| 31. |
- Karlsson, Stefan, 1984-, et al.
(författare)
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Dataset: Mechanical, thermal, and structural investigations of chemically strengthened Na2O–CaO–Al2O3–SiO2 glasses
- 2022
-
Annan publikationabstract
- We investigated the effect of alumina doping on thermal, mechanical, and structural properties of a conventional soda lime silicate glass before and after ion exchange strengthening. The techniques to measure properties were:- 23Na and 27Al Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR)- Scattered light polariscope- Differential Thermal Analysis (DTA)- Nanoindentation- MicroindentationMore detailed information can be found in the documentation-readme file.
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| 32. |
- Karlsson, Stefan, 1984-, et al.
(författare)
-
Mechanical, thermal, and structural investigations of chemically strengthened Na2O-CaO-Al2O3-SiO2 glasses
- 2022
-
Ingår i: Frontiers in Materials. - : Frontiers Media S.A.. - 2296-8016. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- For a series of conventional soda-lime-silicate glasses with increasing Al2O3 content, we investigated the thermal, mechanical, and structural properties before and after K+-for-Na+ ion-exchange strengthening by exposure to molten KNO3. The Al-for-Si replacement resulted in increased glass network polymerization and lowered compactness. The glass transition temperature (T (g)), hardness (H) and reduced elastic modulus (E (r)), of the pristine glasses enhanced monotonically for increasing Al2O3 content. H and E (r) increased linearly up to a glass composition with roughly equal stoichiometric amounts of Na2O and Al2O3 where a nonlinear dependence on Al2O3 was observed, whereas H and E (r) of the chemically strengthened (CS) glasses revealed a strictly linear dependence. T (g), on the other hand, showed linear increase with Al-for-Si for pristine glasses while for the CS glasses a linear to nonlinear trend was observed. Solid-state Al-27 nuclear magnetic resonance (NMR) revealed the sole presence of AlO4 groups in both the pristine and CS glasses. Na-23 NMR and wet-chemical analysis manifested that all Al-bearing glasses had a lower and near-constant K+-for-Na+ ion exchange ratio than the soda-lime-silicate glass. Differential thermal analysis of CS glasses revealed a "blurred " glass transition temperature (T (g)) and an exothermic step below T (g); the latter stems from the relaxation of residual compressive stresses. The nanoindentation-derived hardness at low loads and n(M O-(2))/n(Al2O3) & AP; 1 for the CS glasses, which is attributed to an increased elastic energy recovery that is linked to the glass compactness.
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| 33. |
- Lehtveer, Mariliis, 1983, et al.
(författare)
-
Actuating the European Energy System Transition: Indicators for Translating Energy Systems Modelling Results into Policy-Making
- 2021
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Ingår i: Frontiers in Energy Research. - : Frontiers Media SA. - 2296-598X. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, we define indicators, with a focus on the electricity sector, that translate the results of energy systems modelling to quantitative entities that can facilitate assessments of the transitions required to meet stringent climate targets. Such indicators, which are often overlooked in model scenario presentations, can be applied to make the modelling results more accessible and are useful for managing the transition on the policy level, as well as for internal evaluations of modelling results. We propose a set of 13 indicators related to: 1) the resource and material usages in modelled energy system designs; 2) the rates of transition from current to future energy systems; and 3) the energy security in energy system modelling results. To illustrate its value, the proposed set of indicators is applied to energy system scenarios derived from an electricity system investment model for Northern Europe. We show that the proposed indicators are useful for facilitating discussions, raising new questions, and relating the modelling results to Sustainable Development Goals and thus facilitate better policy processes. The indicators presented here should not be seen as a complete set, but rather as examples. Therefore, this paper represents a starting point and a call to other modellers to expand and refine the list of indicators.
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| 34. |
- Lindskog, Carin, 1965-
(författare)
-
Tensions experienced and balancing strategies used in Agile Software Development environments
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- To achieve efficiency in rapidly changing environments, working methods that promote change and flexibility are needed. Thus, the Agile ways of working (i.e. Agile values, principles, and frameworks) are today the most common approach to developing software and something that is currently spreading to many other industries and organizations outside of the traditional IT sector. However, it is challenging to combine the business-driven need for predictability and planning with the Agile ways of working, e.g. changeability, self-management and step-by-step development and delivery; therefore, several tensions can arise at the team and organizational levels. Tensions can, for example, be experienced if the team members’ experiences are rooted in traditional project environments with stable processes and predefined requirements based on detailed planning. This dissertation aims to contribute to our knowledge of Agile Software Development (ASD) by examining the contradictions and tensions in ASD environments, as well as how to balance and react to these tensions. The dissertation responds to the great need for conceptual development in the field of Information Systems. The target groups are both researchers and practitioners.The research reported on in this dissertation is based on one conceptual study and two empirical studies. The studies reported on in four appended papers jointly contribute toward answering three research questions (RQs):RQ 1: What is the nature of the tensions experienced in ASD environments?RQ 2: What are the sources of the tensions experienced in ASD environments?RQ 3: What ambidextrous strategies can be used to both balance and react to the tensions found in ASD environments?This dissertation brings together concepts from academic domains of knowledge (organizational theories of [paradoxical] tensions and ambidexterity and Activity Theory derived from socio-psychological theory) in order to provide a new insight into the complexity of ASD.This dissertation contributes by discussing and visualizing how patterns of contradictions, categorized tensions and ambidextrous (i.e. the ability to manage two seemingly contradictory activities) strategies have been compiled and connected. This dissertation also contributes by describing how three models that can be used to develop the concept of “shared mental models”, which is so important to team-based learning.
