| 341. |
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| 342. |
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| 343. |
- Vegfors, Jenny, et al.
(författare)
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Psoriasin (S100A7) promotes stress-induced angiogenesis.
- 2016
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Ingår i: British Journal of Dermatology. - : John Wiley & Sons. - 0007-0963 .- 1365-2133. ; 175:6, s. 1263-1273
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Vascular modifications occur early in the development of psoriasis, and angiogenesis is one of the key features in the pathogenesis of the disease.OBJECTIVES: To identify the role of the S100 protein psoriasin in psoriasis-associated angiogenesis.METHODS: The role of psoriasin in mediating angiogenesis was investigated by silencing psoriasin with small interfering RNA (siRNA) and measuring psoriasis-associated angiogenic factors in human epidermal keratinocytes. The secretion of psoriasin and the effect of psoriasin on general regulators of angiogenesis in keratinocytes, and on endothelial cell migration, proliferation, tube formation and production of angiogenic mediators, was evaluated.RESULTS: Reactive oxygen species (ROS) and hypoxia induced the expression of psoriasin. Downregulation of psoriasin in keratinocytes using siRNA altered the ROS-induced expression of the psoriasis-associated angiogenic factors vascular endothelial growth factor (VEGF), heparin-binding epidermal growth factor-like growth factor, matrix metalloproteinase 1 and thrombospondin 1. Overexpression of psoriasin altered several regulators of angiogenesis and led to the secretion of psoriasin. Treatment with extracellular psoriasin induced proliferation, migration and tube formation in dermal-derived endothelial cells to a similar extent as VEGF and interleukin-17, and induced the expression and release of proangiogenic mediators. These effects were suggested to be mediated by the PI3K and nuclear factor kappa B pathways.CONCLUSIONS: These findings suggest that psoriasin expression is promoted by oxidative stress in keratinocytes and amplifies the ROS-induced expression of angiogenic factors relevant to psoriasis. Moreover, extracellularly secreted psoriasin may act on dermal endothelial cells to contribute to key features angiogenesis.
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| 344. |
- Wagers, S, et al.
(författare)
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The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?
- 2004
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Ingår i: Journal of Applied Physiology. - : American Physiological Society. - 1522-1601 .- 8750-7587. ; 96:6, s. 2019-2027
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Tidskriftsartikel (refereegranskat)abstract
- Mice with allergically inflamed airways are widely used as animal models of asthma, but their relevance for human asthma is not understood. We, therefore, examined the time course of changes in respiratory input impedance during induced bronchoconstriction in BALB/c mice sensitized and challenged with ovalbumin. Our results indicate that bronchoconstriction in mice is accompanied by complete closure of substantial regions of the lung and that closure increases markedly when the lungs are allergically inflamed. With the aid of an anatomically accurate computational model of the mouse lung, we show that the hyperresponsiveness of mice with allergically inflamed airways can be explained entirely by a thickening of the airway mucosa and an increased propensity of the airways to close, without the involvement of any increase in the degree of airway smooth muscle shortening. This has implications for the pathophysiology of asthma and suggests that at least some types of asthma may benefit from therapies aimed at manipulating surface tension at the air-liquid interface in the lungs.
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| 345. |
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| 346. |
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| 347. |
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| 348. |
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| 349. |
- Wallstrom, S., et al.
(författare)
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Person-centred care in clinical assessment
- 2018
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Ingår i: Eur J Cardiovasc Nurs. - : Oxford University Press (OUP). - 1474-5151 .- 1873-1953. ; 17:7, s. 576-579
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Tidskriftsartikel (refereegranskat)
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| 350. |
- Wang, Kai, et al.
(författare)
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Extended Calculations of Spectroscopic Data : Energy Levels, Lifetimes, and Transition Rates for O-like Ions from Cr XVII to ZnXXIII
- 2017
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Ingår i: Astrophysical Journal Supplement Series. - : Bibliopolis, Edizioni di Filosofia e Scienze. - 0067-0049 .- 1538-4365. ; 229:2
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Tidskriftsartikel (refereegranskat)abstract
- Employing two state-of-the-art methods, multiconfiguration Dirac-Hartree-Fock and second-order many-body perturbation theory, the excitation energies and lifetimes for the lowest 200 states of the 2 s(2)2p(4), 2s2p(5), 2p(6), 2s(2)2p(3)3s, 2s(2)2p(3)3p, 2s(2)2p(3)3d, 2s(2)p(4)3s, 2s2p(4)3p, and 2s2p(4)3d configurations, and multipole (electric dipole (E1), magnetic dipole (M1), and electric quadrupole (E2)) transition rates, line strengths, and oscillator strengths among these states are calculated for each O-like ion, from Cr XVII to Zn XXIII. Our two data sets are compared with the National Institute of Standards and Technology and CHIANTI compiled values, and previous calculations. The data are accurate enough for identification and deblending of new emission lines from the Sun and other astrophysical sources. The amount of high-accuracy data is significantly increased for the n. =. 3 states of several O-like ions of astrophysical interest, where experimental data are very scarce.
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