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Numrering	Referens	Omslagsbild	Hitta
51.	Herrera-Luis, E, et al. (författare) Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth 2022 Ingår i: Thorax. - 1468-3296. Tidskriftsartikel (refereegranskat)
52.	Herrera-Luis, E, et al. (författare) Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth 2023 Ingår i: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 78:3, s. 233-241 Tidskriftsartikel (refereegranskat)abstract In the USA, genetically admixed populations have the highest asthma prevalence and severe asthma exacerbations rates. This could be explained not only by environmental factors but also by genetic variants that exert ethnic-specific effects. However, no admixture mapping has been performed for severe asthma exacerbations.ObjectiveWe sought to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups by means of admixture mapping analyses and fine mapping, and to assess their transferability to other populations and potential functional roles.MethodsWe performed an admixture mapping in 1124 Puerto Rican and 625 Mexican American children with asthma. Fine-mapping of the significant peaks was performed via allelic testing of common and rare variants. We performed replication across Hispanic/Latino subgroups, and the transferability to non-Hispanic/Latino populations was assessed in 1001 African Americans, 1250 Singaporeans and 941 Europeans with asthma. The effects of the variants on gene expression and DNA methylation from whole blood were also evaluated in participants with asthma and in silico with data obtained through public databases.ResultsGenomewide significant associations of Indigenous American ancestry with severe asthma exacerbations were found at 5q32 in Mexican Americans as well as at 13q13-q13.2 and 3p13 in Puerto Ricans. The single nucleotide polymorphism (SNP) rs1144986 (C5orf46) showed consistent effects for severe asthma exacerbations across Hispanic/Latino subgroups, but it was not validated in non-Hispanics/Latinos. This SNP was associated withDPYSL3DNA methylation andSCGB3A2gene expression levels.ConclusionsAdmixture mapping study of asthma exacerbations revealed a novel locus that exhibited Hispanic/Latino-specific effects and regulatedDPYSL3andSCGB3A2.
53.	Melen, E, et al. (författare) Genome-wide association study of body mass index in 23 000 individuals with and without asthma 2013 Ingår i: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. - : Wiley. - 1365-2222. ; 43:4, s. 463-474 Tidskriftsartikel (refereegranskat)
54.	Min, JL, et al. (författare) Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation 2021 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 53:9, s. 1311- Tidskriftsartikel (refereegranskat)
55.	Philips, EM, et al. (författare) Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births 2020 Ingår i: PLoS medicine. - : Public Library of Science (PLoS). - 1549-1676. ; 17:8, s. e1003182- Tidskriftsartikel (refereegranskat)
56.	Santos-Valente, E, et al. (författare) Biologicals in childhood severe asthma: the European PERMEABLE survey on the status quo 2021 Ingår i: ERJ open research. - 2312-0541. ; 7:3 Tidskriftsartikel (refereegranskat)
57.	Andersen, ZJ, et al. (författare) Air pollution and COVID-19: clearing the air and charting a post-pandemic course: a joint workshop report of ERS, ISEE, HEI and WHO 2021 Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 58:2 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
58.	Artigas, MS, et al. (författare) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation 2015 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 8658- Tidskriftsartikel (refereegranskat)abstract Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
59.	Bousquet, J, et al. (författare) Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis 2015 Ingår i: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 70:9, s. 1062-1078 Tidskriftsartikel (refereegranskat)
60.	Bousquet, J, et al. (författare) ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020) 2021 Ingår i: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 76:3, s. 689-697 Tidskriftsartikel (refereegranskat)

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Författare/redaktör: Melen, E (474); Kull, I (187); Bergstrom, A (130); Pershagen, G (109); Wickman, M (108); Bousquet, J (81); visa fler...; Anto, JM (67); Koppelman, GH (67); Hallberg, J (67); Gruzieva, O (60); van Hage, M (50); Sunyer, J (49); Kere, J (49); Soderhall, C (48); Merid, SK (48); Keil, T (46); Heinrich, J. (44); Haahtela, T (43); Bedbrook, A (42); Gehring, U (42); Mullol, J (42); Zuberbier, T (39); Annesi-Maesano, I (39); Samolinski, B (39); Yorgancioglu, A (38); Guerra, S (36); Standl, M (36); Kuna, P (36); Custovic, A (36); Sheikh, A (35); Bachert, C (34); Klimek, L (34); Valiulis, A. (34); Kabesch, M (33); Ekstrom, S. (33); Valenta, R (31); Pfaar, O (31); Andersson, N (31); Lau, S (31); Kvedariene, V (31); Bustamante, M (30); Bindslev-Jensen, C (29); Valovirta, E. (29); Almqvist, C (28); Just, J (28); Morais-Almeida, M. (28); Postma, DS (27); Garcia-Aymerich, J (27); Cruz, AA (27); Devillier, P. (27); visa färre...

Lärosäte: Karolinska Institutet (478); Uppsala universitet (27); Lunds universitet (18); Göteborgs universitet (15); Umeå universitet (8); Linköpings universitet (7); visa fler...; Örebro universitet (4); Högskolan Kristianstad (3); Kungliga Tekniska Högskolan (2); Mittuniversitetet (2); visa färre...

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