| 121. |
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| 122. |
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| 123. |
- Trischler, Jakob, et al.
(författare)
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Exploring the ‘black box’ of customer co-creation processes
- 2017
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Ingår i: Journal of Services Marketing. - Bingley, UK : Emerald Group Publishing Limited. - 0887-6045. ; 31:3, s. 265-280
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - Many firms use customer co-creation practices with the aim of benefiting from their customers' knowledge, skills and resources. This paper aims to explore co-creation processes which involve users with different background characteristics and motivational drivers.Design/methodology/approach -The study builds on an analysis of data from six teams in which users collaborated with in-house professionals for the development of new service concepts. Observations and open-ended questionnaires provided insights into the teams' development processes. Independent experts rated the generated concepts. The data were analysed using cross-comparison matrices.FindingsThe findings suggest that the co-creation process and outcomes can be influenced by numerous intra-team factors, including relationship and task conflicts, participation style, team bonding, team identity and cohesiveness and intra-team collaboration. Their occurrence and influence seem to be linked with a specific team composition. A conceptual co-creation process model and six propositions are used to describe the complex relationships between team composition, intra-team factors and key innovation outcomes.Research limitations/implications - Research that investigates user involvement in teams needs to consider the complexity of intra-team factors affecting the development process and outcomes. The findings are limited to a specific setting, design task and user sample. Future research should replicate this study in different sectors.Practical implications - Key to customer co-creation is the systematic recruitment of users based on their background characteristics and motivational drivers. For instance, the involvement of users with very specific innovation-related benefit expectations can cause conflict, leading to narrowly focused outcomes. This, however, can be mitigated by the form of facilitation and roles adopted by in-house professionals. Understanding intra-team dynamics can allow the firm to assemble and facilitate customer co-creation so that generated outcomes can align with set innovation targets.Originality/value -This paper provides original insights into the "black box" of the customer co-creation process and the complex relationship between team composition, intra-team factors and key innovation outcomes.
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| 124. |
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| 125. |
- Trolle Lagerros, Ylva, et al.
(författare)
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Risk of Delayed Discharge and Reoperation of Gastric Bypass Patients with Psychiatric Comorbidity : a Nationwide Cohort Study
- 2020
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Ingår i: Obesity Surgery. - : Springer Science and Business Media LLC. - 0960-8923 .- 1708-0428. ; 30:7, s. 2511-2518
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundGastric bypass (GBP) surgery is considered a safe and effective treatment for obesity. However, there is uncertainty regarding the impact of preexisting psychiatric comorbidity on GBP complications. We have investigated whether a psychiatric diagnosis before GBP surgery is associated with delayed discharge (the odds of being in the 90th percentile of length of stay) and rate of reoperation in a nationwide Swedish cohort.MethodsPatients undergoing GBP surgery during 2008–2012 were identified and followed up through the National Patient Register and the Prescribed Drug Register. Logistic regression models were fitted to the studied outcomes.ResultsAmong the 22,539 patients identified, a prior diagnosis of bipolar disorder, schizophrenia, depression, neurotic disorders, ADHD (attention deficit hyperactivity disorder), substance use disorder, eating disorder, personality disorder, or self-harm since 1997 (n = 9480) was found to be associated with delayed discharge after GBP surgery (odds ratio [OR] = 1.47, confidence interval [CI] 1.34–1.62), especially in patients with psychiatric hospitalization exceeding 1 week in the 2 years preceding GBP surgery (OR = 2.06, CI 1.30–3.28), compared with those not hospitalized within psychiatry. Likewise, patients with a prior psychiatric diagnosis were more likely to be reoperated within 30 days (OR = 1.25, CI 1.11–1.41), with twice the likelihood OR 2.23 (CI 1.26–3.92) for patients with psychiatric hospitalization of up to a week in the 2 years preceding GBP surgery, compared with patients who had not been hospitalized within psychiatry.ConclusionsA psychiatric diagnosis before GBP surgery was associated with delayed discharge and increased likelihood of reoperation within 30 days. Patients with a prior psychiatric diagnosis may, therefore, need additional attention and support.
