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Sökning: WFRF:(Petersson Maria)

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21.
  • Andersson, Maria L. E., et al. (författare)
  • Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis
  • 2013
  • Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 14
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Currently available biomarkers for the early tissue process leading to joint damage in rheumatoid arthritis are insufficient and lack prognostic accuracy, possibly a result of variable activity of the disease over time. This study represents a novel approach to detect an altered activity of the disease process detected as increasing serum-COMP levels over a short time and whether this would correlate with joint damage progression over the first 5 years of disease. Methods: In all, 349 patients from the Swedish BARFOT early RA study were examined. Serum-COMP was analysed by ELISA at diagnosis and after 3 months. Based on changes in serum-COMP levels, three subgroups of patients were defined: those with unchanged levels (change <= 20%) (N=142), decreasing levels (> 20%) (N=173) and increasing levels (> 20%) (N=34). Radiographs of hands and feet were obtained at inclusion, after 1, 2 and 5 years and scored according to Sharp van der Heijde (SHS). Radiographic progression was defined as increase in SHS by >= 5.8. Results: The group of patients with increasing COMP levels showed higher median change in total SHS and erosion scores at 1, 2 and 5 year follow-up compared with the groups with stable or decreasing COMP levels. Furthermore, the odds ratio of radiographic progression was 2.8 (95% CI 1.26-6.38) for patients with increasing COMP levels vs. patients with unchanged levels. The group of patients with increasing COMP levels had higher ESR at inclusion but there were no baseline differences between the groups for age, gender, disease duration, disease activity (DAS28), function (HAQ), CRP, nor presence of rheumatoid factor or anti-CCP. Importantly, neither did changes over the 3-month period in DAS28, HAQ, ESR nor CRP differ between the groups and these variables did not correlate to joint damage progression. Conclusion: Increasing serum-COMP levels between diagnosis and the subsequent 3 months in patients with early RA represents a novel indicator of an activated destructive process in the joint and is a promising tool to identify patients with significant joint damage progression during a 5-year period.
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22.
  • Andersson, Maria, et al. (författare)
  • Serum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis
  • 2006
  • Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: COMP (Cartilage oligomeric matrix protein) is a matrix protein, which is currently studied as a potential serum marker for cartilage processes in osteoarthritis (OA). The influence of physical exercise on serum COMP is not fully elucidated. The objective of the present study was to monitor serum levels of COMP during a randomised controlled trial of physical exercise vs. standardised rest in individuals with symptomatic and radiographic knee OA. Methods: Blood samples were collected from 58 individuals at predefined time points before and after exercise or rest, one training group and one control group. The physical exercise consisted of a one-hour supervised session twice a week and daily home exercises. In a second supplementary study 7 individuals were subjected to the same exercise program and sampling of blood was performed at fixed intervals before, immediately after, 30 and 60 minutes after the exercise session and then with 60 minutes interval for another five hours after exercise to monitor the short-term changes of serum COMP. COMP was quantified with a sandwich-ELISA (AnaMar Medical, Lund, Sweden). Results: Before exercise or rest no significant differences in COMP levels were seen between the groups. After 60 minutes exercise serum COMP levels increased (p<0.001). After 60 minutes of rest the serum levels decreased (p=0.003). Median serum COMP values in samples obtained prior to exercise or rest at baseline and after 24 weeks did not change between start and end of the study. In the second study serum COMP was increased immediately after exercise (p=0.018) and had decreased to baseline levels after 30 minutes. Conclusion: Serum COMP levels increased during exercise in individuals with knee OA, whereas levels decreased during rest. The increased serum COMP levels were normalized 30 minutes after exercise session, therefore we suggest that samples of blood for analysis of serum COMP should be drawn after at least 30 minutes rest in a seated position. No increase was seen after a six-week exercise program indicating that any effect of individualized supervised exercise on cartilage turnover is transient.
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23.
  • André-Petersson, Lena, et al. (författare)
  • Social support at work and the risk of myocardial infarction and stroke in women and men.
