (författare) Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations 2014 Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:9, s. 2498-2510 Tidskriftsartikel (refereegranskat)abstract Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up to 57 412 individuals of European descent from 22 cohorts collaborating with the NHLBIs Candidate Gene Association Resource (CARe) project. The study population consisted of women and men aged 2080 years. Study participants were genotyped using the ITMAT/Broad/CARE array, which includes 50 000 cosmopolitan tagged SNPs across 2100 cardiovascular-related genes. Each trait was modeled as a function of age, study site and principal components to control for population stratification, and we conducted a fixed-effects meta-analysis. No new loci for WC were observed. For WHR analyses, three novel loci were significantly associated (P 2.4 10(6)). Previously unreported rs2811337-G near TMCC1 was associated with increased WHR ( SE, 0.048 0.008, P 7.7 10(9)) as was rs7302703-G in HOXC10 ( 0.044 0.008, P 2.9 10(7)) and rs936108-C in PEMT ( 0.035 0.007, P 1.9 10(6)). Sex-stratified analyses revealed two additional novel signals among females only, rs12076073-A in SHC1 ( 0.10 0.02, P 1.9 10(6)) and rs1037575-A in ATBDB4 ( 0.046 0.01, P 2.2 10(6)), supporting an already established sexual dimorphism of central adiposity-related genetic variants. Functional analysis using ENCODE and eQTL databases revealed that several of these loci are in regulatory regions or regions with differential expression in adipose tissue.
52.	Zanchetti, Alberto, et al. (författare) Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. 2014 Ingår i: Journal of Hypertension. - 1473-5598. ; 32:9, s. 1888-1897 Tidskriftsartikel (refereegranskat)abstract The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design.
53.	Zanchetti, Alberto, et al. (författare) Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence. 2014 Ingår i: Journal of Hypertension. - 1473-5598. ; 32:9, s. 1741-1750 Forskningsöversikt (refereegranskat)abstract It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.
54.	Zanchetti, Alberto, et al. (författare) Continuation of the ESH-CHL-SHOT trial after publication of the SPRINT: rationale for further study on blood pressure targets of antihypertensive treatment after stroke. 2016 Ingår i: Journal of Hypertension. - 1473-5598. ; 34:3, s. 393-396 Tidskriftsartikel (refereegranskat)

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Typ av publikation: tidskriftsartikel (51); forskningsöversikt (3)

Typ av innehåll: refereegranskat (53); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Dominiczak, Anna F. (27); Melander, Olle (25); Samani, Nilesh J. (25); Padmanabhan, Sandosh (23); Caulfield, Mark J. (21); Munroe, Patricia B. (20); visa fler...; Laurent, Stephane (18); Cifkova, Renata (17); van der Harst, Pim (16); Narkiewicz, Krzyszto ... (16); Wareham, Nicholas J. (15); Farrall, Martin (15); Johnson, Toby (15); Viigimaa, Margus (15); Redon, Josep (15); Loos, Ruth J F (14); Boerwinkle, Eric (13); McCarthy, Mark I (12); Luan, Jian'an (12); Elliott, Paul (12); Asselbergs, Folkert ... (12); Fagard, Robert (12); Salomaa, Veikko (11); Deloukas, Panos (11); Gieger, Christian (11); Jarvelin, Marjo-Riit ... (11); Sever, Peter (11); Watkins, Hugh (11); Zhang, Weihua (11); Nilsson, Peter (10); Soranzo, Nicole (10); Rudan, Igor (10); Boehnke, Michael (10); Connell, John M. (10); Hayward, Caroline (10); Tobin, Martin D (10); Delles, Christian (10); De Backer, Guy (10); van Duijn, Cornelia ... (9); Langenberg, Claudia (9); Mohlke, Karen L (9); Verweij, Niek (9); Rotter, Jerome I. (9); Spector, Timothy D (9); Kooperberg, Charles (9); Lawlor, Debbie A (9); Gaunt, Tom R. (9); Illig, Thomas (9); Schlessinger, David (9); Snieder, Harold (9); visa färre...

Lärosäte: Lunds universitet (42); Uppsala universitet (14); Karolinska Institutet (13); Umeå universitet (12); Göteborgs universitet (5); Linköpings universitet (3); visa fler...; Linnéuniversitetet (1); Högskolan Dalarna (1); Sveriges Lantbruksuniversitet (1); visa färre...

Språk: Engelska (53); Italienska (1)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (46); Naturvetenskap (1)

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