| 1911. |
- Timpka, Simon, et al.
(författare)
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Short-term association between outdoor temperature and the hydration-marker copeptin : a pooled analysis in five cohorts
- 2023
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Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 95
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.FINDINGS: We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p < 0.0001). Between 0 °C and nadir at the 75th temperature percentile (corresponding to 14.3 °C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 °C.INTERPRETATION: The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.FUNDING: Swedish Research Council, Å Wiberg, M Stephen, A Påhlsson, Crafoord and Swedish Heart-Lung Foundations, Swedish Society for Medical Research and Swedish Society of Medicine.
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| 1912. |
- Tirado Aldana, Carlos, 1991-
(författare)
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The psychophysics of human echolocation
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Echolocation is the capacity to detect, localize, discriminate, and, overall, gather spatial information from sound reflections. Since we began studying it in humans, we have learned several things. First, most humans can echolocate to some degree. Second, the capacity to echolocate is related to: the type and size of the object that the individual is trying to echolocate; how well the individual can use self-generated or artificial signals; and the distance to the object. Third, the blind tend to perform better than the sighted, although some sighted individuals can perform as well as the blind. It has been speculated that expert echolocators are capable of unlearning the precedence effect (PE), which is the tendency of our auditory system to prioritize spatial information coming from the first wave front instead of the spatial information from the second wave front. This would allow them to obtain more spatial information from echoes, but there is little research linking the PE to echolocation skills, which is why my thesis research has explored this matter. Another contribution of my thesis research was to introduce two new concepts: echo-detection and echo-localization. Echo-detection is the ability to detect an object using echoes as the main cue (“Is the object there, yes or no?”), whereas echo-localization is the ability both to detect and also localize an object using echoes as the main cue (“Is the object situated to the right or left?”). The reason for dividing echolocation into these two tasks is that detecting an echo does not necessarily entail knowing its location. No previous study has compared these two distinct abilities. Echo-detection and echo-localization, though linked to each other, could be influenced by different mechanisms. The aim of this thesis was to explore individual differences in echo-detection, echo-localization, and other fundamental psychoacoustic abilities (i.e., PE and different types of masking) in inexperienced, sighted individuals. This included using a novel tool to train and assess echolocation skills: the Echobot. The Echobot is a machine that automates stimulus presentation. It allows an aluminum disk to be moved to different distances and different echolocation signals to be tested simultaneously. Its main advantage consists of facilitating the use of rigorous psychophysical methods that would otherwise take a long time to perform correctly. Studies I and II focused on individual differences in fundamental hearing abilities that are prerequisites for echo-detection and echo-localization (i.e., PE components and different types of masking). Studies III and IV focused on using the Echobot to study individual performance differences in echo-detection and echo-localization tasks. Overall, the results indicate that echolocation was possible for most participants, regardless of the method or signal used. There were substantial individual differences, and a performance gap between echo-detection and echo-localization appeared in several individuals. Echo-localization was usually more difficult than echo-detection, since spatial information was the hardest to retrieve from the localization tasks. It was possible to close the task performance gap in some individuals through training, but only for time intervals between direct and reflected sound of >20 ms, for which the PE might not operate. Hence, the possibility of “unlearning” the PE to improve echolocation skills remains speculative. Finally, the Echobot proved useful for studying echolocation. Taken together, these results suggest that independent mechanisms make the localization of spatial information more difficult than pure detection. However, in long-inter-click-interval (ICI) conditions, the neural mechanisms are likely mediated by attention and cognitive processes, which are more plastic, and participants can learn to obtain echo-localization information as effectively as echo-detection information. In short-ICI conditions, neural mechanisms seem more related to peripheral and temporal processing, which are potentially less plastic. Further research into individual differences in temporal processing, using brain-imaging techniques such as EEG, might help us understand the different mechanisms influencing echo-detection and echo-localization.
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| 1913. |
- Tirado, Carlos, et al.
(författare)
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Comparing Echo-Detection and Echo-Localization in Sighted Individuals
- 2021
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Ingår i: Perception. - : SAGE Publications. - 0301-0066 .- 1468-4233. ; 50:4, s. 308-327
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Tidskriftsartikel (refereegranskat)abstract
- Echolocation is the ability to gather information from sound reflections. Most previous studies have focused on the ability to detect sound reflections, others on the ability to localize sound reflections, but no previous study has compared the two abilities in the same individuals. Our study compared echo-detection (reflecting object present or not?) and echo-localization (reflecting object to the left or right?) in 10 inexperienced sighted participants across 10 distances (1-4.25 m) to the reflecting object, using an automated system for studying human echolocation. There were substantial individual differences, particularly in the performance on the echo-localization task. However, most participants performed better on the detection than the localization task, in particular at the closest distances (1 and 1.7 m), illustrating that it sometimes may be hard to perceive whether an audible reflection came from the left or right.
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| 1914. |
- Tirado, Carlos, et al.
