| 31. |
- Johansson, Maria, et al.
(författare)
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Perceived outdoor lighting quality POLQ. A lighting assessment tool
- 2014
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Ingår i: Journal of Environmental Psychology. - : Elsevier BV. - 1522-9610 .- 0272-4944. ; 39, s. 14-21
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Tidskriftsartikel (refereegranskat)abstract
- Abstract in UndeterminedA shift towards more energy-efficient light sources for outdoor lighting such as light-emitting diodes (LEDs) is underway. Photometric measures are not sufficient to capture how users experience the light, so complementary tools are required. This study aimed to develop an observer-based environmental assessment tool, based on bipolar semantic differentials, for outdoor lighting in urban spaces. Exploratory (N = 130) and confirmatory (N = 117) factor analyses of observations of lighting installations made by laypersons on-site along pedestrian paths, resulted in two dimensions of high reliability: the Perceived Strength Quality (PSQ, Cronbach's alpha = 0.82–0.85) and the Perceived Comfort Quality (PCQ, Cronbach's alpha = 0.77–0.81). PSQ and PCQ differentiated between light sources of different illuminance level, colour temperature and colour rendering. Regression analyses showed that the perceived lighting qualities helped to explain the variance in visual accessibility, whereas PCQ helped to explain perceived danger in the environment. The perceived lighting qualities can add to the understanding of pedestrians' perception of outdoor lighting, and is proposed as a complementary tool for development of sustainable light designs in the urban environment
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| 32. |
- Johansson, Maria, et al.
(författare)
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The feared object in fear of brown bear and wolf
- 2012
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Ingår i: HUMAN EXPERIENCE IN THE NATURAL AND BUILT ENVIRONMENT: IMPLICATIONS FOR RESEARCH POLICY & PRACTICE (IAPS 22 Conference, Abstracts of Presentations).
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Konferensbidrag (refereegranskat)
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| 33. |
- Kalscheuer, Thomas, et al.
(författare)
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Non-linear model error and resolution properties from two-dimensional single and joint inversions of direct current resistivity and radiomagnetotelluric data
- 2010
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Ingår i: Geophysical Journal International. - 0956-540X .- 1365-246X. ; 182:3, s. 1174-1188
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Tidskriftsartikel (refereegranskat)abstract
- P>For the first time, a comparative analysis of the resolution and variance properties of 2-D models of electrical resistivity derived from single and joint inversions of dc resistivity (DCR) and radiomagnetotelluric (RMT) measurements is presented. DCR and RMT data are inverted with a smoothness-constrained 2-D scheme. Model resolution, model variance and data resolution analyses are performed both with a classical linearized scheme that employs the smoothness-constrained generalized inverse and a non-linear truncated singular value decomposition (TSVD). In the latter method, the model regularization used in the inversion is avoided and non-linear semi-axes give an approximate description of the non-linear confidence surface in the directions of the model eigenvectors. Hence, this method analyses the constraints that can be provided by the data. Model error estimates are checked against improved and independent estimates of model variability from most-squares inversions. For single and joint inverse models of synthetic data sets, the smoothness-constrained scheme suggests relatively small model errors (typically up to 30 to 40 per cent) and resolving kernels that are spread over several cells in the vicinity of the investigated cell. Linearized smoothness-constrained errors are in good agreement with the corresponding most-squares errors. The variability of the RMT model as estimated from non-linear semi-axes is confirmed by TSVD-based most-squares inversions for most model cells within the depth range of investigation. In contrast to this, most-squares errors of the DCR model are consistently larger than errors estimated from non-linear semi-axes except for the smallest truncation levels. The model analyses confirm previous studies that DCR data can constrain resistive and conductive structures equally well while RMT data provide superior constraints for conductive structures. The joint inversion can improve error and resolution of structures which are within the depth ranges of exploration of both methods. In such parts of the model which are outside the depth range of exploration for one method, error and resolution of the joint inverse model are close to those of the best single inversion result subject to an appropriate weighting of the different data sets.
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| 34. |
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| 35. |
- Kilpeläinen, Tuomas O, et al.
(författare)
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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
- 2011
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Ingår i: PLoS medicine. - : Public Library of Science (PLoS). - 1549-1676 .- 1549-1277. ; 8:11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) = 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.
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| 36. |
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| 37. |
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| 38. |
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| 39. |
- Magnusson, Patrik K. E., et al.
(författare)
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The Swedish Twin Registry : establishment of a biobank and other recent developments
- 2013
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Ingår i: Twin Research and Human Genetics. - Cambridge, United Kingdom : Cambridge University Press. - 1832-4274 .- 1839-2628. ; 16:1, s. 317-329
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Tidskriftsartikel (refereegranskat)abstract
- The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.
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| 40. |
- Merlo, Domenico Franco, et al.
(författare)
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Micronuclei in Cord Blood Lymphocytes and Associations with Biomarkers of Exposure to Carcinogens and Hormonally Active Factors, Gene Polymorphisms, and Gene Expression : The NewGeneris Cohort
- 2014
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Ingår i: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 122:2, s. 193-200
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Tidskriftsartikel (refereegranskat)abstract
- Background: Leukemia incidence has increased in recent decades among European children, -suggesting that early-life environmental exposures play an important role in disease development. Objectives: We investigated the hypothesis that childhood susceptibility may increase as a result of in utero exposure to carcinogens and hormonally acting factors. Using cord blood samples from the NewGeneris cohort, we examined associations between a range of biomarkers of carcinogen exposure and hormonally acting factors with micronuclei (MN) frequency as a proxy measure of cancer risk. Associations with gene expression and genotype were also explored. Methods: DNA and protein adducts, gene expression profiles, circulating hormonally acting factors, and GWAS (genome-wide association study) data were investigated in relation to genomic damage measured by MN frequency in lymphocytes from 623 newborns enrolled between 2006 and 2010 across Europe. Results: Malondialdehyde DNA adducts (M(1)dG) were associated with increased MN frequency in binucleated lymphocytes (MNBN), and exposure to androgenic, estrogenic, and dioxin-like compounds was associated with MN frequency in mononucleated lymphocytes (MNMONO), although no monotonic exposure-outcome relationship was observed. Lower frequencies of MNBN were associated with a 1-unit increase expression of PDCD11, LATS2, TRIM13, CD28, SMC1A, IL7R, and NIPBL genes. Gene expression was significantly higher in association with the highest versus lowest category of bulky and M(1)dG-DNA adducts for five and six genes, respectively. Gene expression levels were significantly lower for 11 genes in association with the highest versus lowest category of plasma AR CALUX (R) (chemically activated luciferase expression for androgens) (8 genes), ER alpha CALUX (R) (for estrogens) (2 genes), and DR CALUX (R) (for dioxins). Several SNPs (single-nucleotide polymorphisms) on chromosome 11 near FOLH1 significantly modified associations between androgen activity and MNBN frequency. Polymorphisms in EPHX1/ 2 and CYP2E1 were associated with MNBN. Conclusion: We measured in utero exposure to selected environmental carcinogens and circulating hormonally acting factors and detected associations with MN frequency in newborns circulating T lymphocytes. The results highlight mechanisms that may contribute to carcinogen-induced leukemia and require further research.
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