| 591. |
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| 592. |
- Yang, Yaohua, et al.
(författare)
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Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk
- 2019
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Ingår i: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 79:3, s. 505-517
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Tidskriftsartikel (refereegranskat)abstract
- DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N = 1,595) were used to build genetic models to predict DNA methylation levels. These prediction models were then applied to the summary statistics of a genome-wide association study (GWAS) of ovarian cancer including 22,406 EOC cases and 40,941 controls to investigate genetically predicted DNA methylation levels in association with EOC risk. Among 62,938 CpG sites investigated, genetically predicted methylation levels at 89 CpG were significantly associated with EOC risk at a Bonferroni-corrected threshold of P < 7.94 x 10(-7). Of them, 87 were located at GWAS-identified EOC susceptibility regions and two resided in a genomic region not previously reported to be associated with EOC risk. Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely MAPT, HOXB3, ABHD8, ARHGAP27, and SKAP1. We identified novel DNA methylation markers associated with EOC risk and propose that methylation at multiple CpG may affect EOC risk via regulation of gene expression. Significance: Identification of novel DNA methylation markers associated with EOC risk suggests that methylation at multiple CpG may affect EOC risk through regulation of gene expression.
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| 593. |
- Bhattacharjee, Rahul, et al.
(författare)
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Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances : Current insights and perspectives
- 2022
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Ingår i: Materials & design. - : Elsevier. - 0264-1275 .- 1873-4197. ; 224
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Tidskriftsartikel (refereegranskat)abstract
- Genetic editing technologies have emerged as a potential therapeutic tool in various biomedical fields owing to their applications against cancer, neurological diseases, diabetes, autoimmune disorder, muscu-lar dystrophy, bacterial infections (AMR), and cardiovascular diseases. CRISPR is one such valuable genetic editing tool with extensive therapeutic appliances but with a major challenge in terms of deliv-ery. Herein, we have strived to exploit a synergy of nanocarriers and CRISPR against the aforementioned diseases for their medical applications and explicated their clinical significance including the enhanced delivery via endosomal escape and environmental factors such as light, pH, and stimuli. In addition to highlighting the delivery strategies of nano-carriers for CRISPR and their characterization, we have expounded on the reliant factor of the CRISPR-Cas Complex.
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| 594. |
- Bhugra, Dinesh, et al.
(författare)
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World Psychiatric Association-Asian journal of psychiatry commission on psychiatric education in the 21st century
- 2023
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Ingår i: Asian Journal of Psychiatry. - : Elsevier. - 1876-2018 .- 1876-2026. ; 88
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Tidskriftsartikel (refereegranskat)abstract
- Psychiatric practice faces many challenges in the first quarter of 21st century. Society has transformed, as have training requirements and patient expectations, underlining an urgent need to look at educational programmes. Meanwhile, awareness has grown around psychiatric disorders and there are evolving workforce trends, with more women going to medical school and specialising in psychiatry. Trainee psychiatrists carry different expectations for work-life balance and are increasingly becoming conscious of their own mental health. A tendency to see health as a commodity and the litigious nature of society has elicited additional pressures for healthcare professionals. Cartesian mind-body dualism has created further complexity and this can often be frustrating for patients and care-partners alike. In many cultures across Asia and beyond, patients can present with physical symptoms to express underlying psychological distress with increasing physical investigations. Simultaneously, in various countries, a shift from asylums to community-based interventions and then home treatments have changed psychiatric care in remarkable ways. These changes have added to pressures faced by mental healthcare professionals. However, trainees and other mental healthcare professionals continue to receive similar training as they did a generation ago. The tensions and differences in ideology/orientation between different branches of psychiatry have made responses to patient needs challenging. Recognising that it is difficult to predict the future, this World Psychiatric Association-Asian Journal of Psychiatry Commission makes recommendations that could help institutions and individuals enhance psychiatric education. This Commission draws from existing resources and recent developments to propose a training framework for future psychiatrists.
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| 595. |
- Campbell, S., et al.
(författare)
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Frequency-doubling in femtosecond laser inscribed periodically-poled potassium titanyl phosphate waveguides
- 2007
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Ingår i: Optics Express. - 1094-4087. ; 15:25, s. 17146-17150
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Tidskriftsartikel (refereegranskat)abstract
- Frequency doubling has been achieved in femtosecond-laser-inscribed single-mode waveguides written in two periodically-poled potassium titanyl phosphate crystals. A conversion efficiency of 0.22 %W-1 was obtained for first-order quasi-phase matching at 980 nm and an efficiency of 0.02 %W-1 for third-order quasi-phase matching at 800 nm.
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| 596. |
- Campbell, S., et al.
(författare)
-
Frequency doubling in femtosecond-written periodically-poled potassium titanyl phosphate waveguides
- 2007
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Ingår i: Lasers and Electro-Optics, 2007 European Conference on and the International Quantum Electronics Conference. - 1424409306 - 9781424409303 ; , s. 4386106-
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Konferensbidrag (refereegranskat)abstract
- The second-harmonic conversion efficiency within the PPKTP waveguide is investigated using two separate tunable CW Ti:sapphire lasers at 800 nm and 980 nm. Results show strong conversion efficiency which imply that the local damage-induced index modification does not adversely affect the periodic domain structure in the material.
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| 597. |
- Campbell, S., et al.
(författare)
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Frequency doubling in femtosecond-written periodically-poled potassium titanyl phosphate waveguides
- 2007
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Ingår i: Conference on Lasers and Electro-Optics, 2007, CLEO 2007. - 9781557528346 ; , s. 4452462-
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Konferensbidrag (refereegranskat)abstract
- Frequency doubling is demonstrated in femtosecond-laser-created single-mode waveguides written in a periodically-poled potassium titanyl phosphate crystal. Conversion efficiencies of 0.22%/W (0.02%/W) were obtained for first (third) order phasematching at 980nm (800nm).
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| 598. |
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| 599. |
- Gustafson, Gösta, et al.
(författare)
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Multi-Parton Interactions at the LHC
- 2011
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We review the recent progress in the theoretical description and experimental observation of multiple parton interactions. Subjects covered include experimental measurements of minimum bias interactions and of the underlying event, models of soft physics implemented in Monte Carlo generators, developments in the theoretical description of multiple parton interactions and phenomenological studies of double parton scattering. This article stems from contributions presented at the Helmholtz Alliance workshop on ”Multi-Parton Interactions at the LHC”, DESY Hamburg, 13-15 September 2010.
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| 600. |
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