  • 2007
  • Ingår i: Social Science and Medicine. - : Elsevier BV. - 1873-5347 .- 0277-9536. ; 64:4, s. 830-841
  • Tidskriftsartikel (refereegranskat)abstract
    • It has been proposed that lack of social support in a work place characterized by high levels of stress, may increase the likelihood of future cardiovascular disease. The aim of this study was to analyze the prospective impact of social support at work in combination with self-reported work stress on incidence of myocardial infarction (MI) and stroke in a cohort of 4707 women (mean age: 54.2 years) and 3063 men (mean age: 55.5 years) in Malmo, Sweden. The results are based oil self-reports of work-related stress and social support collected at baseline examinations between the years 1992 and 1996. Work-stress was operationalized according to the Karasek job strain model. Data on incidence of NIL and stroke were obtained from national and regional registers. At the end of follow-up, December 31, 2001, 38 women had experienced an MI and 53 had had a stroke. Corresponding figures for men were 114 MIs and 81 strokes. The first finding was that social support at work was an independent predictor of an M I and stroke among women. The second finding was that there was no evidence to support the iso-strain model. The third finding was that low levels of social support at work together with a passive work situation indicated an increased risk of a future cardiovascular outcome (NI I or stroke) during follow-up in the female group. In men, no association was found between any psychosocial work conditions and incidence of MI or stroke during the same follow-up period. (c) 2006 Elsevier Ltd. All rights reserved.
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24.
  • Annerbo, Kerstin, 1964-, et al. (författare)
  • Bibliotekarier och forskningsutställningar : "Mission impossible"?
  • 2021
  • Ingår i: När nyfikenhet, driv och kreativitet möts. - Stockholm : Kungliga biblioteket. - 9789170004315 - 9789170004322 - 9789170004339 ; , s. 53-61
  • Bokkapitel (populärvet., debatt m.m.)abstract
    • Att bibliotekens uppgifter kan skifta eller ändra fokus, så att?arbetsformer förändras och bibliotekariers roller därigenom?omformas, är varken nytt eller konstigt. Så har det alltid varit.?En av de nya rollerna för bibliotekarier som blivit vanligare?på senare år är utvecklings- och producentrollen. Ta del av ett?samtal om hur verksamheten med att skapa forskningsutställningar har utvecklats på Linköpings universitetsbibliotek.
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25.
  • Asghari, Hamid, 1967-, et al. (författare)
  • Att vara lärare för lärare : Ämnesdidaktiska syften i utbildning till yrkeslärare och ämneslärare
  • 2019
  • Ingår i: Pedagogiska utvecklingsprojekt vid Karlstads universitet. - Karlstad : Karlstads universitet. - 9789178670727 - 9789178670826 ; , s. 11-36
  • Bokkapitel (refereegranskat)abstract
    • Under 2018 genomförs ett pilotprojekt med medel från lärarutbildningsnämnden (LUN) kring hur didaktiklärarna i den korta lärarutbildningen (KUB) ser på sitt uppdrag. Frågan är viktig att belysa då didaktik utgör en stor del av lärarutbildningen. Dessutom behöver didaktikerna, utifrån de nationella examensmålen för utbildningen, bedöma vilken kunskap som undervisningen skall förmedla, hur, när och varför den ska undervisas samt att vara medvetna om samspelet mellan undervisning, lärande och resultat (jfr Bengtsson & Kroksmark, 1994; Dahlgren, 1990). I det sammanhanget blir det viktigt att undersöka hur yrkesdidaktikerna ser på sitt uppdrag och vilka kvalitéer i lärares kompetens de månar om. Inom KUB är ämnesdidaktiken insprängd i den utbildnings­vetenskapliga kärnans kurser (UK-kurserna). Studenterna är här indelade i olika (yrkes-)ämnes-didaktikgrupper beroende på ämnesinriktning. I samma kurs kan det finnas upp mot 25 olika didaktikgrupper. Sammanlagt fanns inom KUB läsåret 17/18 drygt 40 verksamma didaktiker med olika bakgrund (lektorer, adjunkter och gymnasielärare). Vid kursledarmöten, KUB-konferenser och kursvärderingar har det framkommit att det ser väldigt olika ut i samma kurs avseende vad den didaktiska delen innehåller och hur den examineras. I projektet undersöks genom textanalyser (jfr Boréus & Bergström, 2005) hur kursmålen inom didaktiken examineras och vilket innehåll som lyfts fram i samtliga 90 studiehandledningar som berör yrkesämnes och ämnesdidaktik inom YRK och KPU ht 2017. Resultaten pekar på att didaktikernas syn på sitt uppdrag skiljer sig beroende på deras utbildningsbakgrund och anställningsform. Didaktiker med forskarexamen bygger i större utsträckning sina uppgifter på forskning, har en mer vetenskaplig tolkning av lärandemålen, examinerar studenterna utifrån sin vetenskapliga tolkning av lärandemålen och använder sig utav forskningsartiklar och doktorsavhandlingar i litteraturlistan än didaktiker som inte har forskarutbildning. Didaktiker som några gånger per termin kommer från gymnasieskolor till universitet och undervisar yrkeslärarstudenter konstruerar sina uppgifter och examinerar sina studenter baserad på ”den undervisningsverklighet” studenterna kommer att möta i sina framtida yrken som yrkeslärare. De använder också oftare än didaktiker med forskarexamen texter från sina branschorganisationer i litteraturlistan.
