SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Kruse T) "

Sökning: WFRF:(Kruse T)

  • Resultat 311-320 av 322
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
311.
  •  
312.
  •  
313.
  •  
314.
  •  
315.
  •  
316.
  • Schjørring, O. L., et al. (författare)
  • Intensive care doctors’ preferences for arterial oxygen tension levels in mechanically ventilated patients
  • 2018
  • Ingår i: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172 .- 1399-6576. ; 62:10, s. 1443-1451
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Oxygen is liberally administered in intensive care units (ICUs). Nevertheless, ICU doctors’ preferences for supplementing oxygen are inadequately described. The aim was to identify ICU doctors’ preferences for arterial oxygenation levels in mechanically ventilated adult ICU patients. Methods: In April to August 2016, an online multiple-choice 17-part-questionnaire was distributed to 1080 ICU doctors in seven Northern European countries. Repeated reminder e-mails were sent. The study ended in October 2016. Results: The response rate was 63%. When evaluating oxygenation 52% of respondents rated arterial oxygen tension (PaO2) the most important parameter; 24% a combination of PaO2 and arterial oxygen saturation (SaO2); and 23% preferred SaO2. Increasing, decreasing or not changing a default fraction of inspired oxygen of 0.50 showed preferences for a PaO2 around 8 kPa in patients with chronic obstructive pulmonary disease, a PaO2 around 10 kPa in patients with healthy lungs, acute respiratory distress syndrome or sepsis, and a PaO2 around 12 kPa in patients with cardiac or cerebral ischaemia. Eighty per cent would accept a PaO2 of 8 kPa or lower and 77% would accept a PaO2 of 12 kPa or higher in a clinical trial of oxygenation targets. Conclusion: Intensive care unit doctors preferred PaO2 to SaO2 in monitoring oxygen treatment when peripheral oxygen saturation was not included in the question. The identification of PaO2 as the preferred target and the thorough clarification of preferences are important when ascertaining optimal oxygenation targets. In particular when designing future clinical trials of higher vs lower oxygenation targets in ICU patients.
  •  
317.
  •  
318.
  •  
319.
  • Thomassen, Mads, et al. (författare)
  • Clinical, splicing, and functional analysis to classify BRCA2 exon 3 variants : Application of a points-based ACMG/AMP approach
  • 2022
  • Ingår i: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; 43:12, s. 1921-1944
  • Tidskriftsartikel (refereegranskat)abstract
    • Skipping of BRCA2 exon 3 (∆E3) is a naturally occurring splicing event, complicating clinical classification of variants that may alter ∆E3 expression. This study used multiple evidence types to assess pathogenicity of 85 variants in/near BRCA2 exon 3. Bioinformatically predicted spliceogenic variants underwent mRNA splicing analysis using minigenes and/or patient samples. ∆E3 was measured using quantitative analysis. A mouse embryonic stem cell (mESC) based assay was used to determine the impact of 18 variants on mRNA splicing and protein function. For each variant, population frequency, bioinformatic predictions, clinical data, and existing mRNA splicing and functional results were collated. Variant class was assigned using a gene-specific adaptation of ACMG/AMP guidelines, following a recently proposed points-based system. mRNA and mESC analysis combined identified six variants with transcript and/or functional profiles interpreted as loss of function. Cryptic splice site use for acceptor site variants generated a transcript encoding a shorter protein that retains activity. Overall, 69/85 (81%) variants were classified using the points-based approach. Our analysis shows the value of applying gene-specific ACMG/AMP guidelines using a points-based approach and highlights the consideration of cryptic splice site usage to appropriately assign PVS1 code strength.
  •  
320.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 311-320 av 322
Typ av publikation
tidskriftsartikel (315)
konferensbidrag (3)
forskningsöversikt (1)
bokkapitel (1)
Typ av innehåll
refereegranskat (316)
övrigt vetenskapligt/konstnärligt (4)
Författare/redaktör
Bocci, A. (268)
Li, H. (268)
Wu, X. (268)
Burdin, S. (267)
Clark, A. (267)
Errede, S. (267)
visa fler...
Evans, H. (267)
Fiedler, F. (267)
Fox, H. (267)
Hara, K. (267)
Hou, S. (267)
Huston, J. (267)
Loginov, A. (267)
Nakano, I. (267)
Oh, S. H. (267)
Penning, B. (267)
Thomson, E. (267)
Williams, H. H. (267)
Abbott, B. (266)
Annovi, A. (266)
Boveia, A. (266)
Cerri, A. (266)
Cerrito, L. (266)
D'Onofrio, M. (266)
Giokaris, N. (266)
Gorelov, I. (266)
Hubacek, Z. (266)
Kehoe, R. (266)
Kim, S. H. (266)
Kroll, J. (266)
Kupco, A. (266)
Lipeles, E. (266)
Lokajicek, M. (266)
Mehta, A. (266)
Meyer, J. (266)
Neal, H. A. (266)
Price, D. (266)
Qian, J. (266)
Quadt, A. (266)
Robson, A. (266)
Sawyer, L. (266)
Snyder, S. (266)
Stark, J. (266)
Strauss, M. (266)
Teng, P. K. (266)
Wagner, P. (266)
Wang, S. M. (266)
Watts, G. (266)
Whiteson, D. (266)
Yorita, K. (266)
visa färre...
Lärosäte
Lunds universitet (278)
Uppsala universitet (248)
Stockholms universitet (238)
Kungliga Tekniska Högskolan (233)
Karolinska Institutet (36)
Göteborgs universitet (8)
visa fler...
Linköpings universitet (7)
Umeå universitet (3)
Örebro universitet (3)
Chalmers tekniska högskola (2)
Högskolan Väst (1)
Mälardalens universitet (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (322)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (269)
Medicin och hälsovetenskap (32)
Teknik (1)
Lantbruksvetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy