| 11. |
- Lechman, Eric R, et al.
(författare)
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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.
- 2016
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Ingår i: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 29:2, s. 214-228
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Tidskriftsartikel (refereegranskat)abstract
- To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiation, and increase self-renewal of primary LSC in vivo. Compared with prior results showing miR-126 regulation of normal hematopoietic stem cell (HSC) cycling, these functional stem effects are opposite between LSC and HSC. Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Cheung, Mark C. M., et al.
(författare)
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Probing the Physics of the Solar Atmosphere with the Multi-slit Solar Explorer (MUSE). II. Flares and Eruptions
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 926:1
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Tidskriftsartikel (refereegranskat)abstract
- Current state-of-the-art spectrographs cannot resolve the fundamental spatial (subarcseconds) and temporal (less than a few tens of seconds) scales of the coronal dynamics of solar flares and eruptive phenomena. The highest-resolution coronal data to date are based on imaging, which is blind to many of the processes that drive coronal energetics and dynamics. As shown by the Interface Region Imaging Spectrograph for the low solar atmosphere, we need high-resolution spectroscopic measurements with simultaneous imaging to understand the dominant processes. In this paper: (1) we introduce the Multi-slit Solar Explorer (MUSE), a spaceborne observatory to fill this observational gap by providing high-cadence (<20 s), subarcsecond-resolution spectroscopic rasters over an active region size of the solar transition region and corona; (2) using advanced numerical models, we demonstrate the unique diagnostic capabilities of MUSE for exploring solar coronal dynamics and for constraining and discriminating models of solar flares and eruptions; (3) we discuss the key contributions MUSE would make in addressing the science objectives of the Next Generation Solar Physics Mission (NGSPM), and how MUSE, the high-throughput Extreme Ultraviolet Solar Telescope, and the Daniel K Inouye Solar Telescope (and other ground-based observatories) can operate as a distributed implementation of the NGSPM. This is a companion paper to De Pontieu et al., which focuses on investigating coronal heating with MUSE.
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| 16. |
- De Pontieu, Bart, et al.
(författare)
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Probing the Physics of the Solar Atmosphere with the Multi-slit Solar Explorer (MUSE). I. Coronal Heating
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 926:1
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Tidskriftsartikel (refereegranskat)abstract
- The Multi-slit Solar Explorer (MUSE) is a proposed mission composed of a multislit extreme ultraviolet (EUV) spectrograph (in three spectral bands around 171 Å, 284 Å, and 108 Å) and an EUV context imager (in two passbands around 195 Å and 304 Å). MUSE will provide unprecedented spectral and imaging diagnostics of the solar corona at high spatial (≤05) and temporal resolution (down to ∼0.5 s for sit-and-stare observations), thanks to its innovative multislit design. By obtaining spectra in four bright EUV lines (Fe ix 171 Å, Fe xv 284 Å, Fe xix–Fe xxi 108 Å) covering a wide range of transition regions and coronal temperatures along 37 slits simultaneously, MUSE will, for the first time, "freeze" (at a cadence as short as 10 s) with a spectroscopic raster the evolution of the dynamic coronal plasma over a wide range of scales: from the spatial scales on which energy is released (≤05) to the large-scale (∼170'' × 170'') atmospheric response. We use numerical modeling to showcase how MUSE will constrain the properties of the solar atmosphere on spatiotemporal scales (≤05, ≤20 s) and the large field of view on which state-of-the-art models of the physical processes that drive coronal heating, flares, and coronal mass ejections (CMEs) make distinguishing and testable predictions. We describe the synergy between MUSE, the single-slit, high-resolution Solar-C EUVST spectrograph, and ground-based observatories (DKIST and others), and the critical role MUSE plays because of the multiscale nature of the physical processes involved. In this first paper, we focus on coronal heating mechanisms. An accompanying paper focuses on flares and CMEs.
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| 17. |
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| 18. |
- Golub, Koraljka, Professor, 1975-, et al.
(författare)
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Digital Humanities Master Program at Linnaeus University
- 2024
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Ingår i: Presented at DHNB 2024: Digital Humanities in the Nordic and Baltic Countries 8th Conference, Reykjavik, Iceland, May 27-31, 2024.
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Konferensbidrag (refereegranskat)
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| 19. |
- Golub, Koraljka, Professor, 1975-, et al.
(författare)
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Knowledge Organisation for Digital Humanities : An Introduction
- 2021
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Ingår i: Information and Knowledge Organisation in Digital Humanities. - London : Routledge. - 9781003131816 ; , s. 1-22
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Bokkapitel (refereegranskat)abstract
- The chapter introduces the discipline of knowledge organisation (KO) and its relevance to scholars and practitioners in the field of digital humanities (DH). It sets the stage for the volume's 12 contributed chapters, which present case studies at the intersection of the two research areas. The contributions develop themes that highlight the specific opportunities and challenges of bringing these fields together. The themes of the chapters reflect the preeminent research topics of KO for DH: metadata in cultural heritage collections, which includes topics like conceptual models; data aggregation and metadata enrichment. Information management of textual collections, lexical resources and research outputs provide another important focus. Interfaces to cultural heritage collections and automated techniques are also addressed. Several chapters are directly driven by humanities research questions: one example is the ResearchSpace project, which demonstrates the ineffectiveness of data-based information organisation for historians. Another is the use of geographic information systems (GIS) and semantic annotation to explore a classical text. Finally, the chapter calls for transdisciplinary research collaborations that will bridge the gap within and at the intersections of KO and DH.
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| 20. |
- Golub, M.V., et al.
(författare)
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Effective spring boundary conditions for a damaged interface between dissimilar media in three-dimensional case
- 2016
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Ingår i: International Journal of Solids and Structures. - : Elsevier BV. - 0020-7683. ; 81, s. 141-150
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Tidskriftsartikel (refereegranskat)abstract
- Elastic waves in the presence of a damaged interface between two dissimilar elastic media is investigated in the three-dimensional case. The damaged is modeled as a stochastic distribution of equally sized circular cracks which is transformed into a spring boundary condition. First the scattering by a single circular interface crack between two dissimilar half-spaces is investigated and solved explicitly for normally incident waves in the low frequency limit. The transmission by a distribution of cracks is then determined and is transformed into a spring boundary condition, where effective spring stiffnesses are expressed in terms of elastic moduli and damage parameters. A comparison with previous results for a periodic distribution of cracks shows good agreement.
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