SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(McMahon Katie L.) "

Sökning: WFRF:(McMahon Katie L.)

  • Resultat 11-12 av 12
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  • Gutman, Boris A, et al. (författare)
  • A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium
  • 2022
  • Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 352-372
  • Tidskriftsartikel (refereegranskat)abstract
    • Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
  •  
12.
  • Sonderby, Ida E., et al. (författare)
  • Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
  • 2020
  • Ingår i: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:3, s. 584-602
  • Tidskriftsartikel (refereegranskat)abstract
    • Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10−6, 1.7 × 10−9, 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-12 av 12
Typ av publikation
tidskriftsartikel (12)
Typ av innehåll
refereegranskat (12)
Författare/redaktör
Agartz, Ingrid (11)
Westlye, Lars T (11)
de Zubicaray, Greig ... (11)
Ehrlich, Stefan (11)
Ching, Christopher R ... (10)
Thompson, Paul M (10)
visa fler...
Andreassen, Ole A (10)
de Geus, Eco J. C. (10)
Boomsma, Dorret I. (10)
Jahanshad, Neda (10)
Crespo-Facorro, Bene ... (10)
Tordesillas-Gutierre ... (10)
Wittfeld, Katharina (10)
Fisher, Simon E. (10)
Glahn, David C. (10)
Brouwer, Rachel M (9)
Martin, Nicholas G. (9)
Stein, Dan J (9)
Sachdev, Perminder S ... (9)
Brodaty, Henry (9)
Espeseth, Thomas (9)
Andersson, Micael (8)
Nyberg, Lars, 1966- (8)
Medland, Sarah E (8)
Wright, Margaret J. (8)
Schumann, Gunter (8)
Franke, Barbara (7)
van der Meer, Dennis (7)
Cichon, Sven (7)
Le Hellard, Stephani ... (7)
Groenewold, Nynke A (7)
Grabe, Hans J. (7)
Teumer, Alexander (7)
Armstrong, Nicola J. (7)
Donohoe, Gary (7)
McDonald, Colm (6)
Djurovic, Srdjan (6)
Doan, Nhat Trung (6)
Meyer-Lindenberg, An ... (6)
Thalamuthu, Anbupala ... (6)
Schofield, Peter R (6)
Heinz, Andreas (6)
Ames, David (6)
Hottenga, Jouke-Jan (6)
Veltman, Dick J (6)
Schmaal, Lianne (6)
Schork, Andrew J (6)
Desrivieres, Sylvane (6)
Ophoff, Roel A (6)
Buckner, Randy L. (6)
visa färre...
Lärosäte
Karolinska Institutet (12)
Umeå universitet (11)
Uppsala universitet (5)
Stockholms universitet (2)
Göteborgs universitet (1)
Linköpings universitet (1)
visa fler...
Lunds universitet (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (12)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (12)
Naturvetenskap (2)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy