SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Perez E.) "

Sökning: WFRF:(Perez E.)

  • Resultat 2121-2130 av 2439
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
2121.
  •  
2122.
  •  
2123.
  •  
2124.
  • Kasho, Kazutoshi, et al. (författare)
  • A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol
  • 2021
  • Ingår i: Nucleic acids research. - : Oxford University Press (OUP). - 1362-4962 .- 0305-1048. ; 49:4, s. 2179-2191
  • Tidskriftsartikel (refereegranskat)abstract
    • Replication forks often stall at damaged DNA. To overcome these obstructions and complete the DNA duplication in a timely fashion, replication can be restarted downstream of the DNA lesion. In mammalian cells, this repriming of replication can be achieved through the activities of primase and polymerase PrimPol. PrimPol is stimulated in DNA synthesis through interaction with PolDIP2, however the exact mechanism of this PolDIP2-dependent stimulation is still unclear. Here, we show that PrimPol uses a flexible loop to interact with the C-terminal ApaG-like domain of PolDIP2, and that this contact is essential for PrimPol's enhanced processivity. PolDIP2 increases primer-template and dNTP binding affinities of PrimPol, which concomitantly enhances its nucleotide incorporation efficiency. This stimulation is dependent on a unique arginine cluster in PolDIP2. Since the polymerase activity of PrimPol alone is very limited, this mechanism, where the affinity for dNTPs gets increased by PolDIP2 binding, might be critical for the in vivo function of PrimPol in tolerating DNA lesions at physiological nucleotide concentrations. © The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.
  •  
2125.
  •  
2126.
  • Kim, Dae-Kyum, et al. (författare)
  • EVpedia: A Community Web Portal for Extracellular Vesicles Research
  • 2015
  • Ingår i: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811. ; 31:6, s. 933-939
  • Tidskriftsartikel (refereegranskat)abstract
    • Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research.
  •  
2127.
  •  
2128.
  •  
2129.
  • Knoška, Juraj, et al. (författare)
  • Ultracompact 3D microfluidics for time-resolved structural biology
  • 2020
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11
  • Tidskriftsartikel (refereegranskat)abstract
    • To advance microfluidic integration, we present the use of two-photon additive manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with nanometer precision. We demonstrate this technique by tailoring microfluidic nozzles and mixers for time-resolved structural biology at X-ray free-electron lasers (XFELs). We achieve submicron jets with speeds exceeding 160 m s−1, which allows for the use of megahertz XFEL repetition rates. By integrating an additional orifice, we implement a low consumption flow-focusing nozzle, which is validated by solving a hemoglobin structure. Also, aberration-free in operando X-ray microtomography is introduced to study efficient equivolumetric millisecond mixing in channels with 3D features integrated into the nozzle. Such devices can be printed in minutes by locally adjusting print resolution during fabrication. This technology has the potential to permit ultracompact devices and performance improvements through 3D flow optimization in all fields of microfluidic engineering.
  •  
2130.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 2121-2130 av 2439
Typ av publikation
tidskriftsartikel (2147)
konferensbidrag (106)
forskningsöversikt (35)
bokkapitel (6)
rapport (5)
annan publikation (3)
visa fler...
visa färre...
Typ av innehåll
refereegranskat (2323)
övrigt vetenskapligt/konstnärligt (97)
populärvet., debatt m.m. (2)
Författare/redaktör
Meyer, J. (785)
Zhu, J. (722)
Zhou, B. (685)
Price, D. (683)
Evans, H. (681)
Lokajicek, M. (680)
visa fler...
Fox, H. (677)
Quadt, A. (677)
Kupco, A. (675)
Sawyer, L. (675)
Abbott, B. (674)
Brandt, A. (674)
Brock, R. (674)
Burdin, S. (674)
Kehoe, R. (674)
Neal, H. A. (674)
Pleier, M. -A. (674)
Qian, J. (674)
Snyder, S. (674)
Stark, J. (674)
Borissov, G. (673)
Cooke, M. (673)
Khanov, A. (673)
Schwienhorst, R. (673)
Simak, V. (673)
Watts, G. (673)
Fiedler, F. (672)
Hohlfeld, M. (672)
Shabalina, E. (672)
Strauss, M. (672)
Rizatdinova, F. (671)
Filthaut, F. (670)
Sanders, M. P. (670)
Severini, H. (670)
Tsybychev, D. (670)
Hubacek, Z. (669)
Liu, Y. (668)
Nunnemann, T. (668)
Schamberger, R. D. (665)
Denisov, S. P. (664)
Han, L. (664)
Skubic, P. (662)
Zieminska, D. (660)
Gutierrez, P. (659)
Grivaz, J. -F. (659)
Vokac, P. (631)
Brandt, O. (623)
Schwanenberger, C. (620)
Chakraborty, D. (611)
White, A. (611)
visa färre...
Lärosäte
Uppsala universitet (984)
Lunds universitet (764)
Stockholms universitet (694)
Karolinska Institutet (545)
Kungliga Tekniska Högskolan (450)
Göteborgs universitet (145)
visa fler...
Chalmers tekniska högskola (142)
Umeå universitet (93)
Linnéuniversitetet (89)
Linköpings universitet (35)
Sveriges Lantbruksuniversitet (17)
Mittuniversitetet (14)
Högskolan Dalarna (14)
Örebro universitet (11)
RISE (10)
Högskolan i Skövde (9)
Luleå tekniska universitet (6)
Högskolan i Halmstad (5)
Malmö universitet (5)
Jönköping University (4)
Karlstads universitet (4)
Mälardalens universitet (3)
Naturhistoriska riksmuseet (3)
Gymnastik- och idrottshögskolan (2)
Blekinge Tekniska Högskola (2)
Högskolan i Gävle (1)
Handelshögskolan i Stockholm (1)
Södertörns högskola (1)
Marie Cederschiöld högskola (1)
visa färre...
Språk
Engelska (2435)
Svenska (2)
Polska (1)
Portugisiska (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1436)
Medicin och hälsovetenskap (343)
Teknik (66)
Samhällsvetenskap (19)
Lantbruksvetenskap (15)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy