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| 14. |
- Dalton, April S., et al.
(författare)
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The marine δ18O record overestimates continental ice volume during Marine Isotope Stage 3
- 2022
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Ingår i: Global and Planetary Change. - Amsterdam : Elsevier. - 0921-8181 .- 1872-6364. ; 212, s. 103814-103814
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Tidskriftsartikel (refereegranskat)abstract
- There is disagreement in the Quaternary research community in how much of the marine δ18O signal is driven by change in ice volume. Here, we examine this topic by bringing together empirical and modelling work for Marine Isotope Stage 3 (MIS 3; 57 ka to 29 ka), a time when the marine δ18O record indicates moderate continental glaciation and a global mean sea level between −60 m and −90 m. We compile and interpret geological data dating to MIS 3 to constrain the extent of major Northern Hemisphere ice sheets (Eurasian, Laurentide, Cordilleran). Many key data, especially published in the past ~15 years, argue for an ice-free core of the formerly glaciated regions that is inconsistent with inferences from the marine δ18O record. We compile results from prior studies of glacial isostatic adjustment to show the volume of ice inferred from the marine δ18O record is unable to fit within the plausible footprint of Northern Hemisphere ice sheets during MIS 3. Instead, a global mean sea level between −30 m and − 50 m is inferred from geological constraints and glacial isostatic modelling. Furthermore, limited North American ice volumes during MIS 3 are consistent with most sea-level bounds through that interval. We can find no concrete evidence of large-scale glaciation during MIS 3 that could account for the missing ~30 m of sea-level equivalent during that time, which suggests that changes in the marine δ18O record are driven by other variables, including water temperature. This work urges caution regarding the reliance of the marine δ18O record as a de facto indicator of continental ice when few geological constraints are available, which underpins many Quaternary studies.
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| 15. |
- Holmqvist, Anna Sällfors, et al.
(författare)
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Assessment of Late Mortality Risk after Allogeneic Blood or Marrow Transplantation Performed in Childhood
- 2018
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Ingår i: JAMA Oncology. - : American Medical Association (AMA). - 2374-2437. ; 4:12
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Tidskriftsartikel (refereegranskat)abstract
- Importance: Allogeneic blood or marrow transplantation (BMT) is a curative option for malignant and nonmalignant diseases of childhood. However, little is known about trends in cause-specific late mortality in this population during the past 3 decades. Objectives: To examine cause-specific late mortality among individuals who have lived 2 years or more after allogeneic BMT performed in childhood and whether rates of late mortality have changed over time. Design, Setting, and Participants: A retrospective cohort study was conducted of individuals who lived 2 years or more after undergoing allogeneic BMT performed in childhood between January 1, 1974, and December 31, 2010. The end of follow-up was December 31, 2016. Exposure: Allogeneic BMT performed in childhood. Main Outcomes and Measures: All-cause mortality, relapse-related mortality, and non-relapse-related mortality. Data on vital status and causes of death were collected using medical records, the National Death Index Plus Program, and Accurint databases. Results: Among 1388 individuals (559 females and 829 males) who lived 2 years or more after allogeneic BMT performed in childhood, the median age at transplantation was 14.6 years (range, 0-21 years). In this cohort, there was a total of 295 deaths, yielding an overall survival rate of 79.3% at 20 years after BMT. The leading causes of death were infection and/or chronic graft-vs-host disease (121 of 244 [49.6%]), primary disease (60 of 244 [24.6%]), and subsequent malignant neoplasms (45 of 244 [18.4%]). Overall, the cohort had a 14.4-fold increased risk for death (95% CI, 12.8-16.1) compared with the general population (292 deaths observed; 20.3 deaths expected). Relative mortality remained elevated at 25 years or more after BMT (standardized mortality ratio, 2.9; 95% CI, 2.0-4.1). The absolute excess risk for death from any cause was 12.0 per 1000 person-years (95% CI, 10.5-13.5). The cumulative incidence of non-relapse-related mortality exceeded that of relapse-related mortality throughout follow-up. The 10-year cumulative incidence of late mortality decreased over time (before 1990, 18.9%; 1990-1999, 12.8%; 2000-2010, 10.9%; P =.002); this decrease remained statistically significant after adjusting for demographic and clinical factors (referent group: <1990; 1990-1999: hazard ratio, 0.64; 95% CI, 0.47-0.89; P =.007; 2000-2010: hazard ratio, 0.49; 95% CI, 0.31-0.76; P =.002; P <.001 for trend). Conclusions and Relevance: Late mortality among children undergoing allogeneic BMT has decreased during the past 3 decades. However, these patients remain at an elevated risk of late mortality even 25 years or more after transplantation when compared with the general population, necessitating lifelong follow-up.
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| 16. |
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| 17. |
- Holmqvist, Anna Sällfors, et al.
(författare)
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Late mortality after autologous blood or marrow transplantation in childhood : A Blood or Marrow Transplant Survivor Study-2 report
- 2018
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 131:24, s. 2720-2729
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Tidskriftsartikel (refereegranskat)abstract
- Autologous blood or marrow transplantation (BMT) is a curative option for several types of childhood cancer. However, there is little information regarding the risk of late mortality. We examined all-cause mortality, relapse-related mortality (RRM), and nonrelapse-related mortality (NRM) in 2-year survivors of autologous BMT performed before age 22 between 1980 and 2010 at 1 of 2 US transplant centers. Vital status information was collected using medical records, National Death Index, and Accurint databases. Overall survival was calculated using Kaplan-Meier techniques. Cumulative incidence of mortality used competing risk methods. Standardized mortality ratio (SMR) was calculated using age-, sex-, and calendar-specific mortality rates from Centers for Disease Control and Prevention. Cox regression analysis was used to determine predictors of all-cause late mortality. Among the 345 2-year survivors, 103 deaths were observed, yielding an overall survival of 70.3% 15 years post-BMT. The leading causes of death included primary disease (50.0%), subsequent neoplasm (21.4%), and infection (18.2%). Overall, the cohort was at a 22-fold increased risk of late mortality (SMR, 21.8; 95% CI, 17.9-26.3), compared with the general population. Mortality rates remained elevated among the 10-year survivors (SMR, 20.6; 95% CI, 9.9-37.2) but approached those of the general population ≥15 years post-BMT. The 10-year cumulative incidence of RRM (14.3%) exceeded that of NRM (10.4%). The 10-year cumulative mortality rate declined over time (<1990, 35.1%; 1990-1999, 25.6%; 2000-2010, 21.8%; P 5 .05). In conclusion, childhood autologous BMT recipients have an increased risk of late mortality, compared with the general population. The late mortality rates have declined over the past 3 decades.
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| 18. |
- Hu, Zhensong, et al.
(författare)
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AMUSE-Antlia. I. Nuclear X-Ray Properties of Early-type Galaxies in a Dynamically Young Galaxy Cluster
- 2023
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 956:2
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Tidskriftsartikel (refereegranskat)abstract
- To understand the formation and growth of supermassive black holes (SMBHs) and their coevolution with host galaxies, it is essential to know the impact of environment on the activity of active galactic nuclei (AGNs). We present new Chandra X-ray observations of nuclear emission from member galaxies in the Antlia cluster, the nearest non-cool core and the nearest merging galaxy cluster, residing at D = 35.2 Mpc. Its inner region, centered on two dominant galaxies NGC 3268 and NGC 3258, has been mapped with three deep Chandra ACIS-I pointings. Nuclear X-ray sources are detected in 7/84 (8.3%) early-type galaxies (ETG) and 2/8 (25%) late-type galaxies with a median detection limit of 8 × 1038 erg s−1. All nuclear X-ray sources but one have a corresponding radio continuum source detected by MeerKAT at the L band. Nuclear X-ray sources detected in early-type galaxies are considered the genuine X-ray counterpart of low-luminosity AGN. When restricted to a detection limit of log ( L X / erg s − 1 ) ≥ 38.9 and a stellar mass of 10 ≤ log ( M ⋆ / M ⊙ ) < 11.6 , six of 11 ETGs are found to contain an X-ray AGN in Antlia, exceeding the AGN occupation fraction of 7/39 (18.0%) and 2/12 (16.7%) in the more relaxed, cool core clusters, Virgo and Fornax, respectively, and rivaling that of the AMUSE-Field ETG of 27/49 (55.1%). Furthermore, more than half of the X-ray AGN in Antlia is hosted by its younger subcluster, centered on NGC 3258. We believe that this is because SMBH activity is enhanced in a dynamically young cluster compared to relatively relaxed clusters.
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| 19. |
- Möller, Per, et al.
(författare)
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Severnaya Zemlya, Arctic Russia: a nucleation area for Kara Sea ice sheets during the Middle to Late Quaternary
- 2006
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791. ; 25:21-22, s. 2894-2936
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Tidskriftsartikel (refereegranskat)abstract
- Quaternary glacial stratigraphy and relative sea-level changes reveal at least four expansions of the Kara Sea ice sheet over the Severnaya Zemlya Archipelago at 79 degrees N in the Russian Arctic, as indicated from tills interbedded with marine sediments, exposed in stratigraphic superposition, and from raised-beach sequences that occur at altitudes up to 140 m a.s.l. Chronologic control is provided by AMS C-14, electron-spin resonance, green-stimulated luminescence, and aspartic-acid geochronology. Major glaciations followed by deglaciation and marine inundation occurred during MIS 10-9, MIS 8-7, MIS 6-5e and MIS 5d-3. The MIS 6-5e event, associated with the high marine limit, implies ice-sheet thickness of > 2000m only 200km from the deep Arctic Ocean, consistent with published evidence of ice grounding at similar to 1000m water depth in the central Arctic Ocean. Till fabrics and glacial tectonics record repeated expansions of local ice caps exclusively, suggesting wet-based ice cap advance followed by cold-based regional ice-sheet expansion. Local ice caps over highland sites along the perimeter of the shallow Kara Sea, including the Byrranga Mountains, appear to have repeatedly fostered initiation of a large Kara Sea ice sheet, with exception of the Last Glacial Maximum (MIS 2), when Kara Sea ice did not impact Severnaya Zemlya and barely graced northernmost Taymyr Peninsula.
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| 20. |
- Nagai, H., et al.
(författare)
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The ALMA Discovery of the Rotating Disk and Fast Outflow of Cold Molecular Gas in NGC 1275
- 2019
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 883:2
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Tidskriftsartikel (refereegranskat)abstract
- We present observations using the Atacama Large Millimeter/submillimeter Array of the CO(2-1), HCN(3-2), and HCO+(3-2) lines in the nearby radio galaxy/brightest cluster galaxy (BCG) NGC 1275 with a spatial resolution of similar to 20 pc. In previous observations, the CO(2-1) emission was detected as radial filaments lying in the east west direction on a kiloparsec scale. We resolved the inner filament and found that it cannot be represented by a simple infalling stream on a sub-kiloparsec scale. The observed complex nature of the filament resembles the cold gas structure predicted by numerical simulations of cold chaotic accretion. Within the central 100 pc, we detected a rotational disk of molecular gas whose mass is similar to 10(8) M-circle dot. This is the first evidence of the presence of a massive cold gas disk on this spatial scale for BCGs. A crude estimate suggests that the accretion rate of the cold gas can be higher than that of hot gas. The disk rotation axis is approximately consistent with the radio-jet axis. This probably suggests that the cold gas disk is physically connected to the innermost accretion disk, which is responsible for jet launching. We also detected absorption features in the HCN(3-2) and HCO+(3-2) spectra against the radio continuum emission mostly radiated by a jet of size similar to 1.2 pc. The absorption features are blueshifted from the systemic velocity by similar to 300-600 km s(-1), suggesting the presence of outflowing gas from the active galactic nucleus (AGN). We discuss the relation of the AGN feeding with cold accretion, the origin of blueshifted absorption, and an estimate of the black hole mass using molecular gas dynamics.
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