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Sökning: WFRF:(Kruger R)

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  • Smith, N. G., et al. (författare)
  • Global photosynthetic capacity is optimized to the environment
  • 2019
  • Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 22:3, s. 506-517
  • Tidskriftsartikel (refereegranskat)abstract
    • Earth system models (ESMs) use photosynthetic capacity, indexed by the maximum Rubisco carboxylation rate (V-cmax), to simulate carbon assimilation and typically rely on empirical estimates, including an assumed dependence on leaf nitrogen determined from soil fertility. In contrast, new theory, based on biochemical coordination and co-optimization of carboxylation and water costs for photosynthesis, suggests that optimal V-cmax can be predicted from climate alone, irrespective of soil fertility. Here, we develop this theory and find it captures 64% of observed variability in a global, field-measured V-cmax dataset for C-3 plants. Soil fertility indices explained substantially less variation (32%). These results indicate that environmentally regulated biophysical constraints and light availability are the first-order drivers of global photosynthetic capacity. Through acclimation and adaptation, plants efficiently utilize resources at the leaf level, thus maximizing potential resource use for growth and reproduction. Our theory offers a robust strategy for dynamically predicting photosynthetic capacity in ESMs.
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  • Somboro, AM, et al. (författare)
  • NOTA: a potent metallo-β-lactamase inhibitor
  • 2015
  • Ingår i: The Journal of antimicrobial chemotherapy. - : Oxford University Press (OUP). - 1460-2091 .- 0305-7453. ; 70:5, s. 1594-1596
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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  • Taylor, Katherine J, et al. (författare)
  • Serious Long-Term Effects of Head and Neck Cancer from the Survivors' Point of View.
  • 2023
  • Ingår i: Healthcare (Basel, Switzerland). - : MDPI AG. - 2227-9032. ; 11:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the long-term quality of life in this population, 1114 HNCS were asked to state their two most serious long-term effects. A clinician recorded the responses during face-to-face appointments. A list of 15 example problems was provided, but a free text field was also available. A total of 1033 survivors responded to the question. The most frequent problems were 'dry mouth' (DM) (n = 476; 46%), 'difficulty swallowing/eating' (DSE) (n = 408; 40%), 'hoarseness/difficulty speaking' (HDS) (n = 169; 16%), and 'pain in the head and neck' (PHN) (n = 142; 14%). A total of 5% reported no problems. Logistic regression adjusted for age, gender, treatment, and tumor stage and site showed increased odds of reporting DM and DSE for chemo-radiotherapy (CRT) alone compared to surgery alone (odds ratio (OR): 4.7, 95% confidence interval (CI): 2.5-9.0; OR: 2.1, CI: 1.1-3.9), but decreased odds for HDS and PHN (OR: 0.3, CI: 0.1-0.6; OR: 0.2, CI: 0.1-0.5). Survivors with UICC stage IV at diagnosis compared to stage I had increased odds of reporting HDS (OR: 1.9, CI: 1.2-3.0). Laryngeal cancer survivors had reduced odds compared to oropharynx cancer survivors of reporting DM (OR: 0.4, CI: 0.3-0.6) but increased odds of HDS (OR: 7.2, CI: 4.3-12.3). This study provides evidence of the serious long-term problems among HNCS.
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