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| 126. |
- Ulenius, Jakob, 1983-
(författare)
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Maskulinitetens mening : En fenomenologisk undersökning av den psykoterapeutiska situationen
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Masculinity is an elusive and ambiguous phenomenon that can manifest itself in many different ways in different contexts. This study focuses on the emergence of masculinity within the psychodynamic psychotherapeutic situation, with a focus on how masculinity is experienced. Both patient and therapist carry notions and experiences of masculinity into the therapy room. In addition, the psychotherapeutic situation, in itself, can evoke notions of gender. Sometimes masculinity can be the focus of the therapy, which previous research to some extent has drawn theoretical attention to, with a focus on certain aspects. However, there is a need for an empirical holistic approach to how masculinity is manifested in psychotherapy.The purpose of the dissertation is to clarify the meaning of masculinity, as it appears in the psychotherapeutic situation. This purpose is answered by empirically describing how masculinity is experienced in psychotherapy from two perspectives – the patient's and the psychotherapist's. The study is based on 27 in-depth interviews which were analyzed using a phenomenological method. The result is presented in the form of two meaning structures; one for the patient's experience of masculinity and another for the psychotherapist's experience. Finally, these two meaning structures are compared, in order to highlight common features and differences.The study shows that the patient's experience of masculinity is primarily rooted in the patient’s lived, first-person perspective, while the therapist's experience to a greater extent is constituted by a second- and third-person perspective. Both patient and therapist symbolize and conceptualize masculinity through different levels, where they share a bodily and a ”taken-for-granted” dimension. Their conceptualizations differ in that the therapist also has access to a theoretically informed perspective. Both patient and therapist constitute masculinity in a normative way; for the patient, the normative dimension is perceived in terms of ego-syntonic and ego-dystonic masculinity ideals and norms, while the therapist defines masculinity as either a positive or a negative phenomenon.A distinctive aspect of the result is, that masculinity can appear in terms of suffering for the patient or in terms of masculinity issues for the therapist. The masculinity suffering/masculinity issues can be associated with a polarized or immature form of masculinity, which – in the context of therapy – can undergo changes until appearing in a non-polarized, mature way. Another type of masculinity suffering, is when the patient does not feel in contact with masculinity. The result describes a changed masculinity experience in terms of a changed masculinity narrative, which can undergo three different elements; the prefigurative ground, the configurative processing, and the refigurative gestalt of masculinity. The study also sheds light on how the patient and therapist relate to one another in the light of a changed masculinity narrative.The comparative analysis shows that masculinity can be attributed with divergent meanings within the psychotherapeutic situation, and also includes a developmental, therapeutic and normative dimension. One conclusion is that masculinity has two sources of meaning; one lived and one theoretical origin. The lived perspective is linked to the life world, while the theoretical perspective has the potential to elaborate and broaden the life world experience of masculinity.
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| 127. |
- van der Schot, Gijs, et al.
(författare)
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Imaging single cells in a beam of live cyanobacteria with an X-ray laser
- 2015
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- There exists a conspicuous gap of knowledge about the organization of life at mesoscopic levels. Ultra-fast coherent diffractive imaging with X-ray free-electron lasers can probe structures at the relevant length scales and may reach sub-nanometer resolution on micron-sized living cells. Here we show that we can introduce a beam of aerosolised cyanobacteria into the focus of the Linac Coherent Light Source and record diffraction patterns from individual living cells at very low noise levels and at high hit ratios. We obtain two-dimensional projection images directly from the diffraction patterns, and present the results as synthetic X-ray Nomarski images calculated from the complex-valued reconstructions. We further demonstrate that it is possible to record diffraction data to nanometer resolution on live cells with X-ray lasers. Extension to sub-nanometer resolution is within reach, although improvements in pulse parameters and X-ray area detectors will be necessary to unlock this potential.
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| 128. |
- van der Schot, Gijs, et al.
