| 51. |
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| 52. |
- Malmi, L., et al.
(författare)
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Developing a methodological taxonomy of EER papers
- 2012
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Ingår i: SEFI 40th Annual Conference 2012; Thessaloniki; Greece; 23 September 2012 through 26 September 2012. - 9782873520052
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Konferensbidrag (refereegranskat)abstract
- Engineering Education Research (EER) is a wide and rich field of investigation [1]. It covers research on learning and teaching in all engineering disciplines as well as in the supporting disciplines, like physics, chemistry, computing and mathematics, which form the scientific basis of engineering research. Moreover, EER draws on theories and research methodologies from social sciences, like education, psychology and sociology to investigate the many-faced aspects of learning and teaching engineering. In order to get a better overview of the whole field, there is a need to look at both what is being researched and how the research is carried out. The authors of this paper met in connection to a series of meetings arranged by the SEFI working group EER and a series of workshops organised by Line B of the EU project EUGENE, and decided to collaborate on the construction of a taxonomy for EER from a European perspective. The overall aim is to develop a taxonomy for the how aspect of EER. More specifically, we aim to identify what kind of theoretical frameworks and research designs that are being used, what kind of data that is collected and how it is analysed in EER papers. Our current analysis focuses on published papers in two major European EER forums: European Journal of Engineering Education and the EER track in the SEFI conference, but the taxonomy can obviously be used to analyse any other EER papers. We hope that this work will better reveal the richness of the field, but also highlight approaches that could be used more often in EER. Moreover, the results can be used to inform authors about differences between various publication forums, and emerging methodological trends in research. Finally, we will also look at how different aspects of research have been reported in EER papers with a view to providing suggestions for improving research reporting. In this paper we describe the taxonomy and how it was developed. The results of the analysis will be reported elsewhere.
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| 53. |
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| 55. |
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| 56. |
- Scott, Robert A., et al.
(författare)
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
- 2017
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 66:11, s. 2888-2902
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Tidskriftsartikel (refereegranskat)abstract
- To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 x 10(-8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and more complete coverage of low-frequency variation, all novel associations were driven by common single nucleotide variants. Credible sets of potentially causal variants were generally larger than those based on imputation with earlier reference panels, consistent with resolution of causal signals to common risk haplotypes. Stratification of T2D-associated loci based on T2D-related quantitative trait associations revealed tissue-specific enrichment of regulatory annotations in pancreatic islet enhancers for loci influencing insulin secretion and in adipocytes, monocytes, and hepatocytes for insulin action-associated loci. These findings highlight the predominant role played by common variants of modest effect and the diversity of biological mechanisms influencing T2D pathophysiology.
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| 57. |
- Spada, Cristiano, et al.
(författare)
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Factors Associated with Polyp Detection Rate in European Colonoscopy Practice : Findings of The European Colonoscopy Quality Investigation (ECQI) Group
- 2022
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 19:6
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Tidskriftsartikel (refereegranskat)abstract
- Background: The European Colonoscopy Quality Investigation (ECQI) Group aims to raise awareness for improvement in colonoscopy standards across Europe. We analysed data collected on a sample of procedures conducted across Europe to evaluate the achievement of the polyp detection rate (PDR) target. We also investigated factors associated with PDR, in the hope of establishing areas that could lead to a quality improvement. Methods: 6445 form completions from 12 countries between 2 June 2016 and 30 April 2018 were considered for this analysis. We performed an exploratory analysislooking at PDR according to European Society of Gastrointestinal Endoscopy (ESGE) definition. Stepwise multivariable logistic regression analysis was conducted to determine the most influential associated factors after adjusting for the other pre-specified variables. Results: In our sample therewere 3365 screening and diagnostic procedures performed in those over 50 years. The PDR was 40.5%, which is comparable with the ESGE minimum standard of 40%. The variables found to be associated with PDR were in descending order: Use of high-definition equipment, body mass index (BMI), patient gender, age group, and the reason for the procedure. Use of HD equipment was associated with a significant increase in the reporting of flat lesions (14.3% vs. 5.7%, p < 0.0001) and protruded lesions (34.7% vs. 25.4%, p < 0.0001). Conclusions: On average, the sample of European practice captured by the ECQI survey meets the minimum PDR standard set by the ESGE. Our findings support the ESGE recommendation for routine use of HD colonoscopy.
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| 58. |
- Spada, Cristiano, et al.
(författare)
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Factors Associated with Withdrawal Time in European Colonoscopy Practice : Findings of the European Colonoscopy Quality Investigation (ECQI) Group
- 2022
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Ingår i: Diagnostics. - : MDPI AG. - 2075-4418. ; 12:2
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Tidskriftsartikel (refereegranskat)abstract
- The European Colonoscopy Quality Investigation (ECQI) Group aims to raise awareness for improvement in colonoscopy standards across Europe. We analyzed data collected on a sample of procedures conducted across Europe to evaluate the achievement of the European Society of Gastrointestinal Endoscopy (ESGE) mean withdrawal time (WT) target. We also investigated factors associated with WT, in the hope of establishing areas that could lead to a quality improvement. Methods: 6445 form completions from 12 countries between 2 June 2016 and 30 April 2018 were considered for this analysis. We performed an exploratory analysis looking at WT according to the ESGE definition. Stepwise multivariable logistic regression analysis was conducted to determine the most influential associated factors after adjusting for the other pre-specified variables. Results: In 1150 qualifying colonoscopies, the mean WT was 7.8 min. Stepwise analysis, including 587 procedures where all inputs were known, found that the variables most associated with mean WT were a previous total colonoscopy in the last five years (p = 0.0011) and the time of day the colonoscopy was performed (p = 0.0192). The main factor associated with a WT < 6 min was the time of day that a colonoscopy was performed. Use of sedation was the main factor associated with a higher propor-tion of WT > 10 min, along with a previous colonoscopy. Conclusions: On average, the sample of European practice captured by the ECQI survey met the minimum standard set by the ESGE. How-ever, there was variation and potential for improvement.
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| 59. |
- Uhlig, Jens, et al.
(författare)
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Table-Top Ultrafast X-Ray Microcalorimeter Spectrometry for Molecular Structure
- 2013
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Ingår i: Physical Review Letters. - 1079-7114. ; 110:13
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Tidskriftsartikel (refereegranskat)abstract
- This work presents an x-ray absorption measurement by use of ionizing radiation generated by a femtosecond pulsed laser source. The spectrometer was a microcalorimetric array whose pixels are capable of accurately measuring energies of individual radiation quanta. An isotropic continuum x-ray spectrum in the few-keV range was generated from a laser plasma source with a water-jet target. X rays were transmitted through a ferrocene powder sample to the detector, whose pixels have average photon energy resolution Delta E = 3.14 eV full-width-at-half-maximum at 5.9 keV. The bond distance of ferrocene was retrieved from this first hard-x-ray absorption fine-structure spectrum collected with an energy-dispersive detector. This technique will be broadly enabling for time-resolved observations of structural dynamics in photoactive systems. DOI: 10.1103/PhysRevLett.110.138302
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