SwePub
Sök i SwePub databas

  form:Ext_t

Träfflista för sökning "WFRF:(Lander Eric S.) "

form:Search_simp_t: WFRF:(Lander Eric S.)

  • navigation:Result_t 41-42 navigation:of_t 42
hitlist:Modify_result_t
   
hitlist:Enumeration_thitlist:Reference_thitlist:Reference_picture_thitlist:Find_Mark_t
41.
  • Tonomura, Noriko, et al. (creator_code:aut_t)
  • Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
  • 2015
  • record:In_t: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 11:2
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. Golden retrievers in the US show significantly elevated lifetime risk for both B-cell lymphoma (6%) and hemangiosarcoma (20%). We conducted genome-wide association studies for hemangiosarcoma and B-cell lymphoma, identifying two shared predisposing loci. The two associated loci are located on chromosome 5, and together contribute similar to 20% of the risk of developing these cancers. Genome-wide p-values for the top SNP of each locus are 4.6x10(-7) and 2.7x10(-6), respectively. Whole genome resequencing of nine cases and controls followed by genotyping and detailed analysis identified three shared and one B-cell lymphoma specific risk haplotypes within the two loci, but no coding changes were associated with the risk haplotypes. Gene expression analysis of B-cell lymphoma tumors revealed that carrying the risk haplotypes at the first locus is associated with down-regulation of several nearby genes including the proximal gene TRPC6, a transient receptor Ca2+-channel involved in T-cell activation, among other functions. The shared risk haplotype in the second locus overlaps the vesicle transport and release gene STX8. Carrying the shared risk haplotype is associated with gene expression changes of 100 genes enriched for pathways involved in immune cell activation. Thus, the predisposing germ-line mutations in B-cell lymphoma and hemangio-sarcoma appear to be regulatory, and affect pathways involved in T-cell mediated immune response in the tumor. This suggests that the interaction between the immune system and malignant cells plays a common role in the tumorigenesis of these relatively different cancers.
  •  
42.
  •  
Skapa referenser, mejla, bekava och länka
  • navigation:Result_t 41-42 navigation:of_t 42
swepub:Mat_t
swepub:mat_article_t (40)
swepub:mat_researchreview_t (2)
swepub:Level_t
swepub:level_refereed_t (42)
swepub:Hitlist_author_t
Lander, Eric S. (36)
Lindblad-Toh, Kersti ... (28)
Jaffe, David B. (11)
Mauceli, Evan (10)
Gnerre, Sante (9)
Zody, Michael C (9)
deldatabas:search_more_t
Di Palma, Federica (8)
Haussler, David (8)
Johnson, Jeremy (7)
Swofford, Ross (7)
Turner-Maier, Jason (7)
Wilson, Richard K (7)
Clamp, Michele (7)
Chang, Jean L. (7)
Kellis, Manolis (6)
Alfoeldi, Jessica (6)
Lara, Marcia (6)
Ponting, Chris P. (6)
Karlsson, Elinor K. (6)
Miller, Webb (6)
Cuff, James (6)
Xie, Xiaohui (6)
Breen, Matthew (5)
Daly, Mark J. (5)
Mardis, Elaine R (5)
Gibbs, Richard A (5)
Birney, Ewan (5)
Siepel, Adam (5)
Weinstock, George M. (5)
Grabherr, Manfred (4)
Wheeler, David A (4)
Getz, Gad (4)
Heger, Andreas (4)
Aken, Bronwen (4)
Gnirke, Andreas (4)
Haerty, Wilfried (4)
Sharpe, Ted (4)
Muzny, Donna M (4)
Cibulskis, Kristian (4)
Sougnez, Carrie (4)
Collins, Francis S. (4)
Kulbokas, Edward J. (4)
Margulies, Elliott H ... (4)
Green, Eric D. (4)
Kent, W. James (4)
Fulton, Robert (4)
Berlin, Aaron (4)
Garber, Manuel (4)
Mikkelsen, Tarjei S. (4)
Green, Todd (4)
deldatabas:search_less_t
swepub:Hitlist_uni_t
swepub_uni:uu_t (33)
swepub_uni:gu_t (4)
swepub_uni:umu_t (4)
swepub_uni:ki_t (4)
swepub_uni:lu_t (3)
swepub_uni:slu_t (3)
deldatabas:search_more_t
swepub_uni:kth_t (2)
swepub_uni:su_t (2)
swepub_uni:cth_t (1)
swepub_uni:lnu_t (1)
deldatabas:search_less_t
hitlist:Language_t
language:Eng_t (42)
hitlist:HSV_t
hsv:Cat_1_t (15)
hsv:Cat_3_t (15)

hitlist:Year_t

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt tools:Close_t

tools:Permalink_label_t