| 91. |
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| 92. |
- Thorgeirsson, Thorgeir E, et al.
(author)
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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
- 2008
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 452:7187, s. 9-638
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Journal article (peer-reviewed)abstract
- Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year(1,2). Evidence for genetic influence on smoking behaviour and nicotine dependence (ND)(3-8) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health(9,10). Smoking is the major risk factor for lung cancer (LC)(11-14) and is one of the main risk factors for peripheral arterial disease (PAD)(15-17). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking- related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genomewide association study that used low- quantity smokers as controls(18,19), and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene - environment interaction(20), highlighting the role of nicotine addiction in the pathology of other serious diseases.
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| 93. |
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| 94. |
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| 95. |
- Wadsworth, R., et al.
(author)
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THE NORTHWEST FRONTIER : SPECTROSCOPY OF N similar to Z NUCLEI BELOW MASS 100
- 2009
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In: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 40:3, s. 611-620
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Journal article (peer-reviewed)abstract
- The spectroscopy and structure of excited states of N similar to Z nuclei in the mass 70-100 region has been investigated using two techniques. In the A similar to 70-80 region fusion evaporation reactions coupled with the recoil-beta-tagging method have been employed at Jyvaskyla to study low-lying states in odd-odd N = Z nuclei. Results from these and other data for known odd-odd nuclei above mass 60 will be discussed. In the heavier mass 90 region a fragmentation experiment has been performed using the RIS-ING/FRS setup at GSI. This experiment was primarily aimed at searching for spin gap isomers in nuclei around A similar to 96. The objectives of the latter experiment will be discussed.
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| 96. |
- Walker, Tony R., et al.
(author)
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Multiple indicators of human impacts on the environment in the Pechora Basin, north-eastern European Russia
- 2009
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In: Ecological Indicators. - : Elsevier BV. - 1470-160X .- 1872-7034. ; 9:4, s. 765-779
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Journal article (peer-reviewed)abstract
- The Pechora Region (PR) has extensive natural resources supporting forestry, oil and gas industries. The objective of this integrated study was to identify if local and long range pollution and biodiversity impacts were detectable on a regional scale using multi-indicators by selecting paired sites, close to industrial/forestry activities and in 'reference' areas (remote from any industrial centers, settlements or commercial activities). Chemistry of lichens, topsoil, lake water and sediments, plus diversity of lichens, birds and aquatic indicators along with landscape analysis were measured at eight sites in the PR to assess local impacts of oil/gas and forestry operations. Furthermore, an analysis of water and sediment chemistry was made at river stations and sites within the Pechora Delta. Local areas around industrial towns of Vorkuta and Usinsk showed increased pollution and decreased biodiversity. Among remote areas, subtle changes in pollution and biodiversity were detected close to oil/gas operations on the Kolva and Ortina Rivers, indicating early signs of environmental impact. Delta analyses showed limited impacts and most other sites remained unmodified reflecting low ecological impacts. Changes in forest landscape structure over large areas were apparently too small to cause significant negative impacts on bird diversity. This was the first attempt showing how multi-indicators can be used over broad spatial scales to assess environmental impacts in the PR.
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| 97. |
- Wiseman, D. R., et al.
(author)
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In-beam gamma-ray spectroscopy of Po-190,Po-197
- 2007
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In: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 34:3, s. 275-281
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Journal article (peer-reviewed)abstract
- gamma-ray transitions in the neutron-deficient nuclei Po-190,Po-197 have been identified using the JUROGAM Ge detector array coupled to the RITU gas-filled separator and the GREAT spectrometer. The yrast band of Po-190 has been firmly established through gamma-gamma coincidences and extended up to a spin and parity of 14(+). It displays similar behaviour to its isotones Hg-186 and Pb-188 above the 4(+) level, thus confirming its prolate nature. In Po-197 the band built upon the 13/2(+) isomer has been extended up to a spin and parity of 33/2(+), while the non-yrast band has been observed for the first time. The behaviour of Po-197 is found to be similar to that of the nearby even-mass isotopes, which is consistent with the model in which the i(13/2) neutron is weakly coupled to the states in the even-even core.
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| 98. |
- Wiseman, D. R., et al.
(author)
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Probe of triple shape coexistence in neutron deficient polonium nuclei
- 2006
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In: AIP Conf. Proc.. - : AIP. - 0735403236 - 9780735403239 ; , s. 560-562
-
Conference paper (peer-reviewed)abstract
- γ-ray transitions in the neutron deficient 190,197Po nuclei have been identified. The yrast band of 190Po has been extended up to a spin and parity of 14+ and is found to display similar systematic behaviour to isotones 186Hg and 188Pb above the 4+ level, thus confirming its prolate nature. In 197Po the band built upon the 13/2+ isomer has been extended up to a spin and parity of 33/2+, while the non-yrast side-band has been observed for the first time. The behaviour of 197Po is found to be similar to that of the nearby even-mass isotopes, which is consistent with the model in which the i13/2 neutron is weakly coupled to the states in the even-even core.
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| 99. |
- Wolff, M.A., et al.
(author)
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Validation of HNO3, ClONO2 and N2O5 from the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS)
- 2008
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In: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 8:13, s. 3529-3562
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Journal article (peer-reviewed)abstract
- The Atmospheric Chemistry Experiment (ACE) satellite was launched on 12 August 2003. Its two instruments measure vertical profiles of over 30 atmospheric trace gases by analyzing solar occultation spectra in the ultraviolet/visible and infrared wavelength regions. The reservoir gases HNO3, ClONO2, and N2O5 are three of the key species provided by the primary instrument, the ACE Fourier Transform Spectrometer (ACE-FTS). This paper describes the ACE-FTS version 2.2 data products, including the N2O5 update, for the three species and presents validation comparisons with available observations. We have compared volume mixing ratio (VMR) profiles of HNO3, ClONO2, and N2O5 with measurements by other satellite instruments (SMR, MLS, MIPAS), aircraft measurements (ASUR), and single balloon-flights (SPIRALE, FIRS-2). Partial columns of HNO3 and ClONO2 were also compared with measurements by ground-based Fourier Transform Infrared (FTIR) spectrometers. Overall the quality of the ACE-FTS v2.2 HNO3 VMR profiles is good from 18 to 35 km. For the statistical satellite comparisons, the mean absolute differences are generally within ±1 ppbv ±20%) from 18 to 35 km. For MIPAS and MLS comparisons only, mean relative differences lie within±10% between 10 and 36 km. ACE-FTS HNO3 partial columns (~15–30 km) show a slight negative bias of −1.3% relative to the ground-based FTIRs at latitudes ranging from 77.8° S–76.5° N. Good agreement between ACE-FTS ClONO2 and MIPAS, using the Institut für Meteorologie und Klimaforschung and Instituto de Astrofísica de Andalucía (IMK-IAA) data processor is seen. Mean absolute differences are typically within ±0.01 ppbv between 16 and 27 km and less than +0.09 ppbv between 27 and 34 km. The ClONO2 partial column comparisons show varying degrees of agreement, depending on the location and the quality of the FTIR measurements. Good agreement was found for the comparisons with the midlatitude Jungfraujoch partial columns for which the mean relative difference is 4.7%. ACE-FTS N2O5 has a low bias relative to MIPAS IMK-IAA, reaching −0.25 ppbv at the altitude of the N2O5 maximum (around 30 km). Mean absolute differences at lower altitudes (16–27 km) are typically −0.05 ppbv for MIPAS nighttime and ±0.02 ppbv for MIPAS daytime measurements.
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