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Träfflista för sökning "WFRF:(Feenstra B) "

Sökning: WFRF:(Feenstra B)

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Numrering	Referens	Omslagsbild	Hitta
21.	Alves, AC, et al. (författare) GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI 2019 Ingår i: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 5:9, s. eaaw3095- Tidskriftsartikel (refereegranskat)abstract Longitudinal data find a new variant controlling BMI in infancy and reveal genetic differences between infant and adult BMI.
22.	Feenstra, B, et al. (författare) Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis 2013 Ingår i: JAMA. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 310:7, s. 714-721 Tidskriftsartikel (refereegranskat)
23.	Paternoster, L, et al. (författare) Meta-analysis of genome-wide association studies on atopic dermatitis identifies three novel risk loci 2012 Ingår i: EXPERIMENTAL DERMATOLOGY. - 0906-6705. ; 21:3, s. e3-e3 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
24.	Perry, JRB, et al. (författare) Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche 2014 Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 514:7520, s. 92- Tidskriftsartikel (refereegranskat)
25.	Van Dijck, A, et al. (författare) Clinical Presentation of a Complex Neurodevelopmental Disorder Caused by Mutations in ADNP 2019 Ingår i: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 85:4, s. 287-297 Tidskriftsartikel (refereegranskat)
26.	Zhang, G., et al. (författare) Genetic Associations with Gestational Duration and Spontaneous Preterm Birth 2017 Ingår i: New England Journal of Medicine. - 0028-4793. ; 377:12, s. 1156-1167 Tidskriftsartikel (refereegranskat)abstract BACKGROUND Despite evidence that genetic factors contribute to the duration of gestation and the risk of preterm birth, robust associations with genetic variants have not been identified. We used large data sets that included the gestational duration to determine possible genetic associations. We performed a genomewide association study in a discovery set of samples obtained from 43,568 women of European ancestry using gestational duration as a continuous trait and term or preterm (< 37 weeks) birth as a dichotomous outcome. We used samples from three Nordic data sets (involving a total of 8643 women) to test for replication of genomic loci that had significant genomewide association (P< 5.0x10(-8)) or an association with suggestive significance (P< 1.0x10(-6)) in the discovery set. In the discovery and replication data sets, four loci (EBF1, EEFSEC, AGTR2, and WNT4) were significantly associated with gestational duration. Functional analysis showed that an implicated variant in WNT4 alters the binding of the estrogen receptor. The association between variants in ADCY5 and RAP2C and gestational duration had suggestive significance in the discovery set and significant evidence of association in the replication sets; these variants also showed genomewide significance in a joint analysis. Common variants in EBF1, EEFSEC, and AGTR2 showed association with preterm birth with genomewide significance. An analysis of mother-infant dyads suggested that these variants act at the level of the maternal genome. In this genomewide association study, we found that variants at the EBF1, EEFSEC, AGTR2, WNT4, ADCY5, and RAP2C loci were associated with gestational duration and variants at the EBF1, EEFSEC, and AGTR2 loci with preterm birth. Previously established roles of these genes in uterine development, maternal nutrition, and vascular control support their mechanistic involvement.
27.	Cornelis, MC, et al. (författare) Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption 2015 Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 20:5, s. 647-656 Tidskriftsartikel (refereegranskat)
28.	Dass, Randall A., et al. (författare) Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I 2016 Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 12:8 Tidskriftsartikel (refereegranskat)abstract Ribosome biogenesis is essential for cell growth and proliferation and is commonly elevated in cancer. Accordingly, numerous oncogene and tumor suppressor signaling pathways target rRNA synthesis. In breast cancer, non-canonical Wnt signaling by Wnt5a has been reported to antagonize tumor growth. Here, we show that Wnt5a rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome. Upon DVL1 binding, the Pol I transcription activator and deacetylase Sirtuin 7 (SIRT7) releases from rDNA loci, concomitant with disassembly of Pol I transcription machinery at the rDNA promoter. These findings reveal that Wnt5a signals through DVL1 to suppress rRNA transcription. This provides a novel mechanism for how Wnt5a exerts tumor suppressive effects and why disruption of Wnt5a signaling enhances mammary tumor growth in vivo.
29.	Dass, R, et al. (författare) Wnt5a signals through DVL1 to repress ribosomal DNA transcription by RNA polymerase I 2017 Ingår i: CANCER RESEARCH. - 0008-5472. ; 77 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
30.	Demenais, F, et al. (författare) Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks 2018 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 50:1, s. 42- Tidskriftsartikel (refereegranskat)

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Resultat 21-30 av 38

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Typ av publikation: tidskriftsartikel (33); konferensbidrag (4)

Typ av innehåll: refereegranskat (33); övrigt vetenskapligt/konstnärligt (4)

Författare/redaktör: Feenstra, B (24); Geller, F (18); Melbye, M (16); Uitterlinden, AG (11); Boomsma, DI (10); Teumer, A (10); visa fler...; Hofman, A (10); Rivadeneira, F (10); Esko, T (10); Metspalu, A (10); Gieger, C (10); Hottenga, JJ (9); Melbye, Mads (9); Martin, NG (9); Standl, M (9); Kutalik, Z. (9); Stefansson, K (9); Alves, AC (9); Bisgaard, H (8); van Duijn, CM (8); Ferrucci, L (8); Gudnason, V (8); Ohlsson, Claes, 1965 (8); Vollenweider, P. (8); Lehtimaki, T. (8); Snieder, H. (8); Linneberg, A. (8); Thorleifsson, G (8); Eriksson, JG (8); Wareham, NJ (8); Salomaa, V (8); Thorsteinsdottir, U (8); Willemsen, G (7); Peters, A (7); Heinrich, J. (7); Mahajan, A. (7); Langenberg, C. (7); Bonnelykke, K (7); Loos, RJF (7); Lind, Lars (7); Montgomery, GW (7); Nolte, IM (7); Boerwinkle, E (7); Waldenberger, M. (7); Grarup, N. (7); Laakso, M. (7); McCarthy, MI (7); Beilby, J (7); Boehnke, M (7); Hakonarson, H (7); visa färre...

Lärosäte: Karolinska Institutet (31); Göteborgs universitet (15); Uppsala universitet (15); Lunds universitet (15); Umeå universitet (7); Stockholms universitet (2); visa fler...; Handelshögskolan i Stockholm (2); Mittuniversitetet (2); Högskolan Dalarna (2); Kungliga Tekniska Högskolan (1); Örebro universitet (1); visa färre...

Språk: Engelska (38)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (26); Naturvetenskap (7)

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