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| 35. |
- Mattsson, Sandra, 1984, et al.
(författare)
-
Comparing quantifiable methods to measure complexity in assembly
- 2014
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Ingår i: International Journal of Manufacturing Research. - 1750-0591 .- 1750-0605. ; 9:1, s. 112-130
-
Tidskriftsartikel (refereegranskat)abstract
- In order to measure complexity and stay competitive, manufacturing companies need to be able to quantify production complexity. For this reason, two methods were developed within the context of two concurrent research projects are compared: the Belgian Complexity Calculator, CXC, measures objective complexity and the Swedish Complexity Index, CXI, focuses on subjective complexity, as experienced by operators in the stations. This paper presents a comparative analysis of the two methods by comparing them to seven relevant existing quantitative methods and by examining results from case studies. It is observed that the two methods can be used as a compliment to one another, where CXC can be used for scanning data automatically CXI can be used for in-depth analysis. In addition, the comparison of existing methods provides insight on how to measure complexity depending on need and scope.
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| 36. |
- Mattsson, Sandra, 1984, et al.
(författare)
-
Validation of the complexity index method at three manufacturing companies
- 2013
-
Ingår i: Proceedings - 2013 IEEE International Symposium on Assembly and Manufacturing, ISAM 2013. - 9781479916573 ; , s. 55-57
-
Konferensbidrag (refereegranskat)abstract
- In order to manage increasing numbers of product variants, tools that can reduce or manage production complexity are vital. The paper describes CompleXity Index (CXI), an index-based method and tool that assess the complexity at an industrial workstation. CXI was validated at three Swedish manufacturing companies investigating how different roles affect the index calculation and if the method measures what was intended. In all three cases, CXI was seen as a useful tool that provided a holistic view of the problems seen at a station. In addition it was indicated that complexity and unbalanced work was connected and that the method could be used to predict problem areas on new stations.
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| 37. |
- Norman-Monroe, Therese, 1984-
(författare)
-
Transport accessibility, wholesale trade and spatial development
- 2017
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis comprises four independent papers, which all explore some aspect of the relationship between accessibility and spatial development. The central question I pose is how improved accessibility to transportation services, human capital, jobs, or the market contributes to the spatial variation in economic development. Empirical data and estimations are utilized in all chapters.The first paper (co-authored with Johan Klaesson) explores how a regional accessibility model can be used to analyze the growth of knowledge-intensive industries on a detailed geographical scale compared to a broader definition.In the second paper (co-authored with Maria Börjesson and Christer Anderstig), a refined accessibility measure is used to estimate the magnitude of the causal effect of transport system investments on the unemployment rate, and whether the effect differs for people with different levels of education.The third paper addresses the role that access to transportation services plays for wholesale start-ups, particularly in regions lacking in local demand.The analysis in paper number four covers the same time period as the advancement of the Internet, which greatly reduced transaction costs. The paper examines the importance of access to human capital for the spatial reorganization and growth of wholesale industries during this time period.
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| 38. |
- Olsén, Johan Staby, et al.