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29.
  • Bendix, Marie, et al. (författare)
  • Insulin and glucagon in plasma and cerebrospinal fluid in suicide attempters and healthy controls
  • 2017
  • Ingår i: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 81, s. 1-7
  • Tidskriftsartikel (refereegranskat)abstract
    • Mental disorders and related behaviors such as suicidality and violence have been associated to dysregulation of e g carbohydrate metabolism. We hypothesized that patients after suicide attempt, compared to healthy controls, would have higher insulin and lower glucagon levels in plasma and cerebrospinal fluid and that these changes would be associated to violent behavior. Twenty-eight medication-free patients (10 women, 18 men), hospitalized after suicide attempt, and 19 healthy controls (7 women, 12 men) were recruited with the aim to study risk factors for suicidal behavior. Psychological/psychiatric assessment was performed with SCID I and II or the SCID interview for healthy volunteers respectively, the Karolinska Interpersonal Violence Scale (KIVS) for assessment of lifetime violence expression behavior, the Montgomery-Asberg-Depression-Scale (MADRS) and the Comprehensive Psychological Rating Scale (CPRS) for symptomatic assessment of depression and appetite. Fasting levels of insulin and glucagon were measured in plasma (P) and cerebrospinal fluid (CSF). Suicide attempters had higher insulin- and lower glucagon-levels in plasma- and CSF compared to controls. Except for P-glucagon these associations remained significant after adjusting for age and/or BMI. Patients reported significantly more expressed interpersonal violence compared to healthy volunteers. Expressed violence was significantly positively correlated with P- and CSF-insulin and showed a significant negative correlation with P-glucagon in study participants. These findings confirm and extend prior reports that higher insulin and lower glucagon levels in plasma and cerebrospinal fluid are associated with suicidal behavior pointing towards a potential autonomic dysregulation in the control of insulin and glucagon secretion in suicidal patients. 
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30.
  • Bendix, Marie, 1971- (författare)
  • Neuroendocrine studies in patients with affective disorders
  • 2019
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Background: Affective disorders are common and a major cause for increased disability and mortality worldwide. Exogenous stressors and biological variables, including neuroendocrine factors, are assumed to contribute to an increased vulnerability to mood dysregulation. Affective disorders are highly heterogeneous and different neuroendocrine systems may play differential roles in the phenotypic expression of affective disorders in men and women.Aims: The overall aim of this thesis was to study three neuroendocrine systems in relation to underlying behavioral endophenotypes (personality traits, self-directed and interpersonal violence, and psychiatric symptoms) in patients with affective disorders.Methods: In Study I oxytocin plasma levels were assessed in 101 general psychiatric outpatients and followed-up in 36 patients after one month. Patients underwent diagnostic, symptomatic, and personality trait assessments.In Study II insulin and glucagon levels in plasma and cerebrospinal fluid (CSF) were assessed in 28 patients hospitalized after a recent suicide attempt and 19 healthy controls. Study persons were assessed regarding lifetime violence expression, psychiatric diagnoses and symptoms.In Study III serum levels of allopregnanolone, progesterone and estradiol were assessed in 14 women with severe postpartum depression and psychosis who, as previously reported, responded with rapid symptom remission during sublingual estradiol treatment. Hormonal and symptomatic assessment were performed before and after 4 weeks of estradiol treatment. 28 healthy postpartum controls were included for baseline comparison.Results: I) Plasma oxytocin levels were positively associated with personality traits of impulsiveness (monotony avoidance) and negative emotionality (psychic anxiety) with potential gender differences.II) Patients after suicide attempt had higher insulin (plasma and CSF) and lower glucagon levels (CSF) than healthy controls. Insulin levels (plasma and CSF) were higher and glucagon levels (plasma) were lower in patients and controls with higher levels of prior violence expression.III) Serum allopregnanolone decreased in women with postpartum depression and psychosis during estradiol treatment. The ratio between allopregnanolone and progesterone was significantly lower in patients than in healthy controls at baseline and it remained unchanged after symptom remission.Conclusion: Behavioral endophenotypes, rather than categorical diagnoses, of affective disorders were associated with neuroendocrine variation in three different cohorts of patients with affective disorder. Hormonal variation pointed towards an association with trait, rather than state like facets of affective behavior, constituting potential vulnerability markers for affective dysregulation.
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