| 81. |
- Nilsson, Sara, 1990-
(författare)
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How requirements development could support design of effective and resource-efficient offerings
- 2017
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- What a company offers its customers has to fulfil several different needs, desires, constraints, which can originate from multiple different sources that affect the offering throughout its life cycle. All these criteria have to come together and be translated into statements that can support the designer’s understanding of the offering’s purpose. This translation is done through a requirements development process to provide a controlled process to define statements that describe what the offering is supposed to fulfil.This research provides insights on key challenges and success factors in requirements development to support the design of effective and resource-efficient offerings. Namely, it identifies crucial sources and aspects to be considered, and a requirements development process demonstrating how to overcome identified challenges. By getting the requirements right from the beginning, sub-optimisation and unnecessary time and risks can be avoided. The consideration of accurate sources and aspects is considered to be one of the most important factors for the successful design of offerings. It is also in the earliest phases of design, that is to say requirements development, where one has the greatest possibility to affect the environmental impact of the offering. What is missing, however, is sufficient and appropriate support in industry on how to do so.The gap between the three areas of effectiveness and resource efficiency, design of integrated offerings, and requirements development has been investigated. Results are based on findings in the literature and in industry, identified primarily by qualitative studies. In the research, 15 different companies have been included through a number of interviews and discussions.Key sources and aspects to consider in the requirements development process are identified along with challenges, and success factors that can be utilised to overcome the identified challenges. This research’s final results include an adapted requirements development process that considers the earlier-mentioned sources and aspect, challenges, and success factors. Such a requirements development process should support the design of effective and resource-efficient offerings.
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| 82. |
- Nordström, Anna, et al.
(författare)
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Cognitive function and other risk factors for mild traumatic brain injury in young men : nationwide cohort study
- 2013
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Ingår i: The BMJ. - : BMJ Publishing Group. - 1756-1833. ; 346, s. f723-
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Tidskriftsartikel (refereegranskat)abstract
- Objective To investigate cognitive function and other risk factors for mild traumatic brain injury in young men.Design Nationwide prospective cohort study.Setting Sweden.Participants 305 885 men conscripted for military service from 1989 to 1994.Main outcome measure mild traumatic brain injuries in relation to cognitive function and other potential risk factors assessed at conscription and follow-up.Results Men with one mild traumatic brain injury within two years before (n=1988) or after cognitive testing (n=2214) had about 5.5% lower overall cognitive function scores than did men with no mild traumatic brain injury during follow up (P<0.001 for both). Moreover, men with at least two mild traumatic brain injuries after cognitive testing (n=795) had 15% lower overall cognitive function scores compared with those with no such injury (P<0.001). Independent strong risk factors (P<1x10(-10)) for at least one mild traumatic brain injury after cognitive testing (n=12 494 events) included low overall cognitive function, a previous mild traumatic brain injury, hospital admission for intoxications, and low education and socioeconomic status. In a sub-cohort of twin pairs in which one twin had a mild traumatic brain injury before cognitive testing (n=63), both twins had lower logical performance and technical performance compared with men in the total cohort with no mild traumatic brain injury (P<0.05 for all).Conclusion Low cognitive function, intoxications, and factors related to low socioeconomic status were strong independent risk factors for mild traumatic brain injuries in men. The low cognitive function in twin pairs discordant for mild traumatic brain injury suggests a genetic component to the low cognitive function associated with such injuries. The study included only men, so inferences to women should be made with caution.
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| 83. |
- Olofsson, Jonas K., et al.
