| 51. |
- Abolhassani, H, et al.
(författare)
-
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency
- 2017
-
Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 214:1, s. 91-106
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, we describe four patients from two unrelated families of different ethnicities with a primary immunodeficiency, predominantly manifesting as susceptibility to Epstein-Barr virus (EBV)–related diseases. Three patients presented with EBV-associated Hodgkin’s lymphoma and hypogammaglobulinemia; one also had severe varicella infection. The fourth had viral encephalitis during infancy. Homozygous frameshift or in-frame deletions in CD70 in these patients abolished either CD70 surface expression or binding to its cognate receptor CD27. Blood lymphocyte numbers were normal, but the proportions of memory B cells and EBV-specific effector memory CD8+ T cells were reduced. Furthermore, although T cell proliferation was normal, in vitro–generated EBV-specific cytotoxic T cell activity was reduced because of CD70 deficiency. This reflected impaired activation by, rather than effects during killing of, EBV-transformed B cells. Notably, expression of 2B4 and NKG2D, receptors implicated in controlling EBV infection, on memory CD8+ T cells from CD70-deficient individuals was reduced, consistent with their impaired killing of EBV-infected cells. Thus, autosomal recessive CD70 deficiency is a novel cause of combined immunodeficiency and EBV-associated diseases, reminiscent of inherited CD27 deficiency. Overall, human CD70–CD27 interactions therefore play a nonredundant role in T and B cell–mediated immunity, especially for protection against EBV and humoral immunity.
|
|
| 52. |
|
|
| 53. |
|
|
| 54. |
|
|
| 55. |
- Barigelletti, F, et al.
(författare)
-
A functionalized ruthenium(II)-bis-terpyridine complex as a rod-like luminescent sensor of zinc(II)
- 1998
-
Ingår i: CHEMICAL COMMUNICATIONS. - : ROYAL SOC CHEMISTRY. - 1359-7345. ; :21, s. 2333-2334
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The nearly non-luminescent ruthenium(II)-terpyridine chromophore, functionalized with an uncoordinated terpyridine fragment, 2, undergoes Zn(II)-induced association leading to a luminescent rod-like 2 : Zn2+: 2 species with a luminescence enhancement fact
|
|
| 56. |
- Barreto, VM, et al.
(författare)
-
AID from bony fish catalyzes class switch recombination
- 2005
-
Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 202:6, s. 733-738
-
Tidskriftsartikel (refereegranskat)abstract
- Class switch recombination was the last of the lymphocyte-specific DNA modification reactions to appear in the evolution of the adaptive immune system. It is absent in cartilaginous and bony fish, and it is common to all tetrapods. Class switching is initiated by activation-induced cytidine deaminase (AID), an enzyme expressed in cartilaginous and bony fish that is also required for somatic hypermutation. Fish AID differs from orthologs found in tetrapods in several respects, including its catalytic domain and carboxy-terminal region, both of which are essential for the switching reaction. To determine whether evolution of class switch recombination required alterations in AID, we assayed AID from Japanese puffer and zebra fish for class-switching activity in mouse B cells. We find that fish AID catalyzes class switch recombination in mammalian B cells. Thus, AID had the potential to catalyze this reaction before the teleost and tetrapod lineages diverged, suggesting that the later appearance of a class-switching reaction was dependent on the evolution of switch regions and multiple constant regions in the IgH locus.
|
|
| 57. |
|
|
| 58. |
|
|
| 59. |
|
|
| 60. |
- Bogstedt, AK, et al.
(författare)
-
Passive immunity against diarrhoea
- 1996
-
Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 0803-5253 .- 1651-2227. ; 85:2, s. 125-128
-
Tidskriftsartikel (refereegranskat)
|
|
