SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Nobili F.) "

Search: WFRF:(Nobili F.)

  • Result 61-70 of 88
Sort/group result
   
EnumerationReferenceCoverFind
61.
  •  
62.
  •  
63.
  •  
64.
  • Frisoni, Giovanni B., et al. (author)
  • European intersocietal recommendations for the biomarker-based diagnosis of neurocognitive disorders
  • 2024
  • In: The Lancet Neurology. - 1474-4422 .- 1474-4465. ; 23:3, s. 302-312
  • Research review (peer-reviewed)abstract
    • The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease emphasises the need for consensus recommendations on the rational use of biomarkers to diagnose people with suspected neurocognitive disorders in memory clinics. Most available recommendations and guidelines are either disease-centred or biomarker-centred. A European multidisciplinary taskforce consisting of 22 experts from 11 European scientific societies set out to define the first patient-centred diagnostic workflow that aims to prioritise testing for available biomarkers in individuals attending memory clinics. After an extensive literature review, we used a Delphi consensus procedure to identify 11 clinical syndromes, based on clinical history and examination, neuropsychology, blood tests, structural imaging, and, in some cases, EEG. We recommend first-line and, if needed, second-line testing for biomarkers according to the patient's clinical profile and the results of previous biomarker findings. This diagnostic workflow will promote consistency in the diagnosis of neurocognitive disorders across European countries.
  •  
65.
  •  
66.
  •  
67.
  •  
68.
  •  
69.
  •  
70.
  • Kruse, N., et al. (author)
  • Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study
  • 2015
  • In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 36:9, s. 2587-2596
  • Journal article (peer-reviewed)abstract
    • Decreased levels of alpha-synuclein (aSyn) in cerebrospinal fluid (CSF) in Parkinson's disease and related synucleinopathies have been reported, however, not consistently in all cross-sectional studies. To test the performance of one recently released human-specific enzyme-linked immunosorbent assay (ELISA) for the quantification of aSyn in CSF, we carried out a round robin trial with 18 participating laboratories trained in CSF ELISA analyses within the BIOMARKAPD project in the EU Joint Program -Neurodegenerative Disease Research. CSF samples (homogeneous aliquots from pools) and ELISA kits (one lot) were provided centrally and data reported back to one laboratory for data analysis. Our study showed that although factors such as preanalytical sample handling and lot-to-lot variability were minimized by our study design, we identified high variation in absolute values of CSF aSyn even when the same samples and same lots of assays were applied. We further demonstrate that although absolute concentrations differ between laboratories the quantitative results are comparable. With further standardization this assay may become an attractive tool for comparing aSyn measurements in diverse settings. Recommendations for further validation experiments and improvement of the interlaboratory results obtained are given. (C) 2015 Elsevier Inc. All rights reserved.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 61-70 of 88

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view