| 61. |
- Jenssen, Anders, et al.
(author)
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Effect of bwr environment on the fracture toughness of alloy X-750
- 2013
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In: Environmental Degradation of materials in nuclear power systems. - Houston : NACE International.
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Conference paper (other academic/artistic)abstract
- Fracture toughness testing is normally performed in air on specimens provided with a transgranular pre-crack generated in air by fatigue loading. However, stress corrosion cracks in nuclear power plants are usually intergranular and in contact with reactor coolant. Fracture toughness data used in e.g., flaw tolerance analyses are generated in air with transgranular pre-cracks. Since the effects of the fracture mode of the pre-crack and the reactor coolant on the fracture toughness are not known in detail, it is important to investigate if the data used today are sufficiently conservative. Compact tension (CT) specimens of Alloy X-750 with thickness (B) 9.3 mm and width (W) 18.6 mm were tested under various conditions with the objective to investigate the possible effects of an intergranular pre-crack as well as BWR coolant on the fracture toughness. Three specimens were tested under constant stress intensity (K) in simulated BWR normal water chemistry (NWC) in order to generate an intergranular pre-crack. One specimen was removed from the autoclave and then fracture toughness tested in air at 288 ºC. The other specimens remained in the autoclave in the presence of simulated BWR coolant during the fracture toughness test. For comparison, specimens with a transgranular pre-crack were tested in air at 288 ºC. Neither the fracture mode, nor the BWR coolant appeared to have any adverse effects on the fracture toughness in these tests.
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| 62. |
- Johansson, Björn
(author)
-
Att slåss för erkännande : en studie i gatuvåldets dynamik
- 2001
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Doctoral thesis (other academic/artistic)abstract
- The aim of this thesis is to give a contribution to the knowledge of why people use violence against each other in public places. In more specific terms the thesis examines mechanisms that generates violent actions by reference to what happens in the situated transaction between the offender and the victim, and to the ways in which the urban environment create opportunities for violent actions. In the thesis I address some overall questions to mark of different dimensions of the studied phenomenon. The questions pay attention to: 1) the relation between the physical and social dimensions of the urban environment and the ways in which the urban environment creates opportunities for violent crimes; 2) why the offenders seek themselves to certain places and the symbolic meaning those places has, and; 3) what happens in the situated transactions between the offender and the victim. My methodological approach is multistrategic. The main components of the approach are qualitative interviews, studies of court orders, statistics and geographical studies. I interviewed respondents that have been punished for different crimes of violence committed in public places in the city centre of Örebro. The interviews were complemented with a case study of court orders over street related crimes of violence committed in the same area, and with a statistic and a geographical analyses over where, when and by whom the crimes were committed. The analyses of the ways in which the urban environment creates opportunities for violent crimes reveals some necessary conditions of physical, social and cultural character, i.e. properties of the urban environment that creates good opportunities for street related violence to occur. I started with a statistical examination of where, when and by whom different crimes of violence were committed. With the empirical regularities as a starting-point I began to analyse the urban environment with the help of Bill Hillier’s (1996) concept of virtual community. The analysis reveals that the city centre context of Örebro offer good opportunities for encounters and movements as it contains of several squares and main passages with an open character and good opportunities for orientation. Thus, the physical design of the city centre form a potential for violence to occur. After that I focused on border controls and the potential for violence they include. The importance of border controls were examined in several ways and it was concluded that the border controls contain different dimensions that contribute to the production of violent actions in different ways. This was followed by an examination of the use of the public spaces from the perspective of territoriality and the potential for violence that territories include. It was concluded that the city centre contains of several territories belonging to different categories, and that a distinction could be made between territories established on spontaneous grounds as well as territories established as a result of the activities that exists in a certain area. The analyses of the situated transactions reveal several mechanisms that contribute to the production of violent actions. The analyses started with a statistical examination of the offenders, the victims and the situations that results in violence. With this as a starting-point I began to examine the situated transactions with reference to what happens in the transactions. I found that different kinds of disturbances constitute the initial cause of the process in which an interaction exceeds to violence. Other important aspects that were revealed were the importance of respect and honour for the production of violence and that a distinction could be made between different kinds of violence depending on how the disturbances are interpreted and what it is directed towards. Furthermore, I examined the importance of emotions and social bonds for the production of violence as well as the ways in which different kinds of strategies of action find expression in the situated transactions in public places. Finally the situated transaction were examined from a ritualistic perspective were I found that different kinds of violations of the ritual objects as well as different dimensions of power and status are important for the understanding of the street related violence.
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| 63. |
- Jónsdóttir, Kristín
(author)
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Studies of Unusual Seismicity and Long Period Events at the Glacier Overlain Katla Volcano, Iceland
- 2009
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Doctoral thesis (other academic/artistic)abstract
- Earthquake catalogues are usually dominated by diffusive behaviour consistent with the Omori law of aftershocks. This is investigated in terms of waiting times, i.e. the time between successive events in a time-sorted earthquake catalogue. The theoretical waiting time probability distribution for the Omori law is derived and shown to predict the numerically produced Omori aftershock sequence well. These results enhance our understanding of aftershock processes and demonstrate that previous waiting time interpretations were severely flawed.Iceland earthquake catalogues are studied in terms of waiting times. Omori aftershock sequences are shown to predict most datasets well but there are some significant exceptions. One of these is data from the glacier covered Katla volcano in South Iceland, with few aftershocks. This dataset can be further split into two geographical groups: Several hundred volcano-tectonic earthquakes occurring within the caldera, reaching depths down to 15 km, and thousands of emergent low frequency earthquakes with a poorly defined shallow source in Goðabunga, in the western part of Katla. These events are investigated further.The lp events at Goðabunga have been recorded for decades and show a clear seasonal and climate-related correlation where their number increases in the autumn as well as during warmer years. Many of them form groups with very with similar waveforms. New broad-band seismic data suggests that the lp events originate in a steep outlet glacier covering Katla. Here, ice movement leads to ice falls over the steep escarpment, and we now believe that the lp events are generated by large ice falls rather than being related to gas or magma movements within the volcano, and are not precursors to an eruption as previously suspected. This observation probably has major significance for hazard estimation at the many ice-covered volcanoes around the world.We report near-field (vlp) signals simultaneous with the largest lp events. Our data is partly consistent in character with surface deformation (displacement and tilt) due to the ice movements. However, in line with results from elsewhere, the magnitudes of the observed effects are large relative to those from mathematical modelling. Our analysis suggests that the signal is not an instrumental artefact. Possible explanations are discussed.
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| 64. |
- Landälv, Ludvig, 1982-, et al.
(author)
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Phase evolution of radio frequency magnetron sputtered Cr-rich (Cr,Zr)(2)O-3 coatings studied by in situ synchrotron X-ray diffraction during annealing in air or vacuum
- 2019
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In: Journal of Materials Research. - : CAMBRIDGE UNIV PRESS. - 0884-2914 .- 2044-5326. ; 34:22, s. 3735-3746
-
Journal article (peer-reviewed)abstract
- The phase evolution of reactive radio frequency (RF) magnetron sputtered Cr0.28Zr0.10O0.61 coatings has been studied by in situ synchrotron X-ray diffraction during annealing under air atmosphere and vacuum. The annealing in vacuum shows t-ZrO2 formation starting at similar to 750-800 degrees C, followed by decomposition of the alpha-Cr2O3 structure in conjunction with bcc-Cr formation, starting at similar to 950 degrees C. The resulting coating after annealing to 1140 degrees C is a mixture of t-ZrO2, m-ZrO2, and bcc-Cr. The air-annealed sample shows t-ZrO2 formation starting at similar to 750 degrees C. The resulting coating after annealing to 975 degrees C is a mixture of t-ZrO2 and alpha-Cr2O3 (with dissolved Zr). The microstructure coarsened slightly during annealing, but the mechanical properties are maintained, with no detectable bcc-Cr formation. A larger t-ZrO2 fraction compared with alpha-Cr2O3 is observed in the vacuum-annealed coating compared with the air-annealed coating at 975 degrees C. The results indicate that the studied pseudo-binary oxide is more stable in air atmosphere than in vacuum.
