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41.	Josephson, F., et al. (författare) CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels 2008 Ingår i: European Journal of Clinical Pharmacology. - : Springer Science and Business Media LLC. - 0031-6970 .- 1432-1041. ; 64:8, s. 775-81 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE AND METHODS: A member of the major human cytochrome P450 superfamily of hemoproteins, CYP3A4/5, converts cholesterol into 4beta-hydroxycholesterol. We studied plasma 4beta-hydroxycholesterol levels prior to and 4 weeks after initiating antiretroviral therapy that included efavirenz, ritonavir-boosted atazanavir or ritonavir-boosted lopinavir with the aim of exploring the usefulness of plasma 4beta-hydroxycholesterol levels as an endogenous biomarker of CYP3A activity. Efavirenz is an inducer of CYP3A, whereas the ritonavir-boosted regimens are net inhibitors of CYP3A. RESULTS: In patients treated with efavirenz, the median plasma 4beta-hydroxycholesterol level increased by 46 ng/mL (p = 0.004; n = 11). In contrast, patients given ritonavir-boosted atazanavir showed a median decrease in plasma 4beta-hydroxycholesterol of -9.4 ng/mL (p = 0.0003; n = 22), and those given ritonavir-boosted lopinavir showed a median change from baseline of -5.8 ng/mL (p = 0.38; n = 19). There were significant between-group differences in the effects of antiretroviral treatment on plasma 4beta-hydroxycholesterol levels (p < 0.0001). CONCLUSION: Changes in plasma 4beta-hydroxycholesterol following the initiation of efavirenz- or atazanavir/ritonavir-based antiretroviral therapy reflected the respective net increase and decrease of CYP3A activity of these regimens. The plasma 4beta-hydroxycholesterol level did not indicate a net CYP3A inhibition in the lopinavir/ritonavir arm, possibly because of concomitant enzyme induction.
42.	Josephson, F, et al. (författare) CYP3A5 genotype has an impact on the metabolism of the HIV protease inhibitor saquinavir 2007 Ingår i: Clinical pharmacology and therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 81:5, s. 708-712 Tidskriftsartikel (refereegranskat)
43.	Josephson, M, et al. (författare) Differences in the association between psychosocial work conditions and physical work load in female- and male-dominated occupations. MUSIC-Norrtälje Study Group 1999 Ingår i: American Industrial Hygiene Association journal. - : Informa UK Limited. - 0002-8894. ; 60:5, s. 673-678 Tidskriftsartikel (refereegranskat)
44.	Josephson, M, et al. (författare) Paid and unpaid work, and its relation to low back and neck/shoulder disorders among women 2003 Ingår i: Women & health. - 0363-0242. ; 37:2, s. 17-30 Tidskriftsartikel (refereegranskat)
45.	Karlsson, TE, et al. (författare) Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain 2013 Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4, s. e60892- Tidskriftsartikel (refereegranskat)
46.	Karlstrom, O, et al. (författare) Early virologic rebound in a pilot trial of ritonavir-boosted atanazavir as maintenance monotherapy - Reply 2007 Ingår i: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. - 1525-4135. ; 46:1, s. 118-119 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
47.	Karlstrom, O, et al. (författare) Early virologic rebound in a pilot trial of ritonavir-boosted atazanavir as maintenance monotherapy 2007 Ingår i: Journal of acquired immune deficiency syndromes (1999). - 1525-4135. ; 44:4, s. 417-422 Tidskriftsartikel (refereegranskat)
48.	Kjell, J, et al. (författare) Rat substrains differ in the magnitude of spontaneous locomotor recovery and in the development of mechanical hypersensitivity after experimental spinal cord injury 2013 Ingår i: Journal of neurotrauma. - : Mary Ann Liebert Inc. - 1557-9042 .- 0897-7151. ; 30:21, s. 1805-1811 Tidskriftsartikel (refereegranskat)
49.	Kjell, J, et al. (författare) Spatial and cellular characterization of mTORC1 activation after spinal cord injury reveals biphasic increase mainly attributed to microglia/macrophages 2014 Ingår i: Brain pathology (Zurich, Switzerland). - : Wiley. - 1750-3639 .- 1015-6305. ; 24:6, s. 557-567 Tidskriftsartikel (refereegranskat)
50.	Kligfield, Paul, et al. (författare) Recommendations for the standardization and interpretation of the electrocardiogram: part I: The electrocardiogram and its technology: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology 2007 Ingår i: Circulation. - 1524-4539. ; 115:10, s. 1306-1324 Tidskriftsartikel (refereegranskat)abstract This statement examines the relation of the resting ECG to its technology. Its purpose is to foster understanding of how the modern ECG is derived and displayed and to establish standards that will improve the accuracy and usefulness of the ECG in practice. Derivation of representative waveforms and measurements based on global intervals are described. Special emphasis is placed on digital signal acquisition and computer-based signal processing, which provide automated measurements that lead to computer-generated diagnostic statements. Lead placement, recording methods, and waveform presentation are reviewed. Throughout the statement, recommendations for ECG standards are placed in context of the clinical implications of evolving ECG technology.

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Författare/redaktör: Josephson, A (31); Olson, L (16); Spenger, C (11); Brene, S (7); Josephson, F (7); Trifunovski, A (6); visa fler...; Widenfalk, J (5); Josephson, M (5); Sonnerborg, A (4); Pahlm, Olle (4); Karlsson, TE (4); MacFarlane, Peter (4); Vingard, E (4); Kligfield, Paul (4); Wiebe, S. (4); Rautaharju, Pentti (4); Kors, Jan A. (4); Hjelm, EW (4); Josephson, C. B. (4); Sharma, R (3); Hindricks, Gerhard (3); Abrams, MB (3); Kjell, J (3); Singh, S (3); Theorell, T (3); Blomström-Lundqvist, ... (3); Boriani, Giuseppe (3); Karlstrom, O. (3); Malmgren, Kristina, ... (3); Pappone, Carlo (3); Malmborg, Helena (3); Cosio, Francisco G. (3); Wiktorin, C (3); Nordquist, J. (3); Kuck, Karl-Heinz (3); Sundberg, K (3); Pillay, N (3); Themistoclakis, Saki ... (3); Lane, Deirdre A (3); Jais, Pierre (3); Reeves, S. (3); Sajobi, T. T. (3); Wahby, S. (3); Lawal, O. A. (3); Nguyen, D. K. (3); Atkinson, M. J. (3); Hader, W. J. (3); Macrodimitris, S. (3); Starreveld, Y. (3); Josephson, Mark E (3); visa färre...

Lärosäte: Karolinska Institutet (47); Lunds universitet (11); Göteborgs universitet (8); Uppsala universitet (7); Umeå universitet (2); Stockholms universitet (2); visa fler...; Kungliga Tekniska Högskolan (1); Linköpings universitet (1); Sveriges Lantbruksuniversitet (1); visa färre...

Språk: Engelska (68)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (22); Naturvetenskap (1); Samhällsvetenskap (1)

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