| 551. |
- Godtman, Rebecka Arnsrud, 1981, et al.
(author)
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Intervention-related Deaths in the European Randomized Study of Screening for Prostate Cancer
- 2021
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In: European Urology Open Science. - : Elsevier BV. - 2666-1691 .- 2666-1683. ; 34, s. 27-32
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Journal article (peer-reviewed)abstract
- Background: Identification of intervention-related deaths is important for an accurate assessment of the ratio of benefit to harm in screening trials. Objective: To investigate intervention-related deaths by study arm in the European Randomized Study of Prostate Cancer Screening (ERSPC). Design, setting, and participants: ERSPC is a multicenter trial initiated in the 1990s to investigate whether screening on the basis of prostate-specific antigen (PSA) can decrease prostate cancer mortality. The present study included men in the core age group (55-69 yr: screening group n = 112 553, control group n = 128 681) with 16-yr follow-up. Outcome measurements and statistical analysis: Causes of death among men with prostate cancer in ERSPC were predominantly evaluated by independent national committees via review of medical records according to a predefined algorithm. Intervention-related deaths were defined as deaths caused by complications during the screening procedure, treatment, or follow-up. Descriptive statistics were used for the results. Results and limitations: In total, 34 deaths were determined to be intervention-related, of which 21 were in the screening arm and 13 in the control arm. The overall risk of intervention-related death was 1.41 (95% confidence interval 0.99-1.99) per 10 000 randomized men for both arms combined and varied among centers from 0 to 7.0 per 10 000 randomized men. A limitation of this study is that differences in procedures among centers decreased the comparability of the results. Conclusions: Intervention-related deaths were rare in ERSPC. Monitoring of intervention-related deaths in screening trials is important for assessment of harms. Patient summary: We investigated deaths due to screening or treatment to assess harm in a trial of prostate cancer screening. Few such deaths were identified. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY-NC-ND license (http://creative- commons.org/licenses/by-nc-nd/4.0/).
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| 552. |
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| 553. |
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| 554. |
- Gorini, G, et al.
(author)
-
Triton burnup studies at JET
- 2003
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In: Europhysics Conference Abstracts Vol. 27A (2003).
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Conference paper (other academic/artistic)
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| 555. |
- Hellesen, Carl, et al.
(author)
-
Fast-ion distributions from third harmonic ICRF heating studied with neutron emission spectroscopy
- 2013
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In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 53:11, s. 113009-
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Journal article (peer-reviewed)abstract
- The fast-ion distribution from third harmonic ion cyclotron resonance frequency (ICRF) heating on the Joint European Torus is studied using neutron emission spectroscopy with the time-of-flight spectrometer TOFOR. The energy dependence of the fast deuteron distribution function is inferred from the measured spectrum of neutrons born in DD fusion reactions, and the inferred distribution is compared with theoretical models for ICRF heating. Good agreements between modelling and measurements are seen with clear features in the fast-ion distribution function, that are due to the finite Larmor radius of the resonating ions, replicated. Strong synergetic effects between ICRF and neutral beam injection heating were also seen. The total energy content of the fast-ion population derived from TOFOR data was in good agreement with magnetic measurements for values below 350 kJ.
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| 556. |
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| 557. |
- Hellesen, Carl, 1980-, et al.
(author)
-
Measurements of fast ions and their interactions with MHD activity using neutron emission spectroscopy
- 2010
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In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 50:8, s. 084006-
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Journal article (peer-reviewed)abstract
- Ion cyclotron radio frequency (ICRF) heating can produce fast ion populations with energies reaching up to several megaelectronvolts. Here, we present unique measurements of fast ion distributions from an experiment with 3rd harmonic ICRF heating on deuterium beams using neutron emission spectroscopy (NES). From the experiment, very high DD neutron rates were observed, using only modest external heating powers. This was attributed to acceleration of deuterium beam ions to energies up to about 2-3 MeV, where the DD reactivity is on a par with that of the DT reaction. The high neutron rates allowed for observations of changes in the fast deuterium energy distribution on a time scale of 50 ms. Clear correlations were seen between fast deuterium ions in different energy ranges and magnetohydrodynamic activities, such as monster sawteeth and toroidal Alfven eigen modes (TAE). Specifically, NES data showed that the number of deuterons in the region between 1 and 1.5 MeV were decaying significantly during strong TAE activity, while ions with lower energies around 500 keV were not affected. This was attributed to resonances with the TAE modes.
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| 558. |
- Hellesen, Carl, 1980-, et al.
(author)
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Neutron emission generated by fast deuterons accelerated with ion cyclotron heating at JET
- 2010
-
In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 50:2
-
Journal article (peer-reviewed)abstract
- For the first time, the neutron emission from JET plasmas heated with combined deuterium neutral beam injection and third harmonic ion cyclotron radio frequency heating have been studied with neutron emission spectroscopy (NES). Very high DD neutron rates were observed with only modest external heating powers, which was attributed to acceleration of deuterium beam ions to energies of about 2-3 MeV, where the DD reactivity is on a par of that of the DT reaction. Fast deuterium energy distributions were derived from analysis of NES data and confirm acceleration of deuterium beam ions up to energies around 3 MeV, in agreement with theoretical predictions. The high neutron rates allowed for observations of changes in the fast deuterium populations on a time scale of 50 ms. Correlations were seen between fast deuterium ions at different energies and magnetohydrodynamic activities, such as monster sawtooth crashes and toroidal Alfven eigenmodes.
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| 559. |
- Henriksson, H, et al.
(author)
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Neutron emission study of DT plasmas heated with tritium neutral beams
- 2001
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In: REVIEW OF SCIENTIFIC INSTRUMENTS. - : AMER INST PHYSICS. - 0034-6748. ; 72:1, s. 832-835
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Journal article (peer-reviewed)abstract
- The neutron emission energy spectrum from deuterium-tritium fusion reactions has been measured in experiments carried out at the Joint European Torus for plasmas heated with high power neutral beam (NB) injection of tritium beams at E-b approximate to 150
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| 560. |
- Hjalmarsson, A, et al.
(author)
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Neutron time-of-flight spectrometer for high rate diagnosis of deuterium plasmas
- 2001
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In: REVIEW OF SCIENTIFIC INSTRUMENTS. - : AMER INST PHYSICS. - 0034-6748. ; 72:1, s. 841-844
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Journal article (peer-reviewed)abstract
- The new concept for the design of a neutron time of flight spectrometer operating at high rates of events has been studied based on instrumental modeling and neutron transport calculations. The aim is to find an optimized design for an instrument that can
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