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Sökning: WFRF:(Lim J)

  • Resultat 921-930 av 1038
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921.
  • Lim, J. A., et al. (författare)
  • Unexpected phase locking of magnetic fluctuations in the multi-k magnet USb
  • 2013
  • Ingår i: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 87:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The spin waves in the multi-k antiferromagnet USb soften and become quasielastic well below the antiferromagnetic ordering temperature T-N. This occurs without a magnetic or structural transition. It has been suggested that this change is in fact due to dephasing of the different multi-k components: a switch from 3-k to 1-k behavior. In this work, we use inelastic neutron scattering with tridirectional polarization analysis to probe the quasielastic magnetic excitations and reveal that the 3-k structure does not dephase. More surprisingly, the paramagnetic correlations also maintain the same clear phase correlations well above T-N ( up to at least 1.4T(N)). DOI: 10.1103/PhysRevB.87.064421
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922.
  • Lim, Jeremy J., et al. (författare)
  • A phase 2 randomized, double-blind, placebo-controlled trial of MHAA4549A, a monoclonal antibody, plus oseltamivir in patients hospitalized with severe influenza a virus infection
  • 2020
  • Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804. ; 64:7
  • Tidskriftsartikel (refereegranskat)abstract
    • For patients hospitalized with severe influenza A virus infection, morbidity and mortality remain high. MHAA4549A, a human monoclonal antibody targeting the influenza A virus hemagglutinin stalk, has demonstrated pharmacological activity in animal studies and in a human influenza A challenge study. We evaluated the safety and efficacy of MHAA4549A plus oseltamivir against influenza A virus infection in hospitalized patients. The CRANE trial was a phase 2b randomized, double-blind, placebo-controlled study of single intravenous (i.v.) doses of placebo, 3,600 mg MHAA4549A, or 8,400 mg MHAA4549A each combined with oral oseltamivir (+OTV) in patients hospitalized with severe influenza A virus infection. Patients, enrolled across 68 clinical sites in 18 countries, were randomized 1:1:1. The primary outcome was the median time to normalization of respiratory function, defined as the time to removal of supplemental oxygen support to maintain a stable oxygen saturation (SpO2) of ≥95%. Safety, pharmacokinetics, and effects on influenza viral load were also assessed. One hundred sixty-six patients were randomized and analyzed during a preplanned interim analysis. Compared to placebo+OTV, MHAA4549A+OTV did not significantly reduce the time to normalization of respiratory function (placebo+OTV, 4.28 days; 3,600 mg MHAA4549A+OTV, 2.78 days; 8,400 mg MHAA4549A+OTV, 2.65 days), nor did it improve other secondary clinical outcomes. Adverse event frequency was balanced across cohorts. MHAA4549A+OTV did not further reduce viral load versus placebo+OTV. In hospitalized patients with influenza A virus infection, MHAA4549A did not improve clinical outcomes over OTV alone. Variability in patient removal from oxygen supplementation limited the utility of the primary endpoint. Validated endpoints are needed to assess novel treatments for severe influenza A virus infection. (This study has been registered at ClinicalTrials.gov under registration no. NCT02293863.).
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923.
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925.
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926.
  • Lim, Kathleen, et al. (författare)
  • Oxygen Saturation Targeting in Preterm Infants Receiving Continuous Positive Airway Pressure
  • 2014
  • Ingår i: The Journal of Pediatrics. - : Elsevier. - 0022-3476 .- 1097-6833. ; 164:4, s. 730-736
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective The precision of oxygen saturation (SpO(2)) targeting in preterm infants on continuous positive airway pressure (CPAP) is incompletely characterized. We therefore evaluated SpO(2) targeting in infants solely receiving CPAP, aiming to describe their SpO(2) profile, to document the frequency of prolonged hyperoxia and hypoxia episodes and of fraction of inspired oxygen (FiO(2)) adjustments, and to explore the relationships with neonatal intensive care unit operational factors. Study design Preterm infants less than37 weeks gestation in 2 neonatal intensive care units were studied if they were receiving CPAP and in supplemental oxygen at the beginning of each 24-hour recording. SpO(2), heart rate, and FiO(2) were recorded (sampling interval 1-2 seconds). We measured the proportion of time spent in predefined SpO(2) ranges, the frequency of prolonged episodes (greater than= 30 seconds) of SpO(2) deviation, and the effect of operational factors including nurse-patient ratio. Results A total of 4034 usable hours of data were recorded from 45 infants of gestation 30 (27-32) weeks (median [IQR]). When requiring supplemental oxygen, infants were in the target SpO(2) range (88%-92%) for only 31% (19%-39%) of total recording time, with 48 (6.9-90) episodes per 24 hours of severe hyperoxia (SpO(2) greater than= 98%), and 9.0 (1.6-21) episodes per 24 hours of hypoxia (SpO(2) less than80%). An increased frequency of prolonged hyperoxia in supplemental oxygen was noted when nurses were each caring for more patients. Adjustments to FiO(2) were made 25 (16-41) times per day. Conclusion SpO(2) targeting is challenging in preterm infants receiving CPAP support, with a high proportion of time spent outside the target range and frequent prolonged hypoxic and hyperoxic episodes.
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927.
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928.
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929.
  • Lim, Michelle, et al. (författare)
  • Early-career experts essential for planetary sustainability
  • 2017
  • Ingår i: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 29, s. 151-157
  • Forskningsöversikt (refereegranskat)abstract
    • Early-career experts can play a fundamental role in achieving planetary sustainability by bridging generational divides and developing novel solutions to complex problems. We argue that intergenerational partnerships and interdisciplinary collaboration among early-career experts will enable emerging sustainability leaders to contribute fully to a sustainable future. We review 16 international, interdisciplinary, and sustainability-focused early-career capacity building programs. We conclude that such programs are vital to developing sustainability leaders of the future and that decision-making for sustainability is likely to be best served by strong institutional cultures that promote intergenerational learning and involvement.
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930.
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