(författare)
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Open data set of live cyanobacterial cells imaged using an X-ray laser
- 2016
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Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Structural studies on living cells by conventional methods are limited to low resolution because radiation damage kills cells long before the necessary dose for high resolution can be delivered. X-ray free-electron lasers circumvent this problem by outrunning key damage processes with an ultra-short and extremely bright coherent X-ray pulse. Diffraction-before-destruction experiments provide high-resolution data from cells that are alive when the femtosecond X-ray pulse traverses the sample. This paper presents two data sets from micron-sized cyanobacteria obtained at the Linac Coherent Light Source, containing a total of 199,000 diffraction patterns. Utilizing this type of diffraction data will require the development of new analysis methods and algorithms for studying structure and structural variability in large populations of cells and to create abstract models. Such studies will allow us to understand living cells and populations of cells in new ways. New X-ray lasers, like the European XFEL, will produce billions of pulses per day, and could open new areas in structural sciences.
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| 129. |
- van Velzen, Sjoert, et al.
(författare)
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Establishing accretion flares from supermassive black holes as a source of high-energy neutrinos
- 2024
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Ingår i: Monthly notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 529:3, s. 2559-2576
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Tidskriftsartikel (refereegranskat)abstract
- The origin of cosmic high-energy neutrinos remains largely unexplained. For high-energy neutrino alerts from IceCube, a coincidence with time-variable emission has been seen for three different types of accreting black holes: (1) a gamma-ray flare from a blazar (TXS 0506+056), (2) an optical transient following a stellar tidal disruption event (TDE; AT2019dsg), and (3) an optical outburst from an active galactic nucleus (AGN; AT2019fdr). For the latter two sources, infrared follow-up observations revealed a powerful reverberation signal due to dust heated by the flare. This discovery motivates a systematic study of neutrino emission from all supermassive black hole with similar dust echoes. Because dust reprocessing is agnostic to the origin of the outburst, our work unifies TDEs and high-amplitude flares from AGN into a population that we dub accretion flares. Besides the two known events, we uncover a third flare that is coincident with a PeV-scale neutrino (AT2019aalc). Based solely on the optical and infrared properties, we estimate a significance of 3.6σ for this association of high-energy neutrinos with three accretion flares. Our results imply that at least ∼10 per cent of the IceCube high-energy neutrino alerts could be due to accretion flares. This is surprising because the sum of the fluence of these flares is at least three orders of magnitude lower compared to the total fluence of normal AGN. It thus appears that the efficiency of high-energy neutrino production in accretion flares is increased compared to non-flaring AGN. We speculate that this can be explained by the high Eddington ratio of the flares.
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| 130. |
- Vikingsson, Svante, et al.
(författare)
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LC-QTOF-MS Identification of Major Urinary Cyclopropylfentanyl Metabolites Using Synthesized Standards
- 2019
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Ingår i: Journal of Analytical Toxicology. - : OXFORD UNIV PRESS INC. - 0146-4760 .- 1945-2403. ; 43:8, s. 607-614
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Tidskriftsartikel (refereegranskat)abstract
- Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl along with synthesis routes. In this study, metabolites were identified in 13 post-mortem urine samples using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Samples were analyzed with and without enzymatic hydrolysis, and seven potential metabolites were synthesized in-house to provide the identity of major metabolites. Cyclopropylfentanyl was detected in all samples, and the most abundant metabolite was norcyclopropylfentanyl (M1) that was detected in 12 out of 13 samples. Reference materials were synthesized (synthesis routes provided) to identify the exact structure of the major metabolites 4-hydroxyphenethyl cyclopropylfentanyl (M8), 3,4-dihydroxyphenethyl cyclopropylfentanyl (M5) and 4-hydroxy-3-methoxyphenethyl cyclopropylfentanyl (M9). These metabolites are suitable urinary markers of cyclopropylfentanyl intake as they are unique and detected in a majority of hydrolyzed urine samples. Minor metabolites included two quinone metabolites (M6 and M7), not previously reported for fentanyl analogs. Interestingly, with the exception of norcyclopropylfentanyl (M1), the metabolites appeared to be between 40% and 90% conjugated in urine. In total, 11 metabolites of cyclopropylfentanyl were identified, including most metabolites previously reported after hepatocyte incubation.
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