(författare)
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Smell-based memory training : Evidence of olfactory learning andtransfer to a visual task
- 2024
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In cognitive training interventions, engaging in visual processing tasks rarely stimulate transfer of learning to untrained tasks. Human and animal research suggests that the sense of smell, olfaction, are intimately associated with visual-spatial orientation and memory encoding networks. In this study, we investigated if olfactory enhancement would facilitate visuo-spatial learning. We devised an odor memory intervention to investigate “asymmetric” transfer effects such that odor-based memory training would transfer to a visual-based memory gain, but not vice versa. Participants were randomly assigned to daily memory training for 40 days with either the odor task or a visual control task with a similar difficulty level. Results showed that while visual training did not produce transfer, olfactory training produced transfer to the untrained visual memory task. Furthermore, odor training uniquely improved participants’ performance on odor discrimination and naming tasks to achieve the performance level of wine experts. Our results indicate that the olfactory system is highly responsive to training, and the sense of smell might be a promising vehicle to achieve perceptual and cognitive enhancement.
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| 84. |
- Olofsson, Jonas K., et al.
(författare)
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Smell-Based Memory Training : Evidence of Olfactory Learning and Transfer to the Visual Domain
- 2020
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Ingår i: Chemical Senses. - : Oxford University Press (OUP). - 0379-864X .- 1464-3553. ; 45:7, s. 593-600
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Tidskriftsartikel (refereegranskat)abstract
- Human and non-human animal research converge to suggest that the sense of smell, olfaction, has a high level of plasticity and is intimately associated with visual-spatial orientation and memory encoding networks. We investigated whether olfactory memory (OM) training would lead to transfer to an untrained visual memory (VM) task, as well as untrained olfactory tasks. We devised a memory intervention to compare transfer effects generated by olfactory and non-olfactory (visual) memory training. Adult participants were randomly assigned to daily memory training for about 40 days with either olfactory or visual tasks that had a similar difficulty level. Results showed that while visual training did not produce transfer to the OM task, olfactory training produced transfer to the untrained VM task. Olfactory training also improved participants’ performance on odor discrimination and naming tasks, such that they reached the same performance level as a high-performing group of wine professionals. Our results indicate that the olfactory system is highly responsive to training, and we speculate that the sense of smell may facilitate transfer of learning to other sensory domains. Further research is however needed in order to replicate and extend our findings.
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| 85. |
- Olsson, Mats, et al.
(författare)
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The UGT2B17 gene deletion is not associated with prostate cancer risk
- 2008
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Ingår i: The Prostate. - : Wiley-Blackwell. - 0270-4137 .- 1097-0045. ; 68:5, s. 571-575
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Deletion polymorphism of the UDP-glucuronosyltransferase 2B17 (UGT2B17) gene has been associated with an increased prostate cancer risk in two previous independent studies. Here we determine the risk in a large-scale population-based case-control study.METHODS: Genotyping was conducted with a 5'-nuclease activity assay to distinguish those with one or two UGT2B17 gene copies (ins/del and ins/ins) from individuals homozygous for the deletion (del/del) allele.RESULTS: In contrast to previous findings, no association between the UGT2B17 deletion polymorphism and prostate cancer risk was found. Furthermore the UGT2B17 gene deletion did not affect the risk for prostate cancer specific death.CONCLUSION: The UGT2B17 deletion polymorphism does not play a major role in prostate cancer susceptibility as previously indicated.
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| 86. |
- Olsson, Sara K., et al.
(författare)
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Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder
- 2010
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Ingår i: Journal of Psychiatry & Neuroscience. - : CMA Joule Inc.. - 1180-4882 .- 1488-2434. ; 35:3, s. 195-199
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Tidskriftsartikel (refereegranskat)abstract
- Background: Patients with schizophrenia show elevated brain levels of the neuroactive tryptophan metabolite kynurenic acid (KYNA) This astrocyte] derived mediator acts as a neuroprotectant and modulates sensory gating and cognitive functiona We measured the levels of KYNA in the cerebrospinal fluid T vSyU of patients with bipolar disorder and healthy volunteers to investigate the putative involvement of KYNA in bipolar disorder. Methods: We obtained CSF by lumbar puncture from 23 healthy men and 31 euthymic men with bipolar disorder. We analyzed the samples using high] performance liquid chromatography. Results: Patients with bipolar disorder had increased levels of KYNA in their CSF compared with healthy volunteers (1.71 nM, standard error of the mean [SEM] cad, va dad, nM, SEM cacln p = 0.002. The levels of KYNA were positively correlated with age among bipolar patients but not healthy volunteersa Limitations: The influence of ongoing drug treatment among patients cannot be ruled outa We conducted our study during the euthymic phase of the diseasea Conclusion: Brain KYNA levels are increased in euthymic men with bipolar disorder. In addition, KYNA levels increased with age in these patientsa These findings indicate shared mechanisms between bipolar disorder and schizophrenia. Elevated levels of brain KYNA may provide further insight to the pathophysiology and progression of bipolar disorder.
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| 87. |
- Palmqvist Öberg, Nina Margareta, et al.
(författare)
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Last general practitioner consultation during the final month of life : a national medical record review of suicides in Sweden
- 2024
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Ingår i: BMC Primary Care. - : BioMed Central (BMC). - 2731-4553. ; 25:1
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Individuals who die by suicide often consult their general practitioners (GPs) in their final weeks of life. The aim of this study was to gain a deeper knowledge of the clinical characteristics and GP assessments and treatments among individuals who consulted their GPs during the month preceding suicide. Further, we compared these features in those with and without contact with psychiatric services (PC and NPC, respectively) during the two years that preceded the suicide.Design: A nationwide retrospective explorative study investigating medical records.Setting: Primary care in Sweden.Participants: Individuals who died by suicide in Sweden in 2015 with a GP visit within 30 days of death.Results: The study cohort corresponds to one fifth (n = 238) of all suicides that occurred in Sweden in 2015 (n = 1179), representing all those with available primary care records showing contact with a GP during the final 30 days of life (NPC: n = 125; PC: n = 113). The mean age was 58 years +/- 19. Patients in the NPC group were older (NPC: 63 years +/- 19 vs. PC: 53 years +/- 18, p < 0.0001) and presented psychiatric symptoms less often (NPC: 50% vs. PC: 67%, p < 0.006). Somatic symptoms were as common as psychiatric symptoms for the whole sample, being present in more than half of individuals. Suicide risk was noted in only 6% of all individuals. Referral to psychiatric services occurred in 14%, less commonly for the NPC group (NPC: 6% vs. PC: 22%, p < 0.001). Cardiovascular or respiratory symptoms were noted in 19%, more often in the NPC group (NPC: 30% vs. PC: 6%, p < 0.001), as were diagnoses involving the circulatory system (all 10%, NPC:14% vs. PC: 5%, p < 0.020).Conclusion: A high level of somatic symptoms was observed in primary care patients both with and without psychiatric contact, and this might have influenced GPs' management decisions. Psychiatric symptoms were noted in two thirds of those with psychiatric contact but only half of those without. While GPs noted psychiatric symptoms in over half of all individuals included in the study, they seldom noted suicide risk. These findings highlight the need for increased attention to psychiatric symptoms and suicide risk assessment, particularly among middle-aged and older individuals presenting with somatic symptoms.Strengths and limitations of this study: The National Cause of Death Register has excellent coverage of suicide deaths and access to medical records was very good. The medical record review provided detailed information regarding primary care utilization before death by suicide. Because of the lack of statistical power, due to the limited number of persons with GP contact during the last month of life, we chose not to correct for multiple comparisons. Our study approach did not capture the reasons behind GPs' documentation of elevated suicide risk. No systematic inter-rater reliability (IRR) testing was made, however, reviewers received training and continuous support from the research group.
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| 88. |
- Persson, Erik, et al.
