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Sökning: WFRF:(Muller H)

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891.
  • Niiranen, Susa, et al. (författare)
  • Combined effects of global climate change and regional ecosystem drivers on an exploited marine food web
  • 2013
  • Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 19:11, s. 3327-3342
  • Tidskriftsartikel (refereegranskat)abstract
    • Changes in climate, in combination with intensive exploitation of marine resources, have caused large-scale reorganizations in many of the world's marine ecosystems during the past decades. The Baltic Sea in Northern Europe is one of the systems most affected. In addition to being exposed to persistent eutrophication, intensive fishing, and one of the world's fastest rates of warming in the last two decades of the 20th century, accelerated climate change including atmospheric warming and changes in precipitation is projected for this region during the 21st century. Here, we used a new multi-model approach to project how the interaction of climate, nutrient loads and cod fishing may affect the future of the open Central Baltic Sea food web. Regionally downscaled global climate scenarios were, in combination with three nutrient load scenarios, used to drive an ensemble of three regional biogeochemical models (BGMs). An Ecopath with Ecosim food web model was then forced with the BGM results from different nutrient-climate scenarios in combination with two different cod fishing scenarios. The results showed that regional management is likely to play a major role in determining the future of the Baltic Sea ecosystem. By the end of the 21st century, for example, the combination of intensive cod fishing and high nutrient loads projected a strongly eutrophicated and sprat-dominated ecosystem, while low cod fishing in combination with low nutrient loads resulted in a cod-dominated ecosystem with eutrophication levels close to present. Also, non-linearities were observed in the sensitivity of different trophic groups to nutrient loads or fishing depending on the combination of the two. Finally, many climate variables and species biomasses were projected to levels unseen in the past. Hence, the risk for ecological surprises needs to be addressed, particularly when the results are discussed in the ecosystem-based management context.
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892.
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893.
  • Ogishi, M, et al. (författare)
  • Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency
  • 2022
  • Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 219:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and to IL-12 and IL-23 (underlying mycobacterial diseases). Cells homozygous for the common P1104A TYK2 allele have selectively impaired responses to IL-23 (underlying isolated mycobacterial disease). We report three new forms of TYK2 deficiency in six patients from five families homozygous for rare TYK2 alleles (R864C, G996R, G634E, or G1010D) or compound heterozygous for P1104A and a rare allele (A928V). All these missense alleles encode detectable proteins. The R864C and G1010D alleles are hypomorphic and loss-of-function (LOF), respectively, across signaling pathways. By contrast, hypomorphic G996R, G634E, and A928V mutations selectively impair responses to IL-23, like P1104A. Impairment of the IL-23–dependent induction of IFN-γ is the only mechanism of mycobacterial disease common to patients with complete TYK2 deficiency with or without TYK2 expression, partial TYK2 deficiency across signaling pathways, or rare or common partial TYK2 deficiency specific for IL-23 signaling.
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894.
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895.
  • Olofsson, Henrik, 1972, et al. (författare)
  • CO line observations of OH/IR stars in the inner Galactic Bulge: Characteristics of stars at the tip of the AGB
  • 2022
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 665
  • Tidskriftsartikel (refereegranskat)abstract
    • Context. OH/IR stars are examples of late stellar evolution on the asymptotic giant branch (AGB), and they are, as such, important objects to study. They are also excellent probes of stellar populations, in particular in regions of high interstellar extinction such as the central regions of our Galaxy. Aims. Our goal is to characterise the stellar and circumstellar properties of high-mass-loss-rate OH/IR stars in the inner Galactic Bulge using the Atacama Large Millimeter/submillimeter Interferometer (ALMA). Methods. Rotational lines of (CO)-C-12 and (CO)-C-13, as well as a millimetre-wave continuum, have been observed for a sample of 22 OH/IR stars in directions within 2 degrees of the Galactic Centre. Photometry data (approximate to 1-30 mu m) have been gathered from the literature to construct spectral energy distributions (SEDs) and to determine pulsational variability. Radiative transfer models have been used to interpret the line and photometry data. Results. All stars in the sample were detected in at least one CO line, and eight objects were detected in 324 GHz continuum. Based on luminosity criteria, the sample is divided into 17 objects that most likely lie within the inner Galactic Bulge, and five objects that are most likely foreground objects. The median luminosity of the inner-Galactic-Bulge sub-sample, 5600 L-circle dot, corresponds to an initial mass in the range 1.2-1.6 M-circle dot, indicating that these inner-Galactic-Bulge OH/IR stars descend from solar-type stars. The objects in this sub-sample are further divided into two classes based on their SED characteristics: Eleven objects have SEDs that are well matched by models invoking dust envelopes extending from a few stellar radii and outwards, while six objects are better modelled as having detached dust envelopes with inner radii in the range 200-600 au and warmer central stars. The former objects have periodic variability, while the latter objects are predominantly non-periodic. The median gas-mass-loss rate, gas terminal expansion velocity, gas-to-dust mass ratio, and circumstellar (CO)-C-12/(CO)-C-13 abundance ratio have been estimated to be 2 x 10(-5) M-circle dot yr(-1), 18 km s(-1), 200 (excluding the sources with detached dust envelopes, which show markedly lower gas-to-dust ratios), and 5, respectively, for the inner-Galactic-Bulge sub-sample. All line brightness distributions are resolved at an angular scale of approximate to 0 ''.15, but only two objects show a structure in their circumstellar envelopes at our resolution and sensitivity. In both cases, this structure takes the form of a cavity and a bipolar morphology. Conclusions. The inner-Galactic-Bulge sub-sample consists of high mass-loss-rate stars that descend from solar-type progenitors and that lie near the tip of the AGB. Some of the sample stars may have recently ceased mass loss and, hence, have begun to evolve beyond the AGB, as evidenced by a change in circumstellar characteristics and indications of warmer central stars. The inferred very low stellar C-12/C-13 isotope ratios are indicative of CNO-cycle nuclear processing, and they are most likely established at the surfaces of the stars during the first dredge-up on the red giant branch since these stars are not expected to experience hot-bottom burning. The inner-Galactic-Bulge OH/IR stars studied here constitute an excellent sample of equidistant objects for the purpose of understanding the evolution of the mass-loss-rate characteristics at the tip of the AGB.
