| 311. |
- Belshe, R, et al.
(author)
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Support for the RV144 HIV vaccine trial
- 2004
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In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5681, s. 177-177
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Journal article (other academic/artistic)
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| 312. |
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| 313. |
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| 314. |
- Buzio, L, et al.
(author)
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Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals
- 2003
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In: Occupational and Environmental Medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 60:10, s. 789-793
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Journal article (peer-reviewed)abstract
- Aims: To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC). Methods: One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of glutathione S-transferase M1-1 (GSTM1) and T1-1 (GSTT1) were investigated by PCR, occupational history was collected by a structured questionnaire. Results: Subjects with GSTM1 present genotype showed higher risks for RCC, compared to GSTM1 null subjects, if exposed to metals (OR 2.73, 95% CI 0.91 to 8.22 v 1.14, 95% CI 0.46 to 2.82) or pesticides (OR 3.46, 95% CI 1.12 to 10.74 v 1.59, 95% CI 0.48 to 5.34). The GSTT1 present genotype also enhanced the risk (about twofold) of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. Conclusions: Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
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| 315. |
- Buzio, L, et al.
(author)
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Occupational risk factors for renal cell cancer. An Italian case-control study
- 2002
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In: Medicina del Lavoro. - 0025-7818. ; 93:4, s. 303-309
-
Journal article (peer-reviewed)abstract
- Aim: To examine possible associations between occupational and environmental risk factors and renal cell cancer (RCC), a tumour with unclear aetiology and increasing incidence. Methods: A questionnaire-based case-control study of 100 histologically verified cases of RCC and 200 controls was conducted at Parma University Hospital. The control group was enrolled from patients attending different outpatient departments and represented the same residential area as the cases. For all exposure variables under study, two levels of duration were defined: "short" and "prolonged" for less than 10 years or more, respectively. Results: The highest risk estimates for RCC were found for "prolonged" exposure to organic solvents with an odds ratio (OR) of 2.2 (95% confidence interval, CI: 1.0-4,8). "Prolonged" exposures to pesticides and copper sulphate were also associated with increased risk, OR 2.0 (95% CI: 0.8-4.7) and OR 2.7 (95% CI: 1.3-5.5), respectively. Conclusions: Our data suggests an association between RCC and exposure to organic solvents, pesticides and copper sulphate. A risk gradient as a function of exposure duration was found for organic solvents (p= 0.044) and copper sulphate (p= 0.036), but not for pesticides.
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| 316. |
- Cescutti, G., et al.
(author)
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MINCE I. Presentation of the project and of the first year sample
- 2022
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 668
-
Journal article (peer-reviewed)abstract
- Context. In recent years, Galactic archaeology has become a particularly vibrant field of astronomy, with its main focus set on the oldest stars of our Galaxy. In most cases, these stars have been identified as the most metal-poor. However, the struggle to find these ancient fossils has produced an important bias in the observations - in particular, the intermediate metal-poor stars (-2.5 < [Fe/H] < -1.5) have been frequently overlooked. The missing information has consequences for the precise study of the chemical enrichment of our Galaxy, in particular for what concerns neutron capture elements and it will be only partially covered by future multi object spectroscopic surveys such as WEAVE and 4MOST.Aims. Measuring at Intermediate Metallicity Neutron Capture Elements (MINCE) is gathering the first high-quality spectra (high signal-to-noise ratio, S/N, and high resolution) for several hundreds of bright and metal-poor stars, mainly located in our Galactic halo.Methods. We compiled our selection mainly on the basis of Gaia data and determined the stellar atmospheres of our sample and the chemical abundances of each star.Results. In this paper, we present the first sample of 59 spectra of 46 stars. We measured the radial velocities and computed the Galactic orbits for all stars. We found that 8 stars belong to the thin disc, 15 to disrupted satellites, and the remaining cannot be associated to the mentioned structures, and we call them halo stars. For 33 of these stars, we provide abundances for the elements up to zinc. We also show the chemical evolution results for eleven chemical elements, based on recent models.Conclusions. Our observational strategy of using multiple telescopes and spectrographs to acquire high S/N and high-resolution spectra for intermediate-metallicity stars has proven to be very efficient, since the present sample was acquired over only about one year of observations. Finally, our target selection strategy, after an initial adjustment, proved satisfactory for our purposes.
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| 317. |
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| 318. |
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| 319. |
- Lemasle, B., et al.
(author)
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Abundance gradients to trace galaxy formationand evolution : the Galactic disk
- 2022
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In: MEMORIE della Società Astronomica Italiana. - : Italian Astronomical Society (SAIt). - 0037-8720 .- 1824-016X. ; 93:4
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Journal article (peer-reviewed)abstract
- Abundance gradients are one of the few observables constraining the chemo-dynamical models of the Milky Way disk. Here, we review recent improvements regarding the determination of chemical abundances of young stellar systems, Cepheids, and RGB stars, that are used to trace abundance gradients, before focusing on the oxygen gradient.
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| 320. |
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