| 61. |
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| 62. |
- Lindberg, Jonas, et al.
(författare)
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Religion och politik
- 2022. - 2
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Ingår i: Sociologiska perspektiv på religion i Sverige. - 9789151107479
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 63. |
- Lindgren, Åsa, et al.
(författare)
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Tornedalens bergsbruk under 1600-talet: Rapport över specialinventering och kartering hösten 2017 : Leppäskoski hytta/Pahtavaara gruvområde, Jukkasjärvi 1, 1931, Svappavaara hyttby, Jukkasjärvi 256, Svappavaara gruvby, Jukkasjärvi 2636, Masugnsbys bruksområde, Jukkasjärvi 44, Kalix kopparbruk, Nederkalix 36
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)
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| 64. |
- Linge, Helena, et al.
(författare)
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Midkine is expressed and differentially processed during COPD exacerbations and ventilator-associated pneumonia associated with Staphylococcus aureus infection.
- 2013
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Ingår i: Molecular medicine (Cambridge, Mass.). - : Springer Science and Business Media LLC. - 1528-3658 .- 1076-1551. ; 19, s. 314-323
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Tidskriftsartikel (refereegranskat)abstract
- Staphylococcus aureus is sometimes isolated from the airways during acute exacerbations of chronic obstructive pulmonary disease (COPD) but more commonly recognized as a cause of ventilator-associated pneumonia (VAP). Antimicrobial proteins, among them midkine (MK), are an important part of innate immunity in the airways. In this study, the levels and possible processing of MK in relation to S. aureus infection of the airways were investigated, comparing COPD and VAP, thus comparing a state of disease with preceding chronic inflammation and remodeling (COPD) with acute inflammation (i.e. VAP). MK was detected in the small airways and alveoli of COPD lung tissue but less so in normal lung tissue. MK at below micromolar concentrations killed S. aureus in vitro. Proteolytic processing of MK by the staphylococcal metalloprotease AL but not cysteine protease SA, resulted in impaired bactericidal activity. Degradation was foremost seen in the COOH-terminal portion of the molecule that harbors high bactericidal activity. In addition, MK was detected in sputum from patients suffering from VAP caused by S. aureus but less so in sputum from COPD-exacerbations associated with the same bacterium. Recombinant MK was degraded more rapidly in sputum from the COPD patients than from the VAP patients and a greater proteolytic activity in COPD sputum was confirmed by zymography. Taken together, proteases of both bacteria and the host contribute to degradation of the antibacterial protein MK, resulting in an impaired defense of the airways, in particular in COPD where the state of chronic inflammation could be of importance.
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| 65. |
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| 66. |
- M Abdillahi, Suado, et al.
(författare)
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Collagen VI Is Upregulated in COPD and Serves Both as an Adhesive Target and a Bactericidal Barrier for Moraxella catarrhalis.
- 2015
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Ingår i: Journal of Innate Immunity. - : S. Karger AG. - 1662-811X .- 1662-8128. ; 7:5, s. 506-517
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Tidskriftsartikel (refereegranskat)abstract
- Moraxella catarrhalis is a Gram-negative human mucosal commensal and pathogen. It is a common cause of exacerbation in chronic obstructive pulmonary disease (COPD). During the process of infection, host colonization correlates with recognition of host molecular patterns. Importantly, in COPD patients with compromised epithelial integrity the underlying extracellular matrix is exposed and provides potential adhesive targets. Collagen VI is a ubiquitous fibrillar component in the airway mucosa and has been attributed both adhesive and killing properties against Gram-positive bacteria. However, less is known regarding Gram-negative microorganisms. Therefore, in the present study, the interaction of M. catarrhalis with collagen VI was characterized. We found that collagen VI is upregulated in the airways of COPD patients and exposed upon epithelial desquamation. Ex vivo, we inoculated airway biopsies and fibroblasts from COPD patients with M. catarrhalis. The bacteria specifically adhered to collagen VI-containing matrix fibrils. In vitro, purified collagen VI microfibrils bound to bacterial surface structures. The primary adhesion target was mapped to the collagen VI α2-chain. Upon exposure to collagen VI, bacteria were killed by membrane destabilization in physiological conditions. These previously unknown properties of collagen VI provide novel insights into the extracellular matrix innate immunity by quickly entrapping and killing pathogen intruders. © 2015 S. Karger AG, Basel.
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| 67. |
- Magnusson, Börje, et al.
(författare)
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Drömmen om stormakten : Erik Dahlberghs Sverige
- 2015
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Ingen har betytt så mycket för bilden av den svenska stormakten, dess städer och slott, som Erik Dahlbergh, Han påbörjade 1661 det svindlande projektet att avbilda sevärdheter från alla delar av Sverige. Den ambitiösa satsningen resulterade i verket Suecia antiqua et hodierna, "Det forna och nuvarande Sverige", med en stor mängd planscher som återutgivits under århundraden. Länge ansågs verket framställa Sverige som mer storslaget än det faktiskt var. Men hur är det egentligen med överdrifterna? Och vilka är människorna som rör sig i slottsmiljöerna? Vad kan vi från bilderna utläsa om livet i den svenska stormakten? Konsthistorikerna Börje Magnusson och historikern Jonas Nordin går på en fascinerande upptäcktsfärd i 1600-talets Sverige.
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| 68. |
- Malmgren, Linnea, et al.
(författare)
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The complexity of kidney disease and diagnosing it - Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation.
- 2023
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Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 293:3, s. 293-308
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Tidskriftsartikel (refereegranskat)abstract
- Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous GFR-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterised by a selective reduction in the glomerular filtration of 5-30 kDa molecules, such as cystatin C, compared to the filtration of small molecules < 1kDa dominating the glomerular filtrate e.g., water, urea, creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine-based GFR-estimates. The syndromes are characterised by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor-blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C-based GFR-estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines.
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| 69. |
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Media & Mediation in the Eighteenth Century
- 2023
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- While eighteenth-century print media in essence rested on the same technical apparatus as previous centuries – letterpress printing, woodcuts, and intaglio prints – the growth in quantity created a media revolution. The effect was a qualitative shift in terms of literacy, growth of newspapers, the spread of images, and distribution of knowledge, but also of misinformation and propaganda. In this volume eight scholars investigate various aspects of media and mediation in the history, culture, and politics of the eighteenth century.
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| 70. |
- Monié Nordin, Jonas
(författare)
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A Baroque Landscape of Earth, Water and Fire: : The Production of Space at Skokloster, a Swedish Estate of the Seventeenth Century
- 2015
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Ingår i: Landscapes. - : Routledge. - 1466-2035. ; 16:2, s. 126-144
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Tidskriftsartikel (refereegranskat)abstract
- This article uses the elemental concepts of earth, water and fire to examine theproduction, use and control of space in the seventeenth-century Wrangelestate at Skokloster in central Sweden. Using a relational approach, thepaper discusses how the elements symbolically express a part of thebaroque aesthetic, how they were emphasised or pinned down as part of aneconomic asset, and how they reacted and produced space in dialogue withhuman agents. The reciprocal relations between man and earth throughfood production, tenancy and rent, or the management of woodland for firewood,demonstrate an on-going interaction between various socially-hierarchicalagents. The construction of dams and the control of water illustrate otherstruggles between the tenants, the proprietor and the water itself. Whensetting up new types of heating systems inside the castle multiple sourcesof agency are visualised – the owners, the domestic servants, the woodlandand the fireplaces. The study concludes that the elements operated as morethan aesthetic and philosophical categories, but were empirically-evidentworldly driving-forces.
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