(författare)
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Some challenges in connection with the construction of a Massive Open Online Course on ethical and societal aspects of AI
- 2021
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Ingår i: Hållbart lärarskap : universitetsundervisning i förändring – Proceedings från Humanistiska och Teologiska fakulteternas pedagogiska inspirationskonferens 2020 - universitetsundervisning i förändring – Proceedings från Humanistiska och Teologiska fakulteternas pedagogiska inspirationskonferens 2020. - 9789172674530 - 9789172674547 ; , s. 99-110
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Konferensbidrag (refereegranskat)abstract
- The Swedish government is at present investing heavily in making Sweden competitive in AI (Artificial Intelligence). As a part of that effort, Lund University has been commissioned with providing a series of MOOCs (Massive Open Online Courses) on different topics regarding AI, including several topics dealing with Humans and AI. As a comprehensive university, Lund University has an advantage in being able to facilitate collaboration across academic fields to meet multidisciplinary knowledge needs in the wider society for the future of sustainable AI design, implementation, and use. The courses aim at a very wide audience but are particularly suited for those who did not major in AI related subjects at the university but who nonetheless have to deal with AI in their work. This resulted in a suite of courses of which one deals with societal challenges and ethical issues in AI. The course covers algorithmic bias, surveillance, democracy, responsibility, how to maintain control of intelligent machines, and conceptual issues regarding machine intelligence. In this chapter we present some challenges in connection with the making of this course, and how these challenges were overcome.
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| 89. |
- Peter, Hannes, et al.
(författare)
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Function-specific response to depletion of microbial diversity
- 2011
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Ingår i: The ISME Journal. - : Springer Science and Business Media LLC. - 1751-7362 .- 1751-7370. ; 5:2, s. 351-361
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Tidskriftsartikel (refereegranskat)abstract
- Recent meta-analyses suggest that ecosystem functioning increases with biodiversity, but contradictory results have been presented for some microbial functions. Moreover, observations of only one function underestimate the functional role of diversity because of species-specific trade-offs in the ability to carry out different functions. We examined multiple functions in batch cultures of natural freshwater bacterial communities with different richness, achieved by a dilution-to-extinction approach. Community composition was assessed by molecular fingerprinting of 16S rRNA and chitinase genes, representing the total community and a trait characteristic for a functional group, respectively. Richness was positively related to abundance and biomass, negatively correlated to cell volumes and unrelated to maximum intrinsic growth rate. The response of chitin and cellulose degradation rates depended on the presence of a single phylotype. We suggest that species identity and community composition rather than richness matters for specific microbial processes.
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| 90. |
- Probert-Lindström, Sara, et al.
(författare)
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An examination of distress tolerance, anxiety sensitivity, and intolerance of uncertainty in adults in routine psychiatric care
- 2023
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Ingår i: Acta Psychologica. - : Elsevier BV. - 1873-6297 .- 0001-6918. ; 235, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- AimA person's ability to tolerate negative emotional states (Distress Tolerance - DT), uncertainty in their everyday lives (Intolerance of Uncertainty - IU), and a tendency to appraise their own feelings of anxiety as harmful (Anxiety Sensitivity - AS) have all been identified as vulnerability factors for anxiety and depressive disorders. However, the relationship between these variables and broader aspects of psychiatric symptom severity in participants recruited from routine care remains unclear.MethodThe Distress Tolerance Scale (DTS), Anxiety Sensitivity Scale-3 (ASI-3), and Intolerance of Uncertainty Scale-Short Form (IUS-12) were administered to 91 patients receiving treatment at the Lund Outpatient Psychiatric Clinic. Data was collected from their medical records about their psychiatric history and scores on the Brief Symptom Inventory (BSI). The relationship between total scores on the DTS, ASI-3, IUS-12 and BSI were evaluated via correlations and regression analyses.ResultsDTS, ASI-3, and IUS-12 total scores correlated in the moderate to large range, and consistent with previous literature, were moderately to strongly correlated with the severity of self-reported depression, anxiety and overall symptoms (BSI). Regression analyses indicated that together, scores on the DTS, ASI-3 and IUS-12 explained moderate levels of variance in BSI symptom scores, with DTS scores showing the strongest associations. These findings suggest that further studies are needed to examine the construct and criterion validity of the three scales. Further validation of these Swedish-language are also warranted.
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