| 41. |
- Buckland, Genevieve, et al.
(författare)
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Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
- 2010
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 91:2, s. 381-390
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. OBJECTIVE: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. DESIGN: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. RESULTS: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). CONCLUSION: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.
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| 42. |
- Callaghan, Terry V., et al.
(författare)
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Changing snow cover and its impacts
- 2011
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Ingår i: Snow, Water, Ice and Permafrost in the Arctic (SWIPA). - Oslo : Arctic Monitoring and Assessment Programme. - 9788279710714 ; , s. 4:1-4:58
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Bokkapitel (refereegranskat)
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| 43. |
- Callaghan, Terry V., et al.
(författare)
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The Changing Face of Arctic Snow Cover: A Synthesis of Observed and Projected Changes
- 2011
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Ingår i: Ambio: a Journal of Human Environment. - : Springer Science and Business Media LLC. - 0044-7447. ; 40, s. 17-31
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Tidskriftsartikel (refereegranskat)abstract
- Analysis of in situ and satellite data shows evidence of different regional snow cover responses to the widespread warming and increasing winter precipitation that has characterized the Arctic climate for the past 40-50 years. The largest and most rapid decreases in snow water equivalent (SWE) and snow cover duration (SCD) are observed over maritime regions of the Arctic with the highest precipitation amounts. There is also evidence of marked differences in the response of snow cover between the North American and Eurasian sectors of the Arctic, with the North American sector exhibiting decreases in snow cover and snow depth over the entire period of available in situ observations from around 1950, while widespread decreases in snow cover are not apparent over Eurasia until after around 1980. However, snow depths are increasing in many regions of Eurasia. Warming and more frequent winter thaws are contributing to changes in snow pack structure with important implications for land use and provision of ecosystem services. Projected changes in snow cover from Global Climate Models for the 2050 period indicate increases in maximum SWE of up to 15% over much of the Arctic, with the largest increases (15-30%) over the Siberian sector. In contrast, SCD is projected to decrease by about 10-20% over much of the Arctic, with the smallest decreases over Siberia (<10%) and the largest decreases over Alaska and northern Scandinavia (30-40%) by 2050. These projected changes will have far-reaching consequences for the climate system, human activities, hydrology, and ecology.
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| 44. |
- Canbäck, Björn, et al.
(författare)
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The Littorina sequence database (LSD) - an online resource for genomic data.
- 2012
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Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 12, s. 142-148
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Tidskriftsartikel (refereegranskat)abstract
- We present an interactive, searchable expressed sequence tag database for the periwinkle snail Littorina saxatilis, an upcoming model species in evolutionary biology. The database is the result of a hybrid assembly between Sanger and 454 sequences, 1290 and 147 491 sequences respectively. Normalized and non-normalized cDNA was obtained from different ecotypes of L. saxatilis collected in the UK and Sweden. The Littorina sequence database (LSD) contains 26 537 different contigs, of which 2453 showed similarity with annotated proteins in UniProt. Querying the LSD permits the selection of the taxonomic origin of blast hits for each contig, and the search can be restricted to particular taxonomic groups. The database allows access to UniProt annotations, blast output, protein family domains (PFAM) and Gene Ontology. The database will allow users to search for genetic markers and identifying candidate genes or genes for expression analyses. It is open for additional deposition of sequence information for L. saxatilis and other species of the genus Littorina. The LSD is available at http://mbio-serv2.mbioekol.lu.se/Littorina/.
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| 45. |
- Dewhurst, Richard, et al.
(författare)
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It depends on how you look at it: Scanpath comparison in multiple dimensions with MultiMatch, a vector-based approach
- 2012
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Ingår i: Behavior Research Methods. - : Springer Science and Business Media LLC. - 1554-3528.
