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Sökning: WFRF:(Kahn RS)

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  • McLaughlin, RL, et al. (författare)
  • Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
  • 2017
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8, s. 14774-
  • Tidskriftsartikel (refereegranskat)abstract
    • We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05–21.6; P=1 × 10−4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10−7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08–1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
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  • Selten, JP, et al. (författare)
  • No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel
  • 2003
  • Ingår i: Schizophrenia Research. - 0920-9964. ; 63:1-2, s. 131-135
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: Maternal stress during pregnancy is a possible risk factor for schizophrenia in the offspring. Using data from the Israel Psychiatric Registry we examined the impact of wars in Israel. Method: Retrospective birth cohort study. Results: Relative risks for cohorts exposed to Six-Day War and Yom Kippur War were 0.98 (95% CI: 0.85-1.13) and 1.00 (0.86-1.16). Conclusion: The evidence for maternal stress as a risk factor for schizophrenia remains insufficient. (C) 2002 Elsevier Science B.V. All rights reserved.
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39.
  • Selten, JP, et al. (författare)
  • Odegaard's selection hypothesis revisited: Schizophrenia in Surinamese immigrants to the Netherlands
  • 2002
  • Ingår i: American Journal of Psychiatry. - 1535-7228. ; 159:4, s. 669-671
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective. The incidence of schizophrenia among Surinamese immigrants to the Netherlands is high. The authors tested Odegaard's hypothesis that this phenomenon is explained by selective migration. Method: The authors imagined that migration from Surinam to the Netherlands subsumed the entire population of Surinam and not solely individuals at risk for schizophrenia, They compared the risk of a first admission to a Dutch mental hospital for schizophrenia from 1983 to 1992 for Surinamese-born immigrants to the risk for Dutch-born individuals, using the Surinamese-born population in the Netherlands and the population of Surinam combined as the denominator for the immigrants. Results: The age- and sex-adjusted relative risk of schizophrenia for the Surinamese-born immigrants was 1.46. Conclusions: Selective migration cannot solely explain the higher incidence of schizophrenia in Surinamese immigrants to the Netherlands.
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  • Resultat 31-40 av 47

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