| 131. |
- Orozco, Gisela, et al.
(författare)
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Study of functional variants of the BANK1 gene in rheumatoid arthritis
- 2009
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 60:2, s. 372-379
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate 1 functional (rs17266594) and 2 potentially functional (rs10516487 and rs3733197) BANK1 variants, which were previously identified as systemic lupus erythematosus (SLE) susceptibility markers, to test whether they are associated with rheumatoid arthritis (RA). METHODS: Four different cohorts were included in the study: 1,080 RA patients and 1,368 healthy controls from Spain, 278 RA patients and 568 healthy controls from Sweden, 288 RA patients and 287 healthy controls from Argentina, and 288 RA patients and 288 healthy controls from Mexico. Samples were genotyped for BANK1 single-nucleotide polymorphisms (SNPs) using a TaqMan 5'-allele discrimination assay. Statistical analysis comparing allele and genotype distributions was performed with the chi-square test. RESULTS: We did not find a significant association between RA and the rs10516487 and rs17266594 BANK1 polymorphisms. However, there was an increase in the major alleles among RA patients. Similarly, for rs3733197, there was an increase in the major allele among patients in every cohort. Nevertheless, this skewing reached statistical significance in the Spanish (P = 0.01, odds ratio [OR] 1.17 [95% confidence interval (95% CI) 1.03-1.32]) and Argentinean (P = 0.04, OR 1.31 [95% CI 1.00-1.72]) populations. We found a significant association of rs10516487 (P = 0.005, OR 1.15 [95% CI 1.04-1.28]) and rs3733197 (P = 0.0009, OR 1.17 [95% CI 1.07-1.29]) with RA in the pooled analysis. In a 3-SNP haplotype analysis, we found that the major TGG haplotype was significantly associated with RA (P = 0.005, OR 1.14 [95% CI 1.04-1.25]). In addition, we found a common CAA haplotype that was protective against RA (P = 0.0004, OR 0.82 [95% CI 0.74-0.92]). CONCLUSION: These results suggest that BANK1 SNPs and haplotypes may contribute to RA susceptibility with a low risk.
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| 132. |
- Padilla-Morales, Benjamin, et al.
(författare)
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Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- In mammals, sexual size dimorphism often reflects the intensity of sexual selection, yet its connection to genomic evolution remains unexplored. Gene family size evolution can reflect shifts in the relative importance of different molecular functions. Here, we investigate the associate between brain development gene repertoire to sexual size dimorphism using 124 mammalian species. We reveal significant changes in gene family size associations with sexual size dimorphism. High levels of dimorphism correlate with an expansion of gene families enriched in olfactory sensory perception and a contraction of gene families associated with brain development functions, many of which exhibited particularly high expression in the human adult brain. These findings suggest a relationship between intense sexual selection and alterations in gene family size. These insights illustrate the complex interplay between sexual dimorphism, gene family size evolution, and their roles in mammalian brain development and function, offering a valuable understanding of mammalian genome evolution.
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| 133. |
- Pandolfi, Marco, et al.
(författare)
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A European aerosol phenomenology-6 : scattering properties of atmospheric aerosol particles from 28 ACTRIS sites
- 2018
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 18:11, s. 7877-7911
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the light-scattering properties of atmospheric aerosol particles measured over the past decade at 28 ACTRIS observatories, which are located mainly in Europe. The data include particle light scattering (sigma(sp)) and hemispheric backscattering (sigma(bsp)) coefficients, scattering Angstrom exponent (SAE), backscatter fraction (BF) and asymmetry parameter (g). An increasing gradient of sigma(sp) is observed when moving from remote environments (arctic/mountain) to regional and to urban environments. At a regional level in Europe, sigma(sp) also increases when moving from Nordic and Baltic countries and from western Europe to central/eastern Europe, whereas no clear spatial gradient is observed for other station environments. The SAE does not show a clear gradient as a function of the placement of the station. However, a west-to-east-increasing gradient is observed for both regional and mountain placements, suggesting a lower fraction of fine-mode particle in western/south-western Europe compared to central and eastern Europe, where the fine-mode particles dominate the scattering. The g does not show any clear gradient by station placement or geographical location reflecting the complex relationship of this parameter with the physical properties of the aerosol particles. Both the station placement and the geographical location are important factors affecting the intraannual variability. At mountain sites, higher sigma(sp) and SAE values are measured in the summer due to the enhanced boundary layer influence and/or new particle-formation episodes. Conversely, the lower horizontal and vertical dispersion during winter leads to higher sigma(sp) values at all low-altitude sites in central and eastern Europe compared to summer. These sites also show SAE maxima in the summer (with corresponding g minima). At all sites, both SAE and g show a strong variation with aerosol particle loading. The lowest values of g are always observed together with low sigma(sp) values, indicating a larger contribution from particles in the smaller accumulation mode. During periods of high sigma(sp) values, the variation of g is less pronounced, whereas the SAE increases or decreases, suggesting changes mostly in the coarse aerosol particle mode rather than in the fine mode. Statistically significant decreasing trends of sigma(sp) are observed at 5 out of the 13 stations included in the trend analyses. The total reductions of sigma(sp) are consistent with those reported for PM2.5 and PM10 mass concentrations over similar periods across Europe.