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Tidskriftsartikel (refereegranskat)abstract
- Eye movement sequences---or scanpaths---vary depending on stimulus characteristics and task (Foulsham \& Underwood, 2008; Land, Mennie, \& Rusted, 1999). Common methods for comparing scanpaths, however, are limited in their ability to capture both the spatial and temporal properties of which a scanpath consists. Here we validate a new method for scanpath comparison based on geometric vectors, which compares scanpaths over multiple dimensions retaining positional and sequential information (Jarodzka, Holmqvist, \& Nyström, 2010). `MultiMatch' was tested in two experiments and pitted against ScanMatch (Cristino, Mathôt, Theeuwes, \& Gilchrist, 2010), the most comprehensive adaptation of the popular Levenshtein method. Experiment 1 used synthetic data, demonstrating the greater sensitivity of MultiMatch to variations in spatial position. In experiment 2 real eye movement recordings were taken from participants viewing sequences of dots, designed to elicit scanpath pairs with commonalities known to be problematic for algorithms (for example, when one scanpath is shifted in locus, or fixations fall either side of an AOI boundary). Results illustrate the advantages of a multidimensional approach, revealing how two scanpath differ. For instance, if one scanpath is the reverse copy of another the difference is in direction but not the position of fixations; or if a scanpath is scaled down, the difference is in the length of saccadic vectors but not overall shape. As well as having enormous potential for any task in which consistency in eye movements is important (e.g. learning), MultiMatch is particularly relevant for "eye movements to nothing" in mental imagery research and embodiment of cognition, where satisfactory scanpath comparison algorithms are lacking.
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| 46. |
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| 47. |
- Di Leo, D., et al.
(författare)
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On the impact of hardware faults - An investigation of the relationship between workload inputs and failure mode distributions
- 2012
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Ingår i: Lect. Notes Comput. Sci.. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 9783642336775 ; , s. 198-209
-
Konferensbidrag (refereegranskat)abstract
- Technology scaling of integrated circuits is making transistors increasingly sensitive to process variations, wear-out effects and ionizing particles. This may lead to an increasing rate of transient and intermittent errors in future microprocessors. In order to assess the risk such errors pose to safety critical systems, it is essential to investigate how temporary errors in the instruction set architecture (ISA) registers and main memory locations influence the behaviour of executing programs. To this end, we investigate - by means of extensive fault injection experiments - how such errors affect the execution of four target programs. The paper makes three contributions. First, we investigate how the failure modes of the target programs vary for different input sets. Second, we evaluate the error coverage of a software-implemented hardware fault tolerant technique that relies on triple-time redundant execution, majority voting and forward recovery. Third, we propose an approach based on assembly language metrics which can be used to correlate the dynamic fault-free behaviour of a program with its failure mode distribution obtained by fault injection.
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| 48. |
- Duell, Eric J, et al.
(författare)
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Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
- 2011
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 94:5, s. 1266-75
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Gastric cancer (GC) is the second leading cause of cancer death worldwide. The association between alcohol consumption and GC has been investigated in numerous epidemiologic studies with inconsistent results. OBJECTIVE: We evaluated the association between alcohol consumption and GC risk. DESIGN: We conducted a prospective analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 444 cases of first primary gastric adenocarcinoma. HRs and 95% CIs for GC were estimated by using multivariable Cox proportional hazards regression for consumption of pure ethanol in grams per day, with stratification by smoking status, anatomic subsite (cardia, noncardia), and histologic subtype (diffuse, intestinal). In a subset of participants, results were further adjusted for baseline Helicobacter pylori serostatus. RESULTS: Heavy (compared with very light) alcohol consumption (≥60 compared with 0.1-4.9 g/d) at baseline was positively associated with GC risk (HR: 1.65; 95% CI: 1.06, 2.58), whereas lower consumption amounts (<60 g/d) were not. When we analyzed GC risk by type of alcoholic beverage, there was a positive association for beer (≥30 g/d; HR: 1.75; 95% CI: 1.13, 2.73) but not for wine or liquor. Associations were primarily observed at the highest amounts of drinking in men and limited to noncardia subsite and intestinal histology; no statistically significant linear dose-response trends with GC risk were observed. CONCLUSION: Heavy (but not light or moderate) consumption of alcohol at baseline (mainly from beer) is associated with intestinal-type noncardia GC risk in men from the EPIC cohort.
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| 49. |
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| 50. |
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Entrepreneurship, social capital and governance : Directions for the sustainable development and competitiveness of regions
- 2012. - 1
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This book highlights the role of entrepreneurship, social capital and governance for regional economic development. In recent decades, many researchers have claimed that entrepreneurship is the most critical factor in sustaining regional economic growth. However, most entrepreneurship research is undertaken without considering the fundamental importance of the regional context. Other research has emphasized the role of social capital but there are substantial problems in empirically relating measures of social capital to regional economic development. © Charlie Karlsson, Börje Johansson and Roger R. Stough 2012. All rights reserved.
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