| 31. |
- Penninx, Brenda W. J. H., et al.
(författare)
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Anxiety disorders
- 2021
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 397:10277, s. 914-927
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Tidskriftsartikel (refereegranskat)abstract
- Anxiety disorders form the most common group of mental disorders and generally start before or in early adulthood. Core features include excessive fear and anxiety or avoidance of perceived threats that are persistent and impairing. Anxiety disorders involve dysfunction in brain circuits that respond to danger. Risk for anxiety disorders is influenced by genetic factors, environmental factors, and their epigenetic relations. Anxiety disorders are often comorbid with one another and with other mental disorders, especially depression, as well as with somatic disorders. Such comorbidity generally signifies more severe symptoms, greater clinical burden, and greater treatment difficulty. Reducing the large burden of disease from anxiety disorders in individuals and worldwide can be best achieved by timely, accurate disease detection and adequate treatment administration, scaling up of treatments when needed. Evidence-based psychotherapy (particularly cognitive behavioural therapy) and psychoactive medications (particularly serotonergic compounds) are both effective, facilitating patients' choices in therapeutic decisions. Although promising, no enduring preventive measures are available, and, along with frequent therapy resistance, clinical needs remain unaddressed. Ongoing research efforts tackle these problems, and future efforts should seek individualised, more effective approaches for treatment with precision medicine.
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| 32. |
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| 33. |
- Schiele, Miriam A., et al.
(författare)
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Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders : A meta-analysis
- 2021
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Ingår i: European Neuropsychopharmacology. - : Elsevier. - 0924-977X .- 1873-7862. ; 44, s. 105-120
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Tidskriftsartikel (refereegranskat)abstract
- There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.
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| 34. |
- Schuster, Andreas, et al.
(författare)
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Function selection among popular dive computer models : A review and proposed improvements
- 2014
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Ingår i: Underwater Technology. - : Society for Underwater Technology. - 1756-0543. ; 32:3, s. 159-165
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Tidskriftsartikel (refereegranskat)abstract
- For optimal safety a dive computer should be easy to use and the displayed information easy to understand. The present study examines the usability of dive computers and potential technologies to enhance safety. It should be noted that even if the ease of use of a dive computer is increased to an extent where it is intuitive to use, this does not release the diver from the recommendation to read the dive computer manual to safely dive with it. For the present work, 47 dive computer models by 14 manufacturers were purchased and the manuals of another three were studied. Function selection was noted for each model. Where selection required a combination of long and short pushes, or more than one button, it was considered necessary to read the instruction manual merely to modify settings in the dive computer. The mean number of buttons, switches or contacts per dive computer was 3.3 (SD 1.1, range 1–7). Twelve models (24%) did not have multiple functions per button, one model (2%) had a single multi-function and 36 models (72%) had multiple multi-functions per button. Accessing these functions required short or long push combinations. In 41 out of 50 (82%) of the dive computer models, the user interface was not intuitive. The majority of popular dive computers employ combinations of long and short pushes to access multiple functions, requiring training and mnemonic effort to operate the device. They are not intuitive, and scope exists to improve the usability and safety of dive computers. Possibilities are described including touch screens, a wheel to replace traditional buttons and near field communications (NFC).
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| 35. |
- Sieber, Arne Santa, et al.
(författare)
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Compact recreational rebreather with innovative gas sensing concept and low work of breathing design
- 2013
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Ingår i: Marine Technology Society journal. - : Marine Technology Society Inc.. - 0025-3324 .- 1948-1209. ; 47:6, s. 27-41
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Tidskriftsartikel (refereegranskat)abstract
- Recreational rebreathers are increasingly popular, and recreational diver training organizations now routinely offer training for rebreather diving. Few rebreathers on the market, however, fulfill the criteria of a dedicated recreational rebreather. These remain based on traditional sensor technology, which may be linked to rebreather use having an estimated 10 times the risk of mortality while diving compared with open circuit breathing systems. In the present work, a new recreational rebreather based on two innovative approaches is described. Firstly, the rebreather uses a novel sensor system including voltammetric and spectroscopic validation of galvanic pO2 sensor cells, a redundant optical pO2 sensor, and a two-wavelength infrared pCO2 sensor. Secondly, a new breathing loop design is introduced, which reduces failure points, improves work of breathing, and can be mass fabricated at a comparatively low cost. Two prototypes were assembled and tested in the laboratory at a notified body for personal protective equipment before both pool and sea water diving trials. Work of breathing was well below the maximum allowed by the European Normative. These trials also demonstrated that optical pO2 sensors can be successfully employed in rebreathers. The pCO2 sensor detected pCO2 from 0.0004 to 0.0024 bar. These new approaches, which include a new concept for simplified mechanical design as well as improved electronic control, may prove useful in future recreational diving apparatus.