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| 134. |
- Picetti, Edoardo, et al.
(författare)
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Early management of adult traumatic spinal cord injury in patients with polytrauma : a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)
- 2024
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Ingår i: World Journal of Emergency Surgery. - : BioMed Central (BMC). - 1749-7922. ; 19
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Tidskriftsartikel (refereegranskat)abstract
- Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies.Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted.Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak).Conclusions: This consensus provides practical recommendations to support a clinician's decision making in the management of tSCI polytrauma patients.
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| 135. |
- Ramstad, Robin, 1986-, et al.
(författare)
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Phobos 2/ASPERA data revisited : Planetary ion escape rate from Mars near the 1989 solar maximum
- 2013
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 40:3, s. 477-481
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Tidskriftsartikel (refereegranskat)abstract
- 1] Insights about the near-Mars space environment from Mars Express observations have motivated a revisit of the Phobos 2/ASPERA ion data from 1989. We have expanded the analysis to now include all usable heavy ion (O+, O, CO) measurements from the circular orbits of Phobos 2. Phobos 2/ASPERA ion fluxes in the Martian tail are compared with previous results obtained by the instruments on Phobos 2. Further validation of the measurement results is obtained by comparing IMP-8 and Phobos 2/ASPERA solar wind ion fluxes, taking into account the time lag between Earth and Mars. Heavy ion flux measurements from 18 circular equatorial orbits around Mars are bin-averaged to a grid, using the MSE (electric field) frame of reference. The binned data are subsequently integrated to determine the total escape rate of planetary ions. From this we derive a total planetary heavy ion escape rate of (2–3) × 1025 s−1 from Mars for the 1989 solar maximum
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| 136. |
- Richards, Stephen, et al.
(författare)
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The genome of the model beetle and pest Tribolium castaneum.
- 2008
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Ingår i: Nature. - 1476-4687. ; 452:7190, s. 949-55
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Tidskriftsartikel (refereegranskat)abstract
- Tribolium castaneum is a representative of earth’s most numerous eukaryotic order, a powerful model organism for the study of generalized insect development, and also an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved an ability to interact with a diverse chemical environment as evidenced by large expansions in odorant and gustatory receptors, as well as p450 and other detoxification enzymes. Developmental patterns in Tribolium are more representative of other arthropods than those found in Drosophila, a fact represented in gene content and function. For one, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, and some are expressed in the growth zone crucial for axial elongation in short germ development. Systemic RNAi in T. castaneum appears to use mechanisms distinct from those found in C. elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
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| 137. |
- Rico, Sergio, et al.
(författare)
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A case study of industry–academia communication in a joint software engineering research project
- 2021
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Ingår i: Journal of software: Evolution and Process. - : Wiley. - 2047-7481 .- 2047-7473.
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Tidskriftsartikel (refereegranskat)abstract
- Empirical software engineering research relies on good communication with industrial partners. Conducting joint research both requires and contributes to bridging the communication gap between industry and academia (IA) in software engineering. This study aims to explore communication between the two parties in such a setting. To better understand what facilitates good IA communication and what project outcomes such communication promotes, we performed a case study, in the context of a long-term IA joint project, followed by a validating survey among practitioners and researchers with experience of working in similar settings. We identified five facilitators of IA communication and nine project outcomes related to this communication. The facilitators concern the relevance of the research, practitioners' attitude and involvement in research, frequency of communication and longevity of the collaboration. The project outcomes promoted by this communication include, for researchers, changes in teaching and new scientific venues, and for practitioners, increased awareness, changes to practice, and new tools and source code. Besides, both parties gain new knowledge and develop social-networks through IA communication. Our study presents empirically based insights that can provide advise on how to improve communication in IA research projects and thus the co-creation of software engineering knowledge that is anchored in both practice and research.