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896.
  • Onori, F., et al. (författare)
  • The nuclear transient AT 2017gge : a tidal disruption event in a dusty and gas-rich environment and the awakening of a dormant SMBH
  • 2022
  • Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 517:1, s. 76-98
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the results from a dense multwavelength [optical/UV, near-infrared (IR), and X-ray] follow-up campaign of the nuclear transient AT 2017gge, covering a total of 1698 d from the transient's discovery. The bolometric light curve, the blackbody temperature and radius, the broad H and He i lambda 5876 emission lines and their evolution with time, are all consistent with a tidal disruption event (TDE) nature. A soft X-ray flare is detected with a delay of similar to 200 d with respect to the optical/UV peak and it is rapidly followed by the emergence of a broad He ii lambda 4686 and by a number of long-lasting high ionization coronal emission lines. This indicate a clear connection between a TDE flare and the appearance of extreme coronal line emission (ECLEs). An IR echo, resulting from dust re-radiation of the optical/UV TDE light is observed after the X-ray flare and the associated near-IR spectra show a transient broad feature in correspondence of the He i lambda 10830 and, for the first time in a TDE, a transient high-ionization coronal NIR line (the [Fe xiii] lambda 10798) is also detected. The data are well explained by a scenario in which a TDE occurs in a gas-and-dust rich environment and its optical/UV, soft X-ray, and IR emission have different origins and locations. The optical emission may be produced by stellar debris stream collisions prior to the accretion disc formation, which is instead responsible for the soft X-ray flare, emitted after the end of the circularization process.
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897.
  • Orthofer, M, et al. (författare)
  • Identification of ALK in Thinness
  • 2020
  • Ingår i: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 181:6, s. 1246-
  • Tidskriftsartikel (refereegranskat)
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898.
  • Osmanovic, Alma, et al. (författare)
  • Heterozygous DHTKD1 Variants in Two European Cohorts of Amyotrophic Lateral Sclerosis Patients
  • 2022
  • Ingår i: Genes. - : MDPI. - 2073-4425 .- 2073-4425. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive upper and lower motor neuron (LMN) loss. As ALS and other neurodegenerative diseases share genetic risk factors, we performed whole-exome sequencing in ALS patients focusing our analysis on genes implicated in neurodegeneration. Thus, variants in the DHTKD1 gene encoding dehydrogenase E1 and transketolase domain containing 1 previously linked to 2-aminoadipic and 2-oxoadipic aciduria, Charcot-Marie-Tooth (CMT) disease type 2, and spinal muscular atrophy (SMA) were identified. In two independent European ALS cohorts (n = 643 cases), 10 sporadic cases of 225 (4.4%) predominantly sporadic patients of cohort 1, and 12 familial ALS patients of 418 (2.9%) ALS families of cohort 2 harbored 14 different rare heterozygous DHTKD1 variants predicted to be deleterious. Four DHTKD1 variants were previously described pathogenic variants, seven were recurrent, and eight were located in the E1_dh dehydrogenase domain. Nonsense variants located in the E1_dh domain were significantly more prevalent in ALS patients versus controls. The phenotype of ALS patients carrying DHTKD1 variants partially overlapped with CMT and SMA by presence of sensory impairment and a higher frequency of LMN-predominant cases. Our results argue towards rare heterozygous DHTKD1 variants as potential contributors to ALS phenotype and, possibly, pathogenesis.
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899.
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900.
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