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Träfflista för sökning "WFRF:(Purcell S) "

Sökning: WFRF:(Purcell S)

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Numrering	Referens	Omslagsbild	Hitta
21.	Lee, SH, et al. (författare) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs 2013 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:9, s. 984- Tidskriftsartikel (refereegranskat)
22.	Musliner, KL, et al. (författare) Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population 2019 Ingår i: JAMA psychiatry. - Chicago : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 76:5, s. 516-525 Tidskriftsartikel (refereegranskat)
23.	Ripke, S, et al. (författare) Biological insights from 108 schizophrenia-associated genetic loci 2014 Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 511:7510, s. 421- Tidskriftsartikel (refereegranskat)
24.	Stahl, EA, et al. (författare) Genome-wide association study identifies 30 loci associated with bipolar disorder 2019 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:5, s. 793- Tidskriftsartikel (refereegranskat)
25.	Ripke, S, et al. (författare) Genome-wide association study identifies five new schizophrenia loci 2011 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:10, s. 969-976 Tidskriftsartikel (refereegranskat)
26.	Bikbov, B, et al. (författare) Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 2020 Ingår i: Lancet (London, England). - : Elsevier BV. - 1474-547X .- 0140-6736. ; 395:10225, s. 709-733 Tidskriftsartikel (refereegranskat)
27.	Sklar, P, et al. (författare) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 2011 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:10, s. 977-U162 Tidskriftsartikel (refereegranskat)
28.	Speliotes, Elizabeth K., et al. (författare) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010 Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948 Tidskriftsartikel (refereegranskat)abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
29.	Fullman, Nancy, et al. (författare) Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016 2018 Ingår i: The Lancet. - : Lancet Publishing Group. - 1474-547X .- 0140-6736. ; 391:10136, s. 2236-2271 Tidskriftsartikel (refereegranskat)
30.	Jia, X. M., et al. (författare) Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder 2021 Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26:9, s. 5239-5250 Tidskriftsartikel (refereegranskat)abstract Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined the protein-coding (exonic) sequences of 3,987 unrelated individuals with BD and 5,322 controls of predominantly European ancestry across four cohorts from the Bipolar Sequencing Consortium (BSC). We assessed the burden of rare, protein-altering, single nucleotide variants classified as pathogenic or likely pathogenic (P-LP) both exome-wide and within several groups of genes with phenotypic or biologic plausibility in BD. While we observed an increased burden of rare coding P-LP variants within 165 genes identified as BD GWAS regions in 3,987 BD cases (meta-analysis OR = 1.9, 95% CI = 1.3-2.8, one-sided p = 6.0 x 10(-4)), this enrichment did not replicate in an additional 9,929 BD cases and 14,018 controls (OR = 0.9, one-side p = 0.70). Although BD shares common variant heritability with schizophrenia, in the BSC sample we did not observe a significant enrichment of P-LP variants in SCZ GWAS genes, in two classes of neuronal synaptic genes (RBFOX2 and FMRP) associated with SCZ or in loss-of-function intolerant genes. In this study, the largest analysis of exonic variation in BD, individuals with BD do not carry a replicable enrichment of rare P-LP variants across the exome or in any of several groups of genes with biologic plausibility. Moreover, despite a strong shared susceptibility between BD and SCZ through common genetic variation, we do not observe an association between BD risk and rare P-LP coding variants in genes known to modulate risk for SCZ.

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