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| 138. |
- Rico, Sergio, et al.
(författare)
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A taxonomy for improving industry-academia communication in IoT vulnerability management
- 2019
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Ingår i: 2019 45th Euromicro Conference on Software Engineering and Advanced Applications (SEAA). - 9781728134222 - 9781728134215 ; , s. 38-45
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Konferensbidrag (refereegranskat)abstract
- Background: In software engineering, industry-academia is a symbiotic relationship. Researchers need to be aware of the industry to produce relevant research, while practitioners are educated in academia and could take advantage of empirical research. The SERP taxonomy architecture is designed to support communication between practitioners and researchers in software engineering. Objective: The purpose of this study is to analyze to what extent the SERP taxonomy architecture is useful for improving communication between researchers and practitioners in IoT vulnerability management. Method: We developed a SERP taxonomy for IoT vulerability management, SERP-MENTION, in an incremental way. Along the development, we evaluated the developed taxonomy in a project of industry academia collaboration. Results: In addition to the taxonomy itself we elaborate on the taxonomy development process and the potential of SERP-MENTION to support communication between researchers and practitioners within the area.Conclusion: The SERP architecture can be used in a new field, it is perceived as useful by potential users to better describe and communicate research outputs and practical challenges in software vulnerability management.
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| 139. |
- Rico, Sergio, et al.
(författare)
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Experiences from conducting rapid reviews in collaboration with practitioners — Two industrial cases
- 2024
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Ingår i: Information and Software Technology. - : Elsevier. - 0950-5849 .- 1873-6025. ; 167
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Tidskriftsartikel (refereegranskat)abstract
- Context: Evidence-based software engineering (EBSE) aims to improve research utilization in practice. It relies on systematic methods to identify, appraise, and synthesize existing research findings to answer questions of interest for practice. However, the lack of practitioners’ involvement in these studies’ design, execution, and reporting indicates a lack of appreciation for the need for knowledge exchange between researchers and practitioners. The resultant systematic literature studies often lack relevance for practice. Objective: This paper explores the use of Rapid Reviews (RRs), in fostering knowledge exchange between academia and industry. Through the lens of two case studies, we delve into the practical application and experience of conducting RRs. Methods: We analyzed the conduct of two rapid reviews by two different groups of researchers and practitioners. We collected data through interviews, and the documents produced during the review (like review protocols, search results, and presentations). The interviews were analyzed using thematic analysis. Results: We report how the two groups of researchers and practitioners performed the rapid reviews. We observed some benefits, like promoting dialogue and paving the way for future collaborations. We also found that practitioners entrusted the researchers to develop and follow a rigorous approach and were more interested in the applicability of the findings in their context. The problems investigated in these two cases were relevant but not the most immediate ones. Therefore, rapidness was not a priority for the practitioners. Conclusion: The study illustrates that rapid reviews can support researcher-practitioner communication and industry-academia collaboration. Furthermore, the recommendations based on the experiences from the two cases complement the detailed guidelines researchers and practitioners may follow to increase interaction and knowledge exchange. © 2023 The Author(s)
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| 140. |
- Rico, Sergio, et al.
(författare)
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Guidelines for conducting interactive rapid reviews in software engineering -- from a focus on technology transfer to knowledge exchange
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Evidence-based software engineering (EBSE) aims to improve research utilization in practice. It relies on systematic methods (like systematic literature reviews, systematic mapping studies, and rapid reviews) to identify, appraise, and synthesize existing research findings to answer questions of interest. However, the lack of practitioners' involvement in the design, execution, and reporting of these methods indicates a lack of appreciation for knowledge exchange between researchers and practitioners. Within EBSE, the main reason for conducting these systematic studies is to answer the practitioner's questions and impact practice. However, in many cases, academics have undertaken these studies without any direct involvement of practitioners.This report focuses on the rapid review guidelines and presents practical advice on conducting these with practitioner involvement to facilitate knowledge co-creation.Based on a literature review of rapid reviews and stakeholders engagement in medicine and our experience of using secondary studies in software engineering, we propose extensions to an existing proposal for rapid reviews in software engineering to increase researchers-practitioners knowledge exchange. We refer to the extended method as an interactive rapid review.An interactive rapid review is a streamlined approach to conduct agile literature reviews in close collaboration between researchers and practitioners in software engineering. This report describes the process and discusses possible usage scenarios and some reflections from the proposal's ongoing evaluation.The proposed guidelines will potentially boost knowledge co-creation through active researcher-practitioner interaction by streamlining practitioners' involvement and recognizing the need for an agile process.
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