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Sökning: WFRF:(Mazur J) > (2005-2009)

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11.
  • Laane, E., et al. (författare)
  • Dendritic cell regeneration in the bone marrow of children treated for acute lymphoblastic leukaemia
  • 2007
  • Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 66:5, s. 572-583
  • Tidskriftsartikel (refereegranskat)abstract
    • Dendritic cells (DC) play a pivotal role in coordinating functions of the immune system. Little is known about DC levels in the bone marrow (BM) of patients receiving cytostatic treatment. We investigated DC levels by flow cytometry in BM at diagnosis, during and post-treatment in 76 children with acute lymphoblastic leukaemia (ALL). The levels of both plasmacytoid DC (pDC) and myeloid DC (mDC) were profoundly reduced at diagnosis. However, the levels of pDC and mDC were significantly higher in T-precursor ALL patients when compared with B-precursor ALL patient group (P = 0.044 and 0.041 respectively). Both subsets normalized in both standard-risk (SR) and high-risk patients after the end of induction at day 50. Patients with minimal residual disease (MRD) at day 50 had significantly higher pDC levels than MRD-negative patients (P = 0.021). In B-precursor SR ALL patients, mDC levels but not pDC levels decreased during prolonged maintenance treatment, remaining reduced at the end of treatment (P = 0.032) and at 6 months post-treatment (P = 0.028). In conclusion, levels of DC in BM normalize quickly in children treated for ALL. Long-term treatment may more profoundly affect mDC subset, which shows reduced levels several months after treatment.
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14.
  • Mazur, S., et al. (författare)
  • A strike-slip terrane boundary in Wedel Jarlsberg Land, Svalbard, and its bearing on correlations of SW Spitsbergen with the Pearya terrane and Timanide belt
  • 2009
  • Ingår i: Journal of the Geological Society. - : Geological Society of London. - 0016-7649 .- 2041-479X. ; 166:Part 3, s. 529-544
  • Tidskriftsartikel (refereegranskat)abstract
    • Southwest Spitsbergen, Wedel Jarlsberg Land consists of two Proterozoic terranes with differing structural and metamorphic histories. The northern terrane experienced two Early Palaeozoic deformation events both accompanied by greenschist-facies metamorphism of similar grade. The southern terrane records a Neoproterozoic pervasive amphibolite-facies metamorphism and strong deformational fabric only locally retrogressed during a Caledonian greenschist-grade event. The terranes are seperated by an important sinistral ductile shear zone defined as the Vimsodden Kosibapasset zone, which comprises wrench- and contraction-dominated domains characteristic of strain partitioning in transpression zones; in this case apparently controlled by contrasting rheologies of the juxtaposed crustal domains. The northern terrane of Wedel Jarlsberg Land shares affinities with Pearya in northern Ellesmere Island of Arctic Canada whereas the southern one resembles the Timanide belt of NE Europe. A quantitative approach facilitated by a numerical plate model demonstrates that correlation with Pearya is feasible if sinistral displacement of c. 600 km occurred during the Caledonian orogeny. The correlation with the Timanides is valid if the southern terrane represents an outlier of the Timanide belt seperated from Baltica by the opening of the lapetus Ocean.
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