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| 65. |
- Lundberg, Martin, et al.
(author)
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Multiplexed Homogeneous Proximity Ligation Assays for High-throughput Protein Biomarker Research in Serological Material
- 2011
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In: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 10:4, s. M110.004978-
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Journal article (peer-reviewed)abstract
- A high throughput protein biomarker discovery tool has been developed based on multiplexed proximity ligation assays in a homogeneous format in the sense of no washing steps. The platform consists of four 24-plex panels profiling 74 putative biomarkers with sub-pM sensitivity each consuming only 1 mu l of human plasma sample. The system uses either matched monoclonal antibody pairs or the more readily available single batches of affinity purified polyclonal antibodies to generate the target specific reagents by covalently linking with unique nucleic acid sequences. These paired sequences are united by DNA ligation upon simultaneous target binding forming a PCR amplicon. Multiplex proximity ligation assays thereby converts multiple target analytes into real-time PCR amplicons that are individually quantified using microfluidic high capacity qPCR in nano liter volumes. The assay shows excellent specificity, even in multiplex, by its dual recognition feature, its proximity requirement, and most importantly by using unique sequence specific reporter fragments on both antibody-based probes. To illustrate the potential of this protein detection technology, a pilot biomarker research project was performed using biobanked plasma samples for the detection of colorectal cancer using a multivariate signature.
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| 66. |
- Löfdahl, Claes-Göran, et al.
(author)
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COPD health care in Sweden - A study in primary and secondary care
- 2010
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In: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 104:3, s. 404-411
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Journal article (peer-reviewed)abstract
- Objectives: To map out-patients with Chronic Obstructive Pulmonary Disease (COPD) with special reference to patients suffering from acute exacerbations, and to describe COPI) health care structure and process in Swedish clinical. practice in a real life setting. Design: Retrospective, non-interventional, epidemiological survey. Setting: 141 hospital based out patient clinics (OPC, n = 30) and primary health care clinics (PC, n = 111) were included in the structure evaluation. Subjects: 1004 COPI) diagnosed patients from 100 of the centres (OPC, n = 26) participated in the process evaluation. Methods: All Swedish OPC (n = 40) and a random sample of 180 PC were asked to answer a questionnaire regarding COPI) care. In addition, data from 10 randomly selected patients with a documented COPI) disease were analysed from the centres. Results: Spirometers were available at all OPCs and at 99% of the PCs. Spirometry had been performed in 52% of PC-patients and in 89% of OPC-patients during the last 2 years prior to the study. More severe patients, as judged by investigator and lung function data, were treated at OPCs than at PCs. Physiotherapists, occupational therapists and dieticians were available at >80% of centres. Exacerbation rate was higher at PCs without a specialized nurse, 2.2/year versus 0.9/year at centres with a specialized nurse. Conclusions: Special attention to COPD, marked by a specialised nurse in primary care improves the quality, as assessed by a tower number of exacerbations. The structure of COPD care in Sweden for diagnosed individuals seems satisfactory, but could be improved mainly through higher availability and educational activities.
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| 67. |
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| 68. |
- Löfqvist, Charlotte, et al.
(author)
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Use, non-use and perceived unmet needs of assistive technology among Swedish people in the third age.
- 2016
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In: Disability and rehabilitation. Assistive technology. - : Informa UK Limited. - 1748-3115 .- 1748-3107. ; 11:3, s. 195-201
-
Journal article (peer-reviewed)abstract
- Abstract Purpose: To describe the most prominent use of or perceived unmet need of assistive technology (AT) and to compare the characteristics of users, non-users and those expressing perceived unmet need with respect to overall health, independence in everyday life, environmental barriers and socio-demographic features. Method: The study is based on data collected in the "Home and Health in the Third Age Project". In all, 371 individuals participated and data were collected during home visits in southern Sweden by interviewers trained specifically for this project. The data collection comprised well-proven self-report scales and observational formats on the home environment and health indicators as well as questions about basic demographics and socio-structural data. Results: The proportion of users constituted almost half of the total sample. The most common types of AT used were for furnishing/adaptation (35%) and the highest perceived unmet need concerned AT for communication, in total 8%. Those cohabiting were to a higher extent users of AT for furnishing/adaptation, compared to those who lived alone. A higher perceived unmet need was seen among those who lived alone compared with cohabiting people. Conclusions: These findings are of importance for future planning and development of policy to improve health services for the new generation of elderly. Implications for Rehabilitation In order to support the ageing process, the need for assistive technology has to be monitored in the third age. Assistive technology for furnishings and adaptation are frequently used by individuals in their third age and are important to support ageing in the home. Not only do health aspects impact the use of assistive technology, but gender, living conditions and social situation also matter - older men especially need to be monitored thoroughly according to their perceived unmet needs as well as do older persons living alone.
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| 69. |
- Mezheyeuski, Artur, et al.
(author)
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
- 2023
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In: EBioMedicine. - : Elsevier. - 2352-3964. ; 88
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Journal article (peer-reviewed)abstract
- Background: Cancer immunity is based on the interaction of a multitude of cells in the spatial context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated to fundamentally improve the accuracy in predicting disease progression.Methods: Through a multiplex in situ analysis we evaluated 15 immune cell classes in 1481 tumour samples. Single-cell and bulk RNAseq data sets were used for functional analysis and validation of prognostic and predictive associations.Findings: By combining the prognostic information of anti-tumoural CD8+ lymphocytes and tumour supportive CD68+CD163+ macrophages in colorectal cancer we generated a signature of immune activation (SIA). The prognostic impact of SIA was independent of conventional parameters and comparable with the state-of-art immune score. The SIA was also associated with patient survival in oesophageal adenocarcinoma, bladder cancer, lung adenocarcinoma and melanoma, but not in endometrial, ovarian and squamous cell lung carcinoma. We identified CD68+CD163+ macrophages as the major producers of complement C1q, which could serve as a surrogate marker of this macrophage subset. Consequently, the RNA-based version of SIA (ratio of CD8A to C1QA) was predictive for survival in independent RNAseq data sets from these six cancer types. Finally, the CD8A/C1QA mRNA ratio was also predictive for the response to checkpoint inhibitor therapy.Interpretation: Our findings extend current concepts to procure prognostic information from the tumour immune microenvironment and provide an immune activation signature with high clinical potential in common human cancer types.
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| 70. |
- Mezheyeuski, Artur, et al.
(author)
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The ratio of CD8+ lymphocytes to CD68+CD163+ macrophages is prognostic in immunogenic tumors and predicts immunotherapy response
-
Other publication (other academic/artistic)abstract
- Immune cells in the microenvironment shape tumor development and progression. Through in situ analyses we assessed 15 immune cell classes in 352 colorectal cancers and identified a simpleprognostic signature based on the ratio of anti-tumoral CD8+ lymphocytes to tumor-supportiveCD68+CD163+ macrophages in the tumor microenvironment. The prognostic ability of this signature was superior to the state-of-art immune score and was also demonstrated in four other tumor types. Single-cell analyses identified these CD68+CD163+ macrophages as the source of complement C1q, and the ratio of CD8A to C1QA gene expression levels in bulk RNA predicted survival in five tumor types. In single cell analyses, RNA-based versions of the signature also predicted response to checkpoint inhibitor therapy. This supports broad clinical applicability of immune scores considering CD68+CD163+ macrophages as prognostic and predictive biomarkers in common cancers.
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