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Träfflista för sökning "WFRF:(Lewis CM) "

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Numrering	Referens	Omslagsbild	Hitta
61.	Garvert, L, et al. (författare) The association between genetically determined ABO blood types and major depressive disorder 2021 Ingår i: Psychiatry research. - : Elsevier BV. - 1872-7123 .- 0165-1781. ; 299, s. 113837- Tidskriftsartikel (refereegranskat)
62.	Gaspar, HA, et al. (författare) Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017 2018 Ingår i: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 84:6, s. E49-E50 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
63.	Giannakopoulou, O, et al. (författare) The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study 2021 Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 78:11, s. 1258-1269 Tidskriftsartikel (refereegranskat)
64.	Gray, CM, et al. (författare) Impact of chemokine C-C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males 2020 Ingår i: Mucosal immunology. - : Elsevier BV. - 1935-3456 .- 1933-0219. ; 13:1, s. 118-127 Tidskriftsartikel (refereegranskat)
65.	Grotzinger, AD, et al. (författare) Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis 2022 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:5, s. 548- Tidskriftsartikel (refereegranskat)
66.	Hagenaars, SP, et al. (författare) Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression 2020 Ingår i: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. - : Wiley. - 1552-485X. ; 183:6, s. 309-330 Tidskriftsartikel (refereegranskat)
67.	Hanscombe, KB, et al. (författare) Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans 2018 Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 27:21, s. 3813-3824 Tidskriftsartikel (refereegranskat)
68.	Howard, DM, et al. (författare) Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways 2018 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 3578- Tidskriftsartikel (refereegranskat)
69.	Howard, DM, et al. (författare) Genetic stratification of depression in UK Biobank 2020 Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 10:1, s. 163- Tidskriftsartikel (refereegranskat)abstract Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.
70.	Howard, DM, et al. (författare) Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways 2018 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 1470- Tidskriftsartikel (refereegranskat)abstract Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10−8) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in excitatory neurotransmission, mechanosensory behaviour, post synapse, neuron spine and dendrite functions. Our findings suggest that broad depression is the most tractable UK Biobank phenotype for discovering genes and gene sets that further our understanding of the biological pathways underlying depression.

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Resultat 61-70 av 94

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Typ av publikation: tidskriftsartikel (84); konferensbidrag (2); forskningsöversikt (1)

Typ av innehåll: refereegranskat (77); övrigt vetenskapligt/konstnärligt (10)

Författare/redaktör: Lewis, CM (51); Sullivan, PF (38); Breen, G (38); McIntosh, AM (35); Martin, NG (33); Ripke, S (31); visa fler...; Wray, NR (30); Rietschel, M (27); Smoller, JW (27); Levinson, DF (27); Baune, BT (26); Muller-Myhsok, B (26); Byrne, EM (26); Penninx, BWJH (25); Montgomery, GW (25); Lucae, S (25); Hamilton, SP (24); Mors, O (24); Potash, JB (24); Mattheisen, M (23); Cichon, S (23); Grabe, HJ (23); Nothen, MM (23); Adams, MJ (23); Schulze, TG (23); Metspalu, A (23); Gill, M. (23); Clarke, TK (23); Gordon, SD (23); Boomsma, DI (22); Milaneschi, Y (22); Perlis, RH (22); Strohmaier, J (22); MacIntyre, DJ (22); Owen, MJ (22); Hottenga, JJ (21); Craddock, N (21); Werge, T (21); Hoffmann, P (21); Deary, IJ (21); Medland, SE (21); Degenhardt, F (21); Shi, JX (21); Esko, T (21); Stefansson, K (21); Herms, S. (21); Kendler, KS (21); O'Donovan, MC (21); McGuffin, P (21); Weissman, MM (21); visa färre...

Lärosäte: Karolinska Institutet (90); Lunds universitet (12); Göteborgs universitet (9); Umeå universitet (9); Uppsala universitet (5); Stockholms universitet (3); visa fler...; Örebro universitet (2); Linköpings universitet (2); Kungliga Tekniska Högskolan (1); Högskolan Dalarna (1); Sveriges Lantbruksuniversitet (1); visa färre...

Språk: Engelska (94)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (30); Naturvetenskap (4); Samhällsvetenskap (1)

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