| 541. |
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| 542. |
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| 543. |
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| 544. |
- Stacey, Simon N, et al.
(författare)
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Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
- 2010
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Ingår i: PLoS genetics. - : Public Library of Science. - 1553-7404. ; 6:7, s. e1001029-
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Tidskriftsartikel (refereegranskat)abstract
- We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls. We found that rs2046210[T] does not confer substantial risk of breast cancer in Europeans and Africans (OR = 1.04, P = 0.099, and OR = 0.98, P = 0.77, respectively). Rather, in those ancestries, an association signal arises from a group of less common SNPs typified by rs9397435. The rs9397435[G] allele was found to confer risk of breast cancer in European (OR = 1.15, P = 1.2 x 10(-3)), African (OR = 1.35, P = 0.014), and Asian (OR = 1.23, P = 2.9 x 10(-4)) population samples. Combined over all ancestries, the OR was 1.19 (P = 3.9 x 10(-7)), was without significant heterogeneity between ancestries (P(het) = 0.36) and the SNP fully accounted for the association signal in each ancestry. Haplotypes bearing rs9397435[G] are well tagged by rs2046210[T] only in Asians. The rs9397435[G] allele showed associations with both estrogen receptor positive and estrogen receptor negative breast cancer. Using early-draft data from the 1,000 Genomes project, we found that the risk allele of a novel SNP (rs77275268), which is closely correlated with rs9397435, disrupts a partially methylated CpG sequence within a known CTCF binding site. These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping.
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| 545. |
- Staudt, Matthias, 1977, et al.
(författare)
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Coupling of an erbium spin ensemble to a superconducting resonator
- 2012
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Ingår i: Journal of Physics B: Atomic, Molecular and Optical Physics. - : IOP Publishing. - 1361-6455 .- 0953-4075. ; 45:12, s. Art. no. 124019-
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Tidskriftsartikel (refereegranskat)abstract
- A quantum coherent interface between optical and microwave photons can be used as a basic building block within a future quantum information network. The interface is envisioned as an ensemble of rare-earth ions coupled to a superconducting resonator, allowing for coherent transfer between optical and microwave photons. Towards this end, we have realized a hybrid device coupling a Er3+-doped Y2SiO5 crystal in a superconducting coplanar waveguide cavity. We observe a collective spin coupling of 4 MHz and a spin linewidth of down to 75 MHz.
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| 546. |
- Stenberg, Georg, et al.
(författare)
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Semantic Priming In Schizophrenia - The N400 In A Picture Verification Task
- 2005
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Ingår i: Society for Psychophysiological Research. - 0048-5772.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Semantic memory access has been characterized as abnormal in schizophrenia, but findings concerning automatic spreading activation at short stimulus onset asynchronies (SOA) have been inconsistent. Using the N400 as an indicator of semantic priming, a recent study (Mathalon, Faustman, & Ford, 2002) found evidence of hyperpriming in schizophrenic patients in a picture verification task. The present study replicates the Mathalon et al. study and extends the paradigm to a third stimulus condition. Pictures of common objects were shown, followed at short SOAs by words with three types of semantic relation to the picture: (a) matching, e.g. dog-dog, (b) related, e.g. dog-cat, or (c) unrelated, e.g. dog-bicycle. We expected patients to show a smaller N400 than controls in the related condition, indicating hyperpriming of semantic relations. Eighteen medicated patients and twenty-four controls participated. Behavioral results revealed slowed reaction times in patients, but no interaction with stimulus condition. The P300 in the matching condition was normal. The N400 in the related condition was, as predicted, reduced in patients. Unexpectedly, the unrelated condition showed the same difference between patients and controls, suggesting that reduced N400 was not caused by activation spreading along normal pathways. Subtraction waveforms (related - unrelated) were equivalent in amplitude between groups, but peak latency was longer in patients. The results indicate slowed processing, and an atypical pattern of semantic activation in schizophrenia.
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| 547. |
- Stough, Roger R., et al.
(författare)
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Endogenous regional growth and development : Clusters, agglomeration and entrepreneurship
- 2014
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Ingår i: Agglomeration, Clusters and Entrepreneurship. - : Edward Elgar Publishing. ; , s. 3-15
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Regional economic development has experienced considerable dynamism over the recent past. Perhaps the most stunning cases are China and India rising to emergent country status by the turn of the millennium, when most development economists believed in the mid to late twentieth century that such developments could not and would never occur. Paralleling these developments are similar stories of rapid growth at both the national (for example, the four little dragons-Hong Kong, Korea, Singapore and Taiwan; and also Malaysia and Brazil) and the sub-national regional level, which are elaborated on below. With time now for hindsight, some of the reasons these development successes are beginning to emerge are becoming known. The four little dragons' success is tied to what has come to be known as export-dominated development. By focusing on sizeable export markets for non-durable and to some extent durable goods at first and then later, on durables coupled with disciplined, educated and educable labor forces, these countries rose to developed status by the closing decade of the twentieth century. While all of this was going on, new thinking about economic growth-such as the 'new growth theory', along with recognition of emerging patterns of change such as agglomeration, clustering and entrepreneurship-began to modify the quasi-static development views of the neo-classical perspective on economic growth that had changed little since the 1950s following the work of Solow.
