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Search: WFRF:(Ekman S)

  • Result 31-40 of 371
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  • Sellgren, C. M., et al. (author)
  • A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
  • 2016
  • In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 21:10, s. 1342-1350
  • Journal article (peer-reviewed)abstract
    • Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we conducted a genome-wide association study based on CSF KYNA in bipolar disorder and found support for an association with a common variant within 1p21.3. After replication in an independent cohort, we linked this genetic variant-associated with reduced SNX7 expression-to positive psychotic symptoms and executive function deficits in bipolar disorder. A series of post-mortem brain tissue and in vitro experiments suggested SNX7 downregulation to result in a caspase-8-driven activation of interleukin-1 beta and a subsequent induction of the brain kynurenine pathway. The current study demonstrates the potential of using biomarkers in genetic studies of psychiatric disorders, and may help to identify novel drug targets in bipolar disorder.
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  • Zamora, Juan Carlos, et al. (author)
  • Considerations and consequences of allowing DNA sequence data as types of fungal taxa
  • 2018
  • In: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
  • Journal article (peer-reviewed)abstract
    • Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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  • Result 31-40 of 371
Type of publication
journal article (272)
conference paper (80)
reports (7)
other publication (6)
book (2)
research review (2)
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editorial collection (1)
book chapter (1)
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Type of content
peer-reviewed (273)
other academic/artistic (97)
pop. science, debate, etc. (1)
Author/Editor
Ekman, S (122)
Tsakonas, G (24)
Ekman, Jörgen (21)
Lewensohn, R. (21)
Brustugun, OT (19)
Ekman, M (17)
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de Petris, L (17)
Ekman, P (17)
Ekman, Annica M. L. (16)
Rudolph, Dirk (15)
Hydbring, P (15)
Bergqvist, M. (13)
Fahlander, Claes (13)
Ekman, Inger, 1952 (13)
Carpenter, M P (12)
Seweryniak, D. (12)
Ekman, J (12)
Ragnarsson, Oskar, 1 ... (11)
Sarantites, D. G. (11)
Rosenlund, M (11)
Ekman-Ordeberg, G (11)
du Rietz, Rickard (10)
Burman, Pia (10)
Olsson, Daniel S, 19 ... (10)
Charity, R. J. (10)
Reviol, W. (10)
Planck, M. (10)
Viktorsson, K. (9)
Dahlqvist, Per (9)
Ekman, Bertil (9)
Eide, IJZ (9)
Andersson, Lise-Lott ... (9)
Ekman, B (9)
Sorensen, JB (9)
Zhu, S. (8)
Landén, Mikael, 1966 (8)
Ragnarsson, Ingemar (8)
Bergstrom, S (8)
Chiara, C. J. (8)
Torres, D. A. (8)
Pechenaya, O. L. (8)
Sobotka, L. G. (8)
Ekman, R (8)
Ekman, A (8)
Riipinen, Ilona (7)
Johannsson, Gudmundu ... (7)
Friesland, S (7)
Johansson, Emma (7)
Patel, D. (7)
Andreoiu, C (7)
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University
Karolinska Institutet (212)
Lund University (57)
University of Gothenburg (49)
Uppsala University (43)
Stockholm University (25)
Linköping University (25)
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Umeå University (19)
Royal Institute of Technology (16)
Örebro University (15)
Mälardalen University (11)
RISE (11)
Malmö University (8)
Chalmers University of Technology (5)
Blekinge Institute of Technology (5)
Swedish University of Agricultural Sciences (4)
Södertörn University (3)
Swedish Museum of Natural History (3)
Karlstad University (2)
Jönköping University (1)
Swedish Environmental Protection Agency (1)
Swedish National Defence College (1)
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Language
English (361)
Swedish (9)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (82)
Natural sciences (58)
Agricultural Sciences (11)
Social Sciences (10)
Engineering and Technology (8)
Humanities (1)

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