(författare)
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Individual differences in the ability to access spatial information in lag-clicks
- 2021
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Ingår i: Journal of the Acoustical Society of America. - : Acoustical Society of America (ASA). - 0001-4966 .- 1520-8524. ; 149:5, s. 2963-2975
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Tidskriftsartikel (refereegranskat)abstract
- It may be difficult to determine whether a dichotic lag-click points to the left or right when preceded by a diotic lead-click. Previous research suggests that this loss of spatial information is most prominent at inter-click intervals (ICIs) <10 ms. However, a study by Nilsson, Tirado, and Szychowska [(2019). J. Acoust. Soc. Am. 145, 512–524] found support for loss of spatial information in lag-clicks at much longer ICIs using a stimulus setup differing from those in previous research. The present study used a setup similar to that of the Nilsson, Tirado, and Szychowska study [(2019). J. Acoust. Soc. Am. 145, 512–524] to measure 13 listeners' ability to lateralize (left versus right) and detect (present versus absent) the lag-click in lead–lag click pairs with ICIs of 6–48 ms. The main finding was distinct individual differences in performance. Some listeners could lateralize lag-clicks all the way down to their detection threshold, whereas others had lateralization thresholds substantially higher than their detection thresholds, i.e., they could not lateralize lag-clicks that they could easily detect. Two such listeners trained for 30 days and managed to improve their lateralization thresholds to reach their detection thresholds, but only at longer ICIs (>20 ms), suggesting different mechanisms underlying lag-click lateralization at short versus long ICIs.
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| 1915. |
- Tirado, Carlos, et al.
(författare)
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The Echobot : An automated system for stimulus presentation in studies of human echolocation
- 2019
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:10
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Tidskriftsartikel (refereegranskat)abstract
- Echolocation is the detection and localization of objects by listening to the sounds they reflect. Early studies of human echolocation used real objects that the experimental leader positioned manually before each experimental trial. The advantage of this procedure is the use of realistic stimuli; the disadvantage is that manually shifting stimuli between trials is very time consuming making it difficult to use psychophysical methods based on the presentation of hundreds of stimuli. The present study tested a new automated system for stimulus presentation, the Echobot, that overcomes this disadvantage. We tested 15 sighted participants with no prior experience of echolocation on their ability to detect the reflection of a loudspeaker-generated click from a 50 cm circular aluminum disk. The results showed that most participants were able to detect the sound reflections. Performance varied considerably, however, with mean individual thresholds of detection ranging from 1 to 3.2 m distance from the disk. Three participants in the loudspeaker experiment also tested using self-generated vocalization. One participant performed better using vocalization and one much worse than in the loudspeaker experiment, illustrating that performance in echolocation experiments using vocalizations not only measures the ability to detect sound reflections, but also the ability to produce efficient echolocation signals. Overall, the present experiments show that the Echobot may be a useful tool in research on human echolocation.
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| 1916. |
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| 1917. |
- Tong, Cheuk Hei Marcus, et al.
(författare)
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A drained nutrient-poor peatland forest in boreal Sweden constitutes a net carbon sink after integrating terrestrial and aquatic fluxes
- 2024
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Ingår i: Global Change Biology. - 1354-1013 .- 1365-2486. ; 30
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Tidskriftsartikel (refereegranskat)abstract
- Northern peatlands provide a globally important carbon (C) store. Since the beginning of the 20th century, however, large areas of natural peatlands have been drained for biomass production across Fennoscandia. Today, drained peatland forests constitute a common feature of the managed boreal landscape, yet their ecosystem C balance and associated climate impact are not well understood, particularly within the nutrient-poor boreal region. In this study, we estimated the net ecosystem carbon balance (NECB) from a nutrient-poor drained peatland forest and an adjacent natural mire in northern Sweden by integrating terrestrial carbon dioxide (CO2) and methane (CH4) fluxes with aquatic losses of dissolved organic C (DOC) and inorganic C based on eddy covariance and stream discharge measurements, respectively, over two hydrological years. Since the forest included a dense spruce-birch area and a sparse pine area, we were able to further evaluate the effect of contrasting forest structure on the NECB and component fluxes. We found that the drained peatland forest was a net C sink with a 2-year mean NECB of −115 ± 5 g C m−2 year−1 while the adjacent mire was close to C neutral with 14.6 ± 1.7 g C m−2 year−1. The NECB of the drained peatland forest was dominated by the net CO2 exchange (net ecosystem exchange [NEE]), whereas NEE and DOC export fluxes contributed equally to the mire NECB. We further found that the C sink strength in the sparse pine forest area (−153 ± 8 g C m−2 year−1) was about 1.5 times as high as in the dense spruce-birch forest area (−95 ± 8 g C m−2 year−1) due to enhanced C uptake by ground vegetation and lower DOC export. Our study suggests that historically drained peatland forests in nutrient-poor boreal regions may provide a significant net ecosystem C sink and associated climate benefits.
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| 1918. |
- Tong, Cheuk Hei Marcus, et al.
(författare)
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Drainage ditch cleaning has no impact on the carbon and greenhouse gas balances in a recent forest clear-cut in boreal Sweden
- 2022
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Ingår i: Forests. - : MDPI AG. - 1999-4907. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Ditch cleaning (DC) is increasingly applied to facilitate forest regeneration following clear-cutting in Fennoscandinavia. However, its impact on the ecosystem carbon and greenhouse gas (GHG) balances is poorly understood. We conducted chamber measurements to assess the initial DC effects on carbon dioxide (CO2) and methane (CH4) fluxes in a recent forest clear-cut on wet mineral soil in boreal Sweden. Measurements were conducted in two adjacent areas over two pre-treatments (2018/19) and two years (2020/21) after conducting DC in one area. We further assessed the spatial variation of fluxes at three distances (4, 20, 40 m) from ditches. We found that DC lowered the water table level by 12 +/- 2 cm (mean +/- standard error) and topsoil moisture by 0.12 +/- 0.01 m(3) m(-3). DC had a limited initial effect on the net CO2 exchange and its component fluxes. CH4 emissions were low during the dry pre-treatment years but increased particularly in the control area during the wet years of 2020/21. Distance to ditch had no consistent effects on CO2 and CH4 fluxes. Model extrapolations suggest that annual carbon emissions decreased over the four years from 6.7 +/- 1.4 to 1.6 +/- 1.6 t-C ha(-1) year(-1), without treatment differences. Annual CH4 emissions contributed <2.5% to the carbon balance but constituted 39% of the GHG balance in the control area during 2021. Overall, our study suggests that DC modified the internal carbon cycling but without significant impact on the carbon and GHG balances.
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| 1919. |
- Tong, Cheuk Hei Marcus, et al.
(författare)
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Initial effects of post-harvest ditch cleaning on greenhouse gas fluxes in a hemiboreal peatland forest
- 2022
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Ingår i: Geoderma. - : Elsevier BV. - 0016-7061 .- 1872-6259. ; 426
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Tidskriftsartikel (refereegranskat)abstract
- Ditch cleaning (DC) is a well-established forestry practice across Fennoscandia to lower water table levels (WTL) and thereby facilitate the establishment of tree seedlings following clear-cutting. However, the implications from these activities for ecosystem-atmosphere greenhouse gas (GHG) exchanges are poorly understood at present. We assessed the initial DC effects on the GHG fluxes in a forest clear-cut on a drained fertile peatland in hemiboreal Sweden, by comparing chamber measurements of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) fluxes from soil and ditches in DC and uncleaned (UC) areas over the first two post-harvest years. We also evaluated spatial effects by comparing fluxes at 4 m and 40 m from ditches. We found that 2 years after DC, mean (+/- standard error) WTL of-65 +/- 2 cm was significantly lower in the DC area compared to-56 +/- 2 cm in the UC area. We further observed lower gross primary production and ecosystem respiration in the first year after DC which coincided with delayed development of herbaceous ground vegetation. We also found higher CH4 uptake but no difference in N2O fluxes after DC. Greater CH4 uptake occurred at 4 m compared to 40 m away from both cleaned and uncleaned ditches. Model extrapolation suggests that total annual GHG emissions in the second year were reduced from 49.4 +/- 17.0 t-CO2-eq-ha(-1) -year(-1) in the UC area to 27.8 +/- 10.3 t-CO2-eq-ha(-1) -year(-1) in the DC area. A flux partitioning approach suggested that this was likely caused by decreased heterotrophic respiration, possibly because of enhanced soil dryness following DC during the dry meteorological conditions. CH(4 )and N2O fluxes from clear-cut areas contributed < 2 % to the total (soil, ditches) GHG budget. Similarly the area -weighted contributions by CO2 and CH4 emissions from both cleaned and uncleaned ditches were < 2 %. Thus, our study highlights that DC may considerably alter the post-harvest GHG fluxes of drained peatland forests. However, long-term observations under various site conditions and forest rotation stages are warranted to better understand DC effects on the forest GHG balance.
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| 1920. |
- Toomingas, Allan, et al.
(författare)
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Outcome of the abduction external rotation test among manual and office workers
- 1991
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Ingår i: American Journal of Industrial Medicine. - : Wiley. - 0271-3586 .- 1097-0274. ; 19:2, s. 215-227
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Tidskriftsartikel (refereegranskat)abstract
- Reactions during the Abduction External Rotation (AER) test were studied among 71 platers and 70 assemblers exposed to vibratory tools and manual work and 45 unexposed white collar workers. The frequency of positive neurological reactions was 31% among the platers, 6% among the assemblers, and 16% among the white collar workers. Platers reported the highest fatigue rates in the shoulder regions during the test. A positive association was noted between a pathological AER test and current problems in the neck/scapula or shoulder/upper arm regions, day- or night-time numbness in the hands, tension neck, and carpal tunnel syndrome. Age, length of daily vibration exposure, and vibration acceleration level were also positively associated with a positive AER test outcome. The results indicate that the outcome of the AER test is sensitive to neck and shoulder disorders but also, to some extent, to the carpal tunnel syndrome.
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