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| 548. |
- Stough, Roger R., et al.
(författare)
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Endogenous Regional Growth and Development: Clusters, Agglomeration and Entrepreneurship
- 2014
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Ingår i: Agglomeration, Clusters And Entrepreneurship. - : Edward Elgar Publishing. - 978 1 84980 926 9 - 978 1 78347 263 5 ; , s. 3-15
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Regional economic development has experienced considerable dynamism over the recent past. Perhaps the most stunning cases are China and India rising to emergent country status by the turn of the millennium, when most development economists believed in the mid to late twentieth century that such developments could not and would never occur. Paralleling these developments are similar stories of rapid growth at both the national (for example, the four little dragons-Hong Kong, Korea, Singapore and Taiwan; and also Malaysia and Brazil) and the sub-national regional level, which are elaborated on below. With time now for hindsight, some of the reasons these development successes are beginning to emerge are becoming known. The four little dragons' success is tied to what has come to be known as export-dominated development. By focusing on sizeable export markets for non-durable and to some extent durable goods at first and then later, on durables coupled with disciplined, educated and educable labor forces, these countries rose to developed status by the closing decade of the twentieth century. While all of this was going on, new thinking about economic growth-such as the 'new growth theory', along with recognition of emerging patterns of change such as agglomeration, clustering and entrepreneurship-began to modify the quasi-static development views of the neo-classical perspective on economic growth that had changed little since the 1950s following the work of Solow.
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| 549. |
- Strandroth, Johan, 1978, et al.
(författare)
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A New Method to Evaluate Future Impact of Vehicle Safety Technology in Sweden
- 2012
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Ingår i: SAE Technical Papers. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191 .- 2688-3627. ; 56, s. 497-509
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Tidskriftsartikel (refereegranskat)abstract
- In the design of a safe road transport system there is a need to better understand the safety challenges lying ahead. One way of doing that is to evaluate safety technology with retrospective analysis of crashes. However, by using retrospective data there is the risk of adapting safety innovations to scenarios irrelevant in the future. Also, challenges arise as safety interventions do not act alone but are rather interacting components in a complex road transport system. The objective of this study was therefore to facilitate the prioritizing of road safety measures by developing and applying a new method to consider possible impact of future vehicle safety technology. The key point was to project the chain of events leading to a crash today into the crashes for a given time in the future. Assumptions on implementation on safety technologies were made and these assumptions were applied on the crashes of today. It was estimated which crashes would be prevented and the residual was analyzed to identify the characteristics of future crashes. The Swedish Transport Administration's in-depth studies of fatal crashes from 2010 involving car passengers (n=156) were used. This study estimated that the number of killed car occupant would be reduced with 53 percent from the year 2010 to 2020. Through this new method, valuable information regarding the characteristic of the future crashes was found. The results of this study showed that it was possible to evaluate future impact of vehicle safety technology if detailed and representative crash data is available.
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| 550. |
- Svensson, Ida-Maria, 1988, et al.
(författare)
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Microwave photon generation in a doubly tunable superconducting resonator
- 2018
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 969:1
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Konferensbidrag (refereegranskat)abstract
- We have created a doubly tunable resonator, with the intention to simulate relativistic motion of the resonator boundaries in real space. Our device is a superconducting coplanar-waveguide microwave resonator, with fundamental resonant frequency ω 1 / (2 π ) ~ 5 GHz. Both of its ends are terminated to ground via dc-SQUIDs, which serve as magnetic-flux-controlled inductances. Applying a flux to either SQUID allows the tuning of ω 1 / (2 π ) by approximately 700 MHz. Using two separate on-chip magnetic-flux lines, we modulate the SQUIDs with two tones of equal frequency, close to 2 ω 1 . We observe photon generation, at ω 1 , above a certain pump amplitude threshold. By varying the relative phase of the two pumps we are able to control this threshold, in good agreement with a theoretical model. At the same time, some of our observations deviate from the theoretical predictions, which we attribute to parasitic couplings resulting in current driving of the SQUIDs
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