| 31. |
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| 32. |
- Morin, Samuel, et al.
(author)
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The Mountain Component of the Copernicus Climate Change Services - Sectoral Information Service "European Tourism" : Towards Pan-European Analysis and Projections of Natural and Managed Snow Conditions
- 2018
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In: International Snow Science Workshop Proceedings 2018. - : Montana State University Library.
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Conference paper (peer-reviewed)abstract
- Ski tourism plays a major role in European mountain areas such as the Alps, Pyrenees, Scandinavia, Turkey, Eastern European Mountains etc. Meteorological conditions govern the operating conditions of ski resorts, due to their reliance on natural snow fall and favorable conditions for snowmaking. However, there is currently a major lack of assessment of past and future operating conditions of ski resorts at the pan-European scale in the context of climate change. The presented work aims at filling this gap, as part of the ongoing development of « European Tourism » Sectoral Information Service (SIS) of the Copernicus Climate Change Services (C3S). C3S is run by the European Center for Medium-range Weather Forecast (ECMWF) on behalf of the European Commission. Such an endeavor requires combining state-of-the-art meteorological reanalysis with regional climate projections, followed by the application of a snowpack model accounting for grooming and snowmaking. Emphasis will be placed on the workflow making it possible to analyze the data with various levels of aggregation (from daily data to annual scale indicators, to their statistical moments accounting for multiple climate scenarios and lead times), in order to address the needs of various stakeholders, at the European, national, regional and local scales. The data will be made available freely through the Copernicus Data Store in various ways (download of raw data, download or graphics based on post-processed information accounting for user specific needs). It is expected that the data and the tools developed within this project will not only make it possible to analyze the climate sensitivity of ski tourism in Europe as a topical yet academic research question, but would also help third-parties in developing climate services specifically targeting the ski tourism industry in Europe. This contribution introduces the scientific background and general strategy for generating the products, and delivers preliminary information relevant to this upcoming operational service, planned to open to users from 2019 onwards.
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| 33. |
- Toschi, Nicola, et al.
(author)
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Biomarker-guided clustering of Alzheimer's disease clinical syndromes.
- 2019
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In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 83, s. 42-53
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Journal article (peer-reviewed)abstract
- Alzheimer's disease (AD) neuropathology is extremely heterogeneous, and the evolution from preclinical to mild cognitive impairment until dementia is driven by interacting genetic/biological mechanisms not fully captured by current clinical/research criteria. We characterized the heterogeneous "construct" of AD through a cerebrospinal fluid biomarker-guided stratification approach. We analyzed 5 validated pathophysiological cerebrospinal fluid biomarkers (Aβ1-42, t-tau, p-tau181, NFL, YKL-40) in 113 participants (healthy controls [N= 20], subjective memory complainers [N= 36], mild cognitive impairment [N= 20], and AD dementia [N= 37], age: 66.7 ± 10.4, 70.4 ± 7.7, 71.7 ± 8.4, 76.2 ± 3.5years [mean ± SD], respectively) using Density-Based Spatial Clustering of Applications with Noise, which does not require a priori determination of the number of clusters. We found 5 distinct clusters (sizes: N= 38, 16, 24, 14, and 21) whose composition was independent of phenotypical groups. Two clusters showed biomarker profiles linked to neurodegenerative processes not associated with classical AD-related pathophysiology. One cluster was characterized by the neuroinflammation biomarker YKL-40. Combining nonlinear data aggregation with informative biomarkers can generate novel patient strata which are representative of cellular/molecular pathophysiology and may aid in predicting disease evolution and mechanistic drug response.
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| 34. |
- Vergallo, Andrea, et al.
(author)
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Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers.
- 2018
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 14:12, s. 1623-1631
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Journal article (peer-reviewed)abstract
- Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls.The pathophysiological role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD).We found a positive association between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF α-syn and both CSF t-tau and p-tau181 concentrations.Animal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.
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| 35. |
- Vergallo, Andrea, et al.
(author)
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Plasma β-secretase1 concentrations correlate with basal forebrain atrophy and neurodegeneration in cognitively healthy individuals at risk for AD.
- 2021
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 17:4, s. 629-640
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Journal article (peer-reviewed)abstract
- Increased β-secretase 1 (BACE1) protein concentration, in body fluids, is a candidate biomarker of Alzheimer's disease (AD).We reported that plasma BACE1 protein concentrations are associated with the levels of brain amyloidβ(Αβ) accumulation in cognitively healthy individuals with subjective memory complaint (SMC).In 302 individuals from the same cohort, we investigated the cross-sectional and longitudinal association between plasma BACE1 protein concentrations and AD biomarkers of neurodegeneration (plasma t-tau and Neurofilament light chain (NfL), fluorodeoxyglucose-positron emission tomography (FDG-PET), brain volumes in the basal forebrain [BF], hippocampus, and entorhinal cortex).We report a positive longitudinal correlation of BACE1 with both NfL and t-tau, as well as a correlation between annual BACE1 changes and bi-annual reduction of BF volume. We show a positive association between BACE1 and FDG-PET signal at baseline.The association between plasma BACE1 protein concentrations and BF atrophy we found in cognitively healthy individuals with SMC corroborates translational studies, suggesting a role of BACE1 in neurodegeneration.
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