| 11. |
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| 12. |
- Hagberg, Hans, et al.
(författare)
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Follicular lymphoma in Sweden: nationwide improved survival in the rituximab era, particularly in elderly women: a Swedish Lymphoma Registry Study
- 2015
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 29:3, s. 668-676
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Tidskriftsartikel (refereegranskat)abstract
- Treatment for follicular lymphoma (FL) improved with rituximab. In Sweden, first-line rituximab was gradually introduced between 2003 and 2007, with regional differences. The first national guidelines for FL were published in November 2007, recommending rituximab in first-line therapy. Using the population-based Swedish Lymphoma Registry, 2641 patients diagnosed with FL from 2000 to 2010 were identified and characterized by year and region of diagnosis, age (median, 65 years), gender (50% men), first-line therapy and clinical risk factors. Overall and relative survivals were estimated by calendar periods (2000-2002, 2003-2007 and 2008-2010) and region of diagnosis. With each period, first-line rituximab use and survival increased. Survival was superior in regions where rituximab was quickly adopted and inferior where slowly adopted. These differences were independent in multivariable analyses. Ten-year relative survival for patients diagnosed 2003-2010 was 92%, 83%, 78% and 64% in the age groups 18-49, 50-59, 60-69 and ≥70, respectively. With increasing rituximab use, male sex emerged as an adverse factor. Survival improved in all patient categories, particularly in elderly women. The introduction and the establishment of rituximab have led to a nationwide improvement in FL survival. However, rituximab might be inadequately dosed in younger women and men of all ages. © 2015 Macmillan Publishers Limited. All rights reserved.
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| 13. |
- Houston, Ben, et al.
(författare)
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Hierarchical RLE level set : A compact and versatile deformable surface representation
- 2006
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Ingår i: ACM Transactions on Graphics. - : Association for Computing Machinery (ACM). - 0730-0301 .- 1557-7368. ; 25:1, s. 151-175
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Tidskriftsartikel (refereegranskat)abstract
- This article introduces the Hierarchical Run-Length Encoded (H-RLE) Level Set data structure. This novel data structure combines the best features of the DT-Grid ( of Nielsen and Museth [ 2004]) and the RLE Sparse Level Set ( of Houston et al. [ 2004]) to provide both optimal efficiency and extreme versatility. In brief, the H- RLE level set employs an RLE in a dimensionally recursive fashion. The RLE scheme allows the compact storage of sequential nonnarrowband regions while the dimensionally recursive encoding along each axis efficiently compacts nonnarrowband planes and volumes. Consequently, this new structure can store and process level sets with effective voxel resolutions exceeding 5000 x 3000 x 3000 ( 45 billion voxels) on commodity PCs with only 1 GB of memory. This article, besides introducing the H- RLE level set data structure and its efficient core algorithms, also describes numerous applications that have benefited from our use of this structure: our unified implicit object representation, efficient and robust mesh to level set conversion, rapid ray tracing, level set metamorphosis, collision detection, and fully sparse fluid simulation ( including RLE vector and matrix representations.) Our comparisons of the popular octree level set and Peng level set structures to the H- RLE level set indicate that the latter is superior in both narrowband sequential access speed and overall memory usage.
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| 14. |
- Khorram-Manesh, Amir, 1958, et al.
(författare)
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Adrenocortical carcinoma: surgery and mitotane for treatment and steroid profiles for follow-up.
- 1998
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Ingår i: World journal of surgery. - 0364-2313. ; 22:6
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Tidskriftsartikel (refereegranskat)abstract
- Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis. It has been difficult to establish a strict treatment program for ACC, and better treatment alternatives and diagnostic tools must be sought. Even though surgery is the treatment of choice, the role of surgery in advanced disease has been questioned. Eighteen consecutive patients were treated at our unit over a 22-year period (1975-1997). All patients underwent surgery and were followed by our protocol, which includes urinary steroid profiles, clinical examinations, analysis of steroid hormones, and radiologic investigations. Twelve patients received mitotane with drug concentration measurements to deliver an effective, nontoxic dose. The median duration of mitotane treatment was 12 months. Few side effects were observed. Four patients with low-stage tumors underwent second-look operations with no pathologic findings. Five patients were subjected to repeat operations, and the mean duration of the disease-free interval before repeat surgery for these patients was 59 months. There was a significant positive correlation between the disease-free interval and the observed survival after repeat surgery. Eleven patients with intentionally curative surgery had their urinary steroid profiles tested several times postoperatively. For five patients preoperative urine samples were also available. Steroid profiles indicated recurrent disease despite normal radiologic findings in two of these five patients. The follow-up ranged from 6 weeks to 24 years. The predicted 5-year survival was 58% according to the Kaplan-Meier method. We conclude that monitoring serum concentrations of mitotane makes long-term treatment possible with few side effects; steroid profile analysis can be used for early detection of tumor recurrence; and repeat surgery for recurrence is of value for patients with long disease-free intervals.
