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| 23. |
- Diez, Paula, et al.
(författare)
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Integration of Proteomics and Transcriptomics Data Sets for the Analysis of a Lymphoma B-Cell Line in the Context of the Chromosome-Centric Human Proteome Project
- 2015
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 14:9, s. 3530-3540
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Tidskriftsartikel (refereegranskat)abstract
- A comprehensive study of the molecular active landscape of human cells can be undertaken to integrate two different but complementary perspectives: transcriptomics, and proteomics. After the genome era, proteomics has emerged as a powerful tool to simultaneously identify and characterize the compendium of thousands of different proteins active in a cell. Thus, the Chromosome-centric Human Proteome Project (C-HPP) is promoting a full characterization of the human proteome combining high-throughput proteomics with the data derived from genome-wide expression profiling of protein-coding genes. Here we present a full proteomic profiling of a human lymphoma B-cell line (Ramos) performed using a nanoUPLC-LTQ-Orbitrap Velos proteomic platform, combined to an in-depth transcriptomic profiling of the same cell type. Data are available via ProteomeXchange with identifier PXD001933. Integration of the proteomic and transcriptomic data sets revealed a 94% overlap in the proteins identified by both -omics approaches. Moreover, functional enrichment analysis of the proteomic profiles showed an enrichment of several functions directly related to the biological and morphological characteristics of B-cells. In turn, about 30% of all protein-coding genes present in the whole human genome were identified as being expressed by the Ramos cells (stable average of 30% genes along all the chromosomes), revealing the size of the protein expression-set present in one specific human cell type. Additionally, the identification of missing proteins in our data sets has been reported, highlighting the power of the approach. Also, a comparison between neXtProt and UniProt database searches has been performed. In summary, our transcriptomic and proteomic experimental profiling provided a high coverage report of the expressed proteome from a human lymphoma B-cell type with a clear insight into the biological processes that characterized these cells. In this way, we demonstrated the usefulness of combining -omics for a comprehensive characterization of specific biological systems.
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| 24. |
- Droste, S., et al.
(författare)
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Finite-frequency noise in a quantum dot with normal and superconducting leads
- 2015
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Ingår i: Physical Review B - Condensed Matter and Materials Physics. - 2469-9950 .- 2469-9969. ; 91:12, s. Art. no. 125401-
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Tidskriftsartikel (refereegranskat)abstract
- We consider a single-level quantum dot tunnel-coupled to one normal and one superconducting lead. We employ a diagrammatic real-time approach to calculate the finite-frequency current noise for subgap transport. The noise spectrum gives direct access to the internal dynamics of the dot. In particular, the noise spectrum shows sharp dips at the frequency of the coherent oscillations of Cooper pairs between the dot and the superconductor. This feature is most pronounced when the superconducting correlation is maximal. Furthermore, in the quantum-noise regime, omega > k(B)T, mu(N), the noise spectrum exhibits steps at frequencies equal to the Andreev addition energies. The height of these steps is related to the effective coupling strength of the excitations. The finite-frequency noise spectrum hence provides a full spectroscopy of the system.
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| 25. |
- Krause, M. S., et al.
(författare)
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Survey data on voluntary nature conservation commitments of German businesses and their perceptions towards conservation credits
- 2020
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Ingår i: Data in Brief. - : Elsevier BV. - 2352-3409. ; 33
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Tidskriftsartikel (refereegranskat)abstract
- To preserve biodiversity and ecosystem services, company engagement is crucial. However, available data on manager views and perceptions regarding nature conservation in particular is rare. The presented survey data gives insights into current levels and forms of business commitments for nature conservation. The data contributes to understanding business attitudes towards voluntary conservation action and includes information about factors that influence their engagement. Moreover, the data informs about manager perceptions towards the concept of nature conservation credits and, as such, allows for an evaluation of a certified biodiversity and ecosystem services market. Importantly, the dataset contains essential company characteristics to put responses into greater context. The scope of the survey is limited to German companies from secondary and tertiary sectors. Companies were sampled through proportional stratified random sampling based on size and location. The data was collected through a self-administered online-survey, conducted in 2019. The database comprises responses of 747 companies that logged into the online system. The survey data were in part analysed through structural equation modelling for an investigation of factors that drive voluntary conservation commitments [1]. Related to this analysis, a subset of 618 companies is available that provided sufficiently completed questionnaires. Both datasets, i.e. the raw data as well as the first subset used for analysis, are hosted in the public repository Open Research Data of the Leibniz Centre for Agricultural Landscape Research (ZALF), Germany. The repository also stores all coding information as well as the questionnaire: https://www.doi.org/10.4228/ZALF.DK.149. The dataset can be used, for example, by researchers from the field of environmental business management and strategy.
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| 26. |
- Litnovsky, A., et al.
(författare)
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Diagnostic mirrors for ITER : A material choice and the impact of erosion and deposition on their performance
- 2007
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Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 363, s. 1395-1402
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Tidskriftsartikel (refereegranskat)abstract
- Metal mirrors will be implemented in about half of the ITER diagnostics. Mirrors in ITER will have to withstand radiation loads, erosion by charge-exchange neutrals, deposition of impurities, particle implantation and neutron irradiation. It is believed that the optical properties of diagnostic mirrors will be primarily influenced by erosion and deposition. A solution is needed for optimal performance of mirrors in ITER throughout the entire lifetime of the machine. A multi-machine research on diagnostic mirrors is currently underway in fusion facilities at several institutions and laboratories worldwide. Among others, dedicated investigations of ITER-candidate mirror materials are ongoing in Tore-Supra, TEXTOR, DIII-D, TCV, T-10 and JET. Laboratory studies are underway at IPP Kharkov (Ukraine), Kurchatov Institute (Russia) and the University of Basel (Switzerland). An overview of current research on diagnostic mirrors along with an outlook on future investigations is the subject of this paper.
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