| 11. |
- Hannon, Stephen, et al.
(författare)
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H α morphologies of star clusters : a LEGUS study of H II region evolution time-scales and stochasticity in low-mass clusters
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 490:4, s. 4648-4665
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Tidskriftsartikel (refereegranskat)abstract
- The morphology of H II regions around young star clusters provides insight into the time-scales and physical processes that clear a cluster's natal gas. We study similar to 700 young clusters (<= 10 Myr) in three nearby spiral galaxies (NGC 7793, NGC 4395, and NGC 1313) using Hubble Space Telescope (HST) imaging from LEGUS (Legacy ExtraGalactic Ultraviolet Survey). Clusters are classified by their H alpha morphology (concentrated, partially exposed, no-emission) and whether they have neighbouring clusters (which could affect the clearing time-scales). Through visual inspection of the HST images, and analysis of ages, reddenings, and stellar masses from spectral energy distributions fitting, together with the (U - B), (V - I) colours, we find (1) the median ages indicate a progression from concentrated (similar to 3Myr), to partially exposed (similar to 4Myr), to no H alpha emission (>5Myr), consistent with the expected temporal evolution of H II regions and previous results. However, (2) similarities in the age distributions for clusters with concentrated and partially exposed H alpha morphologies imply a short time-scale for gas clearing (less than or similar to 1 Myr). Also, (3) our cluster sample's median mass is similar to 1000 M-circle dot, and a significant fraction (similar to 20 per cent) contain one or more bright red sources (presumably supergiants), which can mimic reddening effects. Finally, (4) the median E(B - V) values for clusters with concentrated H alpha and those without H alpha emission appear to be more similar than expected (similar to 0.18 versus similar to 0.14, respectively), but when accounting for stochastic effects, clusters without H alpha emission are less reddened. To mitigate stochastic effects, we experiment with synthesizing more massive clusters by stacking fluxes of clusters within each H alpha morphological class. Composite isolated clusters also reveal a colour and age progression for H alpha morphological classes, consistent with analysis of the individual clusters.
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| 12. |
- Hop, Paul J., et al.
(författare)
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Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
- 2022
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science. - 1946-6234 .- 1946-6242. ; 14:633
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Tidskriftsartikel (refereegranskat)abstract
- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) exposures and disease progression, as well as providing a potential mechanism that mediates genetic or environmental risk. Here, we present a blood-based epigenome-wide association study meta-analysis in 9706 samples passing stringent quality control (6763 patients, 2943 controls). We identified a total of 45 differentially methylated positions (DMPs) annotated to 42 genes, which are enriched for pathways and traits related to metabolism, cholesterol biosynthesis, and immunity. We then tested 39 DNA methylation-based proxies of putative ALS risk factors and found that high-density lipoprotein cholesterol, body mass index, white blood cell proportions, and alcohol intake were independently associated with ALS. Integration of these results with our latest genome-wide association study showed that cholesterol biosynthesis was potentially causally related to ALS. Last, DNA methylation at several DMPs and blood cell proportion estimates derived from DNA methylation data were associated with survival rate in patients, suggesting that they might represent indicators of underlying disease processes potentially amenable to therapeutic interventions.
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| 13. |
- Albert, F. W., et al.
(författare)
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Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection
- 2011
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Ingår i: Heredity. - : Springer Science and Business Media LLC. - 0018-067X .- 1365-2540. ; 107:3, s. 205-214
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Tidskriftsartikel (refereegranskat)abstract
- The identification of the causative genetic variants in quantitative trait loci (QTL) influencing phenotypic traits is challenging, especially in crosses between outbred strains. We have previously identified several QTL influencing tameness and aggression in a cross between two lines of wild-derived, outbred rats (Rattus norvegicus) selected for their behavior towards humans. Here, we use targeted sequence capture and massively parallel sequencing of all genes in the strongest QTL in the founder animals of the cross. We identify many novel sequence variants, several of which are potentially functionally relevant. The QTL contains several regions where either the tame or the aggressive founders contain no sequence variation, and two regions where alternative haplotypes are fixed between the founders. A re-analysis of the QTL signal showed that the causative site is likely to be fixed among the tame founder animals, but that several causative alleles may segregate among the aggressive founder animals. Using a formal test for the detection of positive selection, we find 10 putative positively selected regions, some of which are close to genes known to influence behavior. Together, these results show that the QTL is probably not caused by a single selected site, but may instead represent the joint effects of several sites that were targets of polygenic selection.
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| 14. |
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| 15. |
- Halme, P., et al.
(författare)
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Challenges of ecological restoration : Lessons from forests in northern Europe
- 2013
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Ingår i: Biological Conservation. - : Elsevier BV. - 0006-3207 .- 1873-2917. ; 167, s. 248-256
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Forskningsöversikt (refereegranskat)abstract
- The alarming rate of ecosystem degradation has raised the need for ecological restoration throughout different biomes and continents. North European forests may appear as one of the least vulnerable ecosystems from a global perspective, since forest cover is not rapidly decreasing and many ecosystem services remain at high level. However, extensive areas of northern forests are heavily exploited and have lost a major part of their biodiversity value. There is a strong requirement to restore these areas towards a more natural condition in order to meet the targets of the Convention on Biological Diversity. Several northern countries are now taking up this challenge by restoring forest biodiversity with increasing intensity. The ecology and biodiversity of boreal forests are relatively well understood making them a good model for restoration activities in many other forest ecosystems. Here we introduce northern forests as an ecosystem, discuss the historical and recent human impact and provide a brief status report on the ecological restoration projects and research already conducted there. Based on this discussion, we argue that before any restoration actions commence, the ecology of the target ecosystem should be established with the need for restoration carefully assessed and the outcome properly monitored. Finally, we identify the most important challenges that need to be solved in order to carry out efficient restoration with powerful and long-term positive impacts on biodiversity: coping with unpredictability, maintaining connectivity in time and space, assessment of functionality, management of conflicting interests and social restrictions and ensuring adequate funding. © 2013 Elsevier Ltd.
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| 16. |
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| 17. |
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| 18. |
- Hannon, G E, et al.
(författare)
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Climate change and human settlement as drivers of late-Holocene vegetational change in the Faroe Islands
- 2005
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Ingår i: The Holocene. - : SAGE Publications. - 0959-6836 .- 1477-0911. ; 15:5, s. 639-647
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Tidskriftsartikel (refereegranskat)abstract
- Changes in Faroese land surfaces during the late Holocene reflect intimate interactions between cultural and environmental development. Analyses of fossil wood, pollen and plant macrofossils indicate that the present open landscape replaced shrubby vegetation that was present from c. 6000 BC Up to c. AD 660. Conditions altered during the late Holocene, with loss of woody vegetation and increasing erosion: trends that were initiated prior to human settlement. AMS dating of sub-fossil Betula, Salix and Juniperus found buried in peat profiles from the islands of Suouroy, Sandoy, Eysturoy, Vagar and Streymoy, revealed that the islands had at least partial woody vegetation cover up to the time of continuous settlement. The settlement horizon, identified in a lacustrine sequence on the island of Eysturoy, dated to c. AD 570. It comprised pollen evidence for the cultivation of Hordeum, cultural macrofossil assemblages, charcoal fragments, diatom assemblage changes indicating lake nutrient enrichment and physical measurements showing increased sedimentation rates. The pollen record showed that heathland development was initiated prior to anthropogenic impact. The ecosystem impacts of settlement were therefore superimposed on landscape changes that began around AD 250. The earlier changes were most likely forced by increased storminess and declining atmospheric temperatures.
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| 19. |
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| 20. |
- Wofford, Aida, et al.
(författare)
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Candidate LBV stars in galaxy NGC 7793 found via HST photometry plus MUSE spectroscopy
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 493:2, s. 2410-2428
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Tidskriftsartikel (refereegranskat)abstract
- Only about 19 Galactic and 25 extragalactic bonafide luminous blue variables (LBVs) are known to date. This incomplete census prevents our understanding of this crucial phase of massive star evolution which leads to the formation of heavy binary black holes via the classical channel. With large samples of LBVs one could better determine the duration and maximum stellar luminosity which characterize this phase. We search for candidate LBVs (cLBVs) in a new galaxy, NGC 7793. For this purpose, we combine high spatial resolution images from two Hubble Space Telescope (HST) programs with optical spectroscopy from the Multi Unit Spectroscopic Explorer (MUSE). By combining PSF-fitting photometry measured on F547M, F657N, and F814W images, with restrictions on point-like appearance (at HST resolution) and Ha luminosity, we find 100 potential cLBVs, 36 of which fall in the MUSE fields. Five of the latter 36 sources are promising cLBVs which have M-V <= -7 and a combination of: H alpha with a P-Cygni profile; no [O I]lambda 6300 emission; weak or no [O III]lambda 5007 emission; large [N II]/H alpha relative to HII regions; and [S II]lambda 6716/[S II]lambda 6731 similar to 1. It is not clear if these five cLBVs are isolated from O-type stars, which would favour the binary formation scenario of LBVs. Our study, which approximately covers one fourth of the optical disc of NGC 7793, demonstrates how by combining the above HST surveys with multi-object spectroscopy from 8-m class telescopes, one can efficiently find large samples of cLBVs in nearby galaxies.
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