| 41. |
- Bigal, Marcelo E, et al.
(author)
-
Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study.
- 2015
-
In: Lancet Neurology. - 1474-4465. ; 14:11, s. 1091-1100
-
Journal article (peer-reviewed)abstract
- Benefits of calcitonin-gene related peptide (CGRP) inhibition have not been established in chronic migraine. Here we assess the safety, tolerability, and efficacy of two doses of TEV-48125, a monoclonal anti-CGRP antibody, in the preventive treatment of chronic migraine.
|
|
| 42. |
- Dargie, W., et al.
(author)
-
A topology control protocol based on eligibility and efficiency metrics
- 2011
-
In: Journal of Systems and Software. - : Elsevier. - 0164-1212. ; 84:1, s. 2-11
-
Journal article (peer-reviewed)abstract
- The question of fairness in wireless sensor networks is not studied very well. It is not unusual to observe in the literature fairness traded for low latency or reliability. However, a disproportional use of some critical nodes as relaying nodes can cause premature network fragmentation. This paper investigates fairness in multi-hop wireless sensor networks and proposes a topology control protocol that enables nodes to exhaust their energy fairly. Moreover, it demonstrates that whereas the number of neighboring nodes with which a node should cooperate depends on the density of the network, increasing this number beyond a certain amount does not contribute to network connectivity.
|
|
| 43. |
- Dargie, W., et al.
(author)
-
A Topology Control Protocol for 2D Poisson Distributed Wireless Sensor Networks
- 2009
-
Conference paper (peer-reviewed)abstract
- Topology control in a wireless sensor network is useful for ensuring that the network remains connected in the presence of nodes that exhaust their energy or become altogether dysfunctional (for whatever reasons). It also ensures that all the link that can be established are energy-efficient links and the nodes utilize their energy fairly. In this paper, we propose a fair and energy efficient topology control protocol for a two-dimensional random sensor deployment in which the nodes can estimate the distances to their neighbors and vary their transmission power accordingly. The protocol applies a neighbor eligibility metric in order to ensure a fair distribution of energy in the network. We introduce the notion of weighted relaying regions defined over the plane of a searching node to drop out inefficient links. Unlike most topology control protocols that rely on nearest neighbor approaches, we use a distance measure that is radio characteristic and channel condition dependent. We verify the performance of the protocol through simulation results on network graph properties and energy consumption.
|
|
| 44. |
- Kim, Min, et al.
(author)
-
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
- 2019
-
In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 15:6, s. 817-827
-
Journal article (peer-reviewed)abstract
- INTRODUCTION: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.METHODS: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.RESULTS: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.DISCUSSION: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
|
|
| 45. |
- Kurras, M., et al.
(author)
-
From Single- to Multi-User Scheduling in LTE-A Uplink Exploiting Virtual MIMO
- 2012
-
In: 2012 CONFERENCE RECORD OF THE FORTY SIXTH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS AND COMPUTERS (ASILOMAR). - : IEEE conference proceedings. ; , s. 1172-1176
-
Conference paper (peer-reviewed)abstract
- This paper focuses on frequency and spatial domain scheduling in a frequency division duplex (FDD) Long Term Evolution - Advanced (LTE-A) system for the uplink direction. First we present a single-user (SU) channel-dependent scheduling (CDS) algorithm for continuous bandwidth allocation. There, we introduce a parameter to adjust the distribution of the user throughput without any loss in system performance. This is done as a preparation for the main contribution of this paper where we take advantage of the fact that a base station (BS) in LTE-A will be equipped with two ore more receive antennas by exploiting virtual multiple-input multiple-output (MIMO) through multi-user (MU) scheduling. We take the output of the SU-algorithm and group additional user in a second spatial layer to increase the system throughput. Note that our proposed MU algorithm requires a SU scheduler considering the continuous bandwidth constraint for assigned resources per user, because we do not change scheduling decisions made by the SU algorithm. The evaluation in this paper is done by extensive system level simulations in a third generation partnership project (3GPP) conform multi-cell scenario, assuming both SU and full MU interference. Numerical results show that our MU-algorithm improves the system throughput by 25-50 % compared to SU scheduling in uplink.
|
|
| 46. |
- Labadie, Julia D., et al.
(author)
-
Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival
- 2022
-
In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 12:1
-
Journal article (peer-reviewed)abstract
- Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10–8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30–1.69, p = 8.47 × 10–9) and the proximal colon (rs189655236, HR = 2.14, 95% CI 1.65–2.77, p = 9.19 × 10–9 and rs144717887, HR = 2.01, 95% CI 1.57–2.58, p = 3.14 × 10–8), whereas no associations were detected for rectal tumors. Findings from this large genome-wide association study highlight the potential for anatomical-site-stratified genome-wide studies to identify germline genetic risk variants associated with colorectal cancer-specific survival. Larger sample sizes and further replication efforts are needed to more fully interpret these findings.
|
|
| 47. |
- Leonard, Hampton L., et al.
(author)
-
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data
- 2023
-
In: npj Parkinson's Disease. - : Springer Science and Business Media LLC. - 2373-8057. ; 9:1
-
Journal article (peer-reviewed)abstract
- Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD.
|
|
| 48. |
- Palmerio, Erika, et al.
(author)
-
CMEs and SEPs During November-December 2020 : A Challenge for Real-Time Space Weather Forecasting
- 2022
-
In: Space Weather. - : American Geophysical Union (AGU). - 1542-7390. ; 20:5
-
Journal article (peer-reviewed)abstract
- Predictions of coronal mass ejections (CMEs) and solar energetic particles (SEPs) are a central issue in space weather forecasting. In recent years, interest in space weather predictions has expanded to include impacts at other planets beyond Earth as well as spacecraft scattered throughout the heliosphere. In this sense, the scope of space weather science now encompasses the whole heliospheric system, and multipoint measurements of solar transients can provide useful insights and validations for prediction models. In this work, we aim to analyze the whole inner heliospheric context between two eruptive flares that took place in late 2020, that is, the M4.4 flare of 29 November and the C7.4 flare of 7 December. This period is especially interesting because the STEREO-A spacecraft was located similar to 60 degrees east of the Sun-Earth line, giving us the opportunity to test the capabilities of "predictions at 360 degrees" using remote-sensing observations from the Lagrange L1 and L5 points as input. We simulate the CMEs that were ejected during our period of interest and the SEPs accelerated by their shocks using the WSA-Enlil-SEPMOD modeling chain and four sets of input parameters, forming a "mini-ensemble." We validate our results using in situ observations at six locations, including Earth and Mars. We find that, despite some limitations arising from the models' architecture and assumptions, CMEs and shock-accelerated SEPs can be reasonably studied and forecast in real time at least out to several tens of degrees away from the eruption site using the prediction tools employed here.
|
|
| 49. |
|
|
| 50. |
- Rosén, Christoffer, 1986, et al.
(author)
-
Increased Levels of Chitotriosidase and YKL-40 in Cerebrospinal Fluid from Patients with Alzheimer's Disease.
- 2014
-
In: Dementia and geriatric cognitive disorders extra. - : S. Karger AG. - 1664-5464. ; 4:2, s. 297-304
-
Journal article (peer-reviewed)abstract
- The cerebrospinal fluid (CSF) biomarkers total tau, abnormally phosphorylated tau and amyloid β 1-42 are strongly associated with Alzheimer's disease (AD). Apart from the pathologic hallmarks that these biomarkers represent, other processes such as inflammation and microglial activation are present in the brains of patients with AD. New biomarkers related to these processes could be valuable for the diagnosis and follow-up of AD patients and for the evaluation of inflammation-related pathologies.
|
|