(författare)
-
Predicting toxicity caused by high-dose-rate brachytherapy single boost for prostate cancer
- 2022
-
Ingår i: Journal of Contemporary Brachytherapy. - : Termedia sp. z o.o.,Termedia Publishing House. - 1689-832X .- 2081-2841. ; 14:1, s. 7-14
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: Treating localized prostate cancer (PC) with combination radiotherapy consisting of external beam radiotherapy (EBRT) and high-dose-rate brachytherapy (HDR-BT) has been proven to result in better disease outcome than EBRT only. We aimed to evaluate the incidence of toxicities due to combination therapy and identify parameters correlated to acute or late urinary, rectal, and erectile toxicities.Material and methods: Data on symptoms and tumor/treatment parameters were collected from 359 patients treated between 2008 and 2018 with EBRT (42 Gy in 14 fractions) and HDR-BT (14.5 Gy in one fraction) for localized PC, at the Örebro University Hospital. Urinary, rectal, and erectile symptoms were presented descriptively, and bivariate analyses for correlation between grade ≥ 2 toxicity and potential predictors were performed. To evaluate prognostic models, multivariable analyses were applied.Results: Urinary toxicity grade ≥ 2 was observed in 154 patients (47% of patients without pre-existing symptoms grade ≥ 2), of which 15 were grade 3. Rectal toxicity grade 2 was observed in 22 (6%) patients. Any grade erectile dysfunction was evident in all patients without pre-existing dysfunction (n = 103), whereas only 7 recovered completely. In bivariate analyses age was correlated with higher risk of acute urinary toxicity, and irradiated volume was associated with both urinary and rectal toxicities. However, we found no multivariable model of clinical and statistical significance to predict the risk of urinary or rectal toxicities.Conclusions: In our study cohort, the severity of toxicities was in general mild or moderate and temporary, whereas the incidence of severe toxicity was considerably low. Although we found no predictive models for toxicities, our findings are reassuring that this treatment approach as curative therapy for localized PC is well-tolerated.
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| 39. |
- Qvick, Alvida, 1990-, et al.
(författare)
-
Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer
- 2021
-
Ingår i: Molecular Medicine. - : Springer. - 1076-1551 .- 1528-3658. ; 27:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The aim of this study was to investigate the clinical value of liquid biopsy as a primary source for variant analysis in lung cancer. In addition, we sought to characterize liquid biopsy variants and to correlate mutational load to clinical data.Methods: Circulating cell-free DNA was extracted from plasma from patients with lung cancer (n = 60) and controls with benign lung disease (n = 16). Variant analysis was performed using the AVENIO ctDNA Surveillance kit and the results were correlated to clinical and variant analysis data from tumor tissue or cytology retrieved from clinical routine diagnostics.Results: There were significantly more variants detected in lung cancer cases compared to controls (p = 0.011), but no difference between the histological subgroups of lung cancer was found (p = 0.465). Furthermore, significantly more variants were detected in patients with stage IIIb-IV disease compared to patients with stage I-IIIa (median 7 vs 4, p = 0.017). Plasma cfDNA mutational load was significantly associated with overall survival (p = 0.010). The association persisted when adjusted for stage and ECOG performance status (HR: 3.64, 95% CI 1.37-9.67, p = 0.009). Agreement between tumor and plasma samples significantly differed with stage; patients with stage IIIb-IV disease showed agreement in 88.2% of the cases with clinically relevant variants, compared to zero cases in stage I-IIIa (p = 0.004). Furthermore, one variant in EGFR, two in KRAS, and one in BRAF were detected in plasma but not in tumor samples.Conclusion: This study concludes that in the vast majority of advanced NSCLC patients a reliable variant analysis can be performed using liquid biopsy from plasma. Furthermore, we found that the number of variants in plasma is associated with prognosis, possibly indicating a strategy for closer follow up on this crucial patient group.
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| 40. |
- Raphel, J., et al.
(författare)
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Engineered protein coatings to improve the osseointegration of dental and orthopaedic implants
- 2016
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Ingår i: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 83, s. 269-282
-
Tidskriftsartikel (refereegranskat)abstract
- Here we present the design of an engineered, elastin-like protein (ELP) that is chemically modified to enable stable coatings on the surfaces of titanium-based dental and orthopaedic implants by novel photocrosslinking and solution processing steps. The ELP includes an extended RGD sequence to confer bio-signaling and an elastin-like sequence for mechanical stability. ELP thin films were fabricated on cpTi and Ti6A14V surfaces using scalable spin and dip coating processes with photoactive covalent cross linking through a carbene insertion mechanism. The coatings withstood procedures mimicking dental screw and hip replacement stem implantations, a key metric for clinical translation. They promoted rapid adhesion of MG63 osteoblast-like cells, with over 80% adhesion after 24 h, compared to 38% adhesion on uncoated Ti6A14V. MG63 cells produced significantly more mineralization on ELP coatings compared to uncoated Ti6A14V. Human bone marrow mesenchymal stem cells (hMSCs) had an earlier increase in alkaline phosphatase activity, indicating more rapid osteogenic differentiation and mineral deposition on adhesive ELP coatings. Rat tibia and femur in vivo studies demonstrated that cell -adhesive ELP-coated implants increased bone-implant contact area and interfacial strength after one week. These results suggest that ELP coatings withstand surgical implantation and promote rapid osseointegration, enabling earlier implant loading and potentially preventing micromotion that leads to aseptic loosening and premature implant failure.
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