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| 36. |
- Sieber, Arne Santa, et al.
(författare)
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Head-up display system for closed circuit rebreathers with antimagnetic wireless data transmission
- 2013
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Ingår i: Marine Technology Society journal. - : Marine Technology Society Inc.. - 0025-3324 .- 1948-1209. ; 47:6, s. 42-51
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Tidskriftsartikel (refereegranskat)abstract
- Rebreather divers use LED-based head-up displays (HUD) as a primary display and warning device for the partial pressure of O2 in the breathing loop. Such devices are usually mounted on the mouthpiece of the rebreather in the field of vision of the diver. LED-based HUDs are simple devices and can be designed so that they are easy to understand but have limited information content. Few alphanumeric or graphical screen-based HUDs have been developed in the past. Connecting such a device to a rebreather requires cable links, which divers dislike, and increases the risk of entanglement. State-of-the-art wireless data transmission uses ultrasonic waves or lowfrequency electromagnetic waves; the former is not silent, and the latter achieves only very low data transmission rates of a few bytes per second and does not meet the antimagnetic standards required by military divers. The present paper describes a novel HUD system that incorporates a simple LED-based primary HUD along with an advanced secondary head-up diving computer with a micro organic LED screen. An optical infrared data transmission system is used to transmit all rebreather relevant data fromthe primary to the secondary device. One prototype of the system was manufactured and successfully tested in the laboratory according to relevant European standards as well as during several dives in fresh and sea water.
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| 37. |
- Sveningsson, Andreas, 1976, et al.
(författare)
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Modelling the Entrance Region in a Plane Asymmetric Diffuser by Elliptic Relaxation
- 2005
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Ingår i: Fourth International Symposium on Turbulence and Shear Flow Phenomena. ; 3, s. 1183-1188
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The flow in an asymmetric diffuser is computed with the non-linear V2F model suggested by Pettersson-Reif (2000). Its performance is compared with that of two linear eddy-viscosity models and all results are validated against the LES of \cite{kaltenbach99}. Several modifications to the$\varepsilon$ equation are considered and it is shown that this equation indeed plays an important role in the diffuser flow. It is shown that the non-linear relation improves the representation of the individual Reynolds stress components but deteriorates the predictions of the mean flow. Therefore an appreciable effort is spent on identifying the underlying mechanisms that control the evolution of the flow in the diffuser. It is shown that the near-wall resolution of the Reynolds stresses in the entrance region of the diffuser is of essential importance.
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| 38. |
- Thienel, Manuela, et al.
(författare)
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Immobility-associated thromboprotection is conserved across mammalian species from bear to human
- 2023
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6641, s. 178-187
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Tidskriftsartikel (refereegranskat)abstract
- Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE.
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| 39. |
- Wierenga, Lara M., et al.
(författare)
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Greater male than female variability in regional brain structure across the lifespan
- 2022
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Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 470-499
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Tidskriftsartikel (refereegranskat)abstract
- For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
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| 40. |
- Zhang, Le, et al.
(författare)
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Comedication and Polypharmacy With ADHD Medications in Adults : A Swedish Nationwide Study
- 2021
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Ingår i: Journal of Attention Disorders. - : Sage Publications. - 1087-0547 .- 1557-1246. ; 25:11, s. 1519-1528
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Evidence regarding comedication among individuals with ADHD is lacking, especially in adults. This study investigated comedication and polypharmacy with ADHD medications in adults.Method: We identified adults dispensed with ADHD medications during 2013 in Sweden and matched them to controls. Logistic regression was used to calculate odds ratios (ORs) of receiving other medications.Results: Individuals receiving ADHD medications had higher risk of receiving any major classes of somatic medications (ORs ranged from 4.1, 95% confidence interval [CI] = [4.0, 4.3], to 7.4, 95% CI = [6.5, 8.5] across age groups). They were more likely to receive respiratory system, alimentary tract and metabolic system, and cardiovascular system medications. In addition, they had higher risk of receiving any other psychotropic medications. The proportion of polypharmacy with five or more medication classes increased from 10.1% to 60.4% from 18 to 64 years. Conclusion: Comedication was more common in adults receiving ADHD medications. Potential benefits and harms of comedication and polypharmacy require further research.
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