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| 15. |
- Kraxner, Florian, et al.
(författare)
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Planning the future forests: managing for wildlife in a climate constrained landscape
- 2017
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Ingår i: Book of Abstracts. - 9783902762887 ; , s. 655-
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Konferensbidrag (refereegranskat)abstract
- Multipurpose functionality is a paradigm when it comes to forest management. This includes sustainability, resilience, stand stability, wildlife management, recreation, clean water and air, or healthy soils - to name a few. The world is aiming at a maximum global warming of 2-deg by 2100, but cumulative emissions are still rising. Higher temperatures are associated with higher risks of extreme events such as storm, flood, droughts, pests and fires etc. - and at the same time, forest systems are key for any mitigation activity to avoid such dangerous climate change. But how will a managed forest look like in the future? How can we understand the underlying dynamics and make our forests fit for the increased need for carbon storage, biomass for energy and sustainable wood and non-wood forest products like game, while maintaining biodiversity, recreational and protected areas. Moreover, we need to address all challenges on limited land and establish action from policy development allthe way to their implementation within a short time frame. Based on Sweden's forests, traditionally considered a role model for successfully bridging a multitude of demands, we present a modeling approach that should serve as a planning tool for enhancing forests' risk resilience and capacity of integrating diverse demands and different ecosystem-services. Guided by the expertise of Sweden's Environmental Protection Agency, national forest and habitat shift models from SLU and KTH will be linked with global land use models and engineering tools from IIASA. Hereby, special emphasis will be put on ecosystem services from wildlife, different scenarios of forest intensification and the optimization of biomass for bioenergy production. First estimates show that spatially explicit modeling can substantially support decision making by optimizing multipurpose use of both managed and protected areas and steering habitat shift for maintaining biodiversity and improving wildlife (game)management.
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| 16. |
- Kurkus, Jan, et al.
(författare)
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Biocompatibility of a novel avidin-agarose adsorbent for extracorporeal removal of redundant radiopharmaceutical from the blood.
- 2007
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Ingår i: Artificial Organs. - : Wiley. - 0160-564X .- 1525-1594. ; 31:3, s. 208-214
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Tidskriftsartikel (refereegranskat)abstract
- The use of monoclonal antibodies (MAbs) in cytotoxic conjugates (radionuclides, toxins, or drugs) for targeting tumor cells is restricted due to toxicity in vital organs. Through improved tumor targeting, it is possible to administer larger amounts of such labeled MAbs, thus improving the ability to eradicate tumor cells without increased normal organ toxicity. Extracorporeal affinity adsorption treatment (ECAT) has therefore been developed using an avidin-agarose (AA) adsorbent with high binding affinity for the biotinylated radiolabeled MAb, rituximab. During ECAT, excess radioimmunoconjugates, not bound to the tumor cells, can be removed improving tumor targeting. The present study was performed to estimate the biocompatibility of the AA adsorber. Seven patients with B-cell lymphoma not responding to conventional treatment were studied. During the ECAT procedure, blood (B) components, plasma (P) complement fragments C3a, C5a, and P-bradykinin were analyzed, and other laboratory tests were carried out. Slight decreases in B-hemoglobin (8.3%), B-thrombocytes (11.4%), and P-albumin (14.3%) were observed, and could be explained by the dilution of the blood with normal saline and acid citrate dextrose. The AA adsorbent had no effect on the blood cells, immunological status or P-bradykinin level. The AA adsorber demonstrated good hemocompatibility and biocompatibility, without any side effects in the patients.
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| 17. |
- Kölby, Lars, 1963, et al.
(författare)
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A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake.
- 2001
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Ingår i: The American journal of pathology. - 0002-9440. ; 158:2, s. 745-55
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Tidskriftsartikel (refereegranskat)abstract
- A human midgut carcinoid tumor was successfully transplanted into nude mice and propagated for five consecutive generations (30 months) with well-preserved phenotype. Tumor cells in nude mice expressed identical neuroendocrine markers as the original tumor, including somatostatin receptors (somatostatin receptors 1 to 5) and vesicular monoamine transporters (VMAT1 and VMAT2). Because of the expression of somatostatin receptors and VMAT1 and VMAT2 the grafted tumors could be visualized scintigraphically using the somatostatin analogue 111In-octreotide and the catecholamine analogue 123I-metaiodobenzylguanidine. The biokinetics of the somatostatin analogue 111In-octreotide in the tumors was studied and showed a high retention 7 days after administration. Cell cultures were re-established from transplanted tumors. Immunocytochemical and ultrastructural studies confirmed the neuroendocrine differentiation. The human origin of transplanted tumor cells was confirmed by cytogenetic and fluorescence it situ hybridization analyses. Spontaneous secretion of serotonin and its metabolite, 5-hydroxyindole acetic acid, from tumor cells was demonstrated. The tumor cells increased their [Ca2+]i in response to beta-adrenoceptor stimulation (isoproterenol) and K+-depolarization. All somatostatin receptor subtypes could be demonstrated in cultured cells. This human transplantable carcinoid tumor, designated GOT1, grafted to nude mice, will give unique possibilities for studies of somatostatin receptor- and VMAT-mediated radionuclide uptake as well as for studies of secretory mechanisms.
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| 18. |
- Nielsen, Michael B., et al.
(författare)
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Out-of-core and compressed level set methods
- 2007
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Ingår i: ACM Transactions on Graphics. - : ACM. - 0730-0301 .- 1557-7368. ; 26:4, s. 16-
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Tidskriftsartikel (refereegranskat)abstract
- This article presents a generic framework for the representation and deformation of level set surfaces at extreme resolutions. The framework is composed of two modules that each utilize optimized and application specific algorithms: 1) A fast out-of-core data management scheme that allows for resolutions of the deforming geometry limited only by the available disk space as opposed to memory, and 2) compact and fast compression strategies that reduce both offline storage requirements and online memory footprints during simulation. Out-of-core and compression techniques have been applied to a wide range of computer graphics problems in recent years, but this article is the first to apply it in the context of level set and fluid simulations. Our framework is generic and flexible in the sense that the two modules can transparently be integrated, separately or in any combination, into existing level set and fluid simulation software based on recently proposed narrow band data structures like the DT-Grid of Nielsen and Museth [2006] and the H-RLE of Houston et al. [2006]. The framework can be applied to narrow band signed distances, fluid velocities, scalar fields, particle properties as well as standard graphics attributes like colors, texture coordinates, normals, displacements etc. In fact, our framework is applicable to a large body of computer graphics problems that involve sequential or random access to very large co-dimension one (level set) and zero (e.g. fluid) data sets. We demonstrate this with several applications, including fluid simulations interacting with large boundaries (? 15003), surface deformations (? 20483), the solution of partial differential equations on large surfaces (˜40963) and mesh-to-level set scan conversions of resolutions up to ? 350003 (7 billion voxels in the narrow band). Our out-of-core framework is shown to be several times faster than current state-of-the-art level set data structures relying on OS paging. In particular we show sustained throughput (grid points/sec) for gigabyte sized level sets as high as 65% of state-of-the-art throughput for in-core simulations. We also demonstrate that our compression techniques out-perform state-of-the-art compression algorithms for narrow bands. © 2007 ACM.
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| 19. |
- Nilsson, Ola B., et al.
(författare)
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Cotranslational folding of spectrin domains via partially structured states
- 2017
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Ingår i: Nature Structural & Molecular Biology. - : Springer Science and Business Media LLC. - 1545-9993 .- 1545-9985. ; 24:3, s. 221-225
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Tidskriftsartikel (refereegranskat)abstract
- How do the key features of protein folding, elucidated from studies on native, isolated proteins, manifest in cotranslational folding on the ribosome? Using a well-characterized family of homologous α-helical proteins with a range of biophysical properties, we show that spectrin domains can fold vectorially on the ribosome and may do so via a pathway different from that of the isolated domain. We use cryo-EM to reveal a folded or partially folded structure, formed in the vestibule of the ribosome. Our results reveal that it is not possible to predict which domains will fold within the ribosome on the basis of the folding behavior of isolated domains; instead, we propose that a complex balance of the rate of folding, the rate of translation and the lifetime of folded or partly folded states will determine whether folding occurs cotranslationally on actively translating ribosomes.
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| 20. |
- Nilsson, Ola B., et al.
(författare)
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Cotranslational Protein Folding inside the Ribosome Exit Tunnel
- 2015
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 12:10, s. 1533-1540
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Tidskriftsartikel (refereegranskat)abstract
- At what point during translation do proteins fold? It is well established that proteins can fold cotranslationally outside the ribosome exit tunnel, whereas studies of folding inside the exit tunnel have so far detected only the formation of helical secondary structure and collapsed or partially structured folding intermediates. Here, using a combination of co-translational nascent chain force measurements, inter-subunit fluorescence resonance energy transfer studies on single translating ribosomes, molecular dynamics simulations, and cryoelectron microscopy, we show that a small zinc-finger domain protein can fold deep inside the vestibule of the ribosome exit tunnel. Thus, for small protein domains, the ribosome itself can provide the kind of sheltered folding environment that chaperones provide for larger proteins.
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