| 441. |
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| 442. |
- Khoury, J. D., et al.
(författare)
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The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms
- 2022
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 36, s. 1703-1719
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Tidskriftsartikel (refereegranskat)abstract
- The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.
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| 443. |
- Kind, R., et al.
(författare)
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Scandinavia : A former Tibet?
- 2013
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Ingår i: Geochemistry Geophysics Geosystems. - : American Geophysical Union (AGU). - 1525-2027. ; 14:10, s. 4479-4487
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Tidskriftsartikel (refereegranskat)abstract
- The Himalaya and the Tibetan Plateau are uplifted by the ongoing northward underthrusting of the Indian continental lithosphere below Tibet resulting in lithospheric stacking. The layered structure of the Tibetan upper mantle is imaged by seismic methods, most detailed with the receiver function method. Tibet is considered as a place where the development of a future craton is currently under way. Here we study the upper mantle from Germany to northern Sweden with seismic S receiver functions and compare the structure below Scandinavia with that below Tibet. Below Proterozoic Scandinavia, we found two low-velocity zones on top of each other, separated by a high-velocity zone. The top of the upper low-velocity zone at about 100 km depth extends from Germany to Archaean northern Sweden. It agrees with the lithosphere-asthenosphere boundary (LAB) below Germany and Denmark. Below Sweden it is known as the 8 degrees discontinuity, or as a mid-lithospheric discontinuity (MLD), similar to observations in North America. Seismic tomography places the LAB near 200 km in Scandinavia, which is close to the top of our deeper low-velocity zone. We also observed the bottom of the asthenosphere (the Lehmann discontinuity) deepening from 180 km in Germany to 260 km below Sweden. Remnants of old subduction in the upper about 100 km below Scandinavia and Finland are known from controlled source seismic experiments and local earthquake studies. Recent tomographic studies indicate delamination of the lithosphere below southern Scandinavia and northern Germany. We are suggesting that the large-scale layered structure in the Scandinavian upper mantle may be caused by processes similar to the ongoing lithospheric stacking in Tibet.
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| 444. |
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| 445. |
- Kislev, T., et al.
(författare)
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On the nature of opaque cylindrical regions formed at fibre break sites in a fragmentation test
- 2002
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Ingår i: Advanced Composites Letters. - : SAGE Publications. - 0963-6935 .- 2633-366X. ; 11:1, s. 7-13
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Tidskriftsartikel (refereegranskat)abstract
- When a single-fibre composite test is performed to obtain information about the interfacial adhesion in a composite, a gradual strain increase often causes an opaque (black) cylinder to nucleate at, and grow from, the fibre failure sites. The nature of the opaque cylinder is difficult to ascertain using optical microscopy. This is the subject of the present note. To study the inside of the opaque cylinder we use several experimental methods based on imaging the failed region: optical microscopy, laser Raman spectroscopy and scanning electron microscopy. Mechanical models, including FEM analysis and analytic equations based on the shear-lag, approach, are used to discuss the experimental work. The nature and growth mechanism of the opaque cylinder are of importance in defining the parameters and/or contributions that appear in both the force balance and the. energy balance schemes.
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| 446. |
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| 447. |
- Kjaer, Susanne K., et al.
(författare)
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A Pooled Analysis of Continued Prophylactic Efficacy of Quadrivalent Human Papillomavirus (Types 6/11/16/18) Vaccine against High-grade Cervical and External Genital Lesions
- 2009
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Ingår i: Cancer Prevention Research. - 1940-6207. ; 2:10, s. 868-878
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Tidskriftsartikel (refereegranskat)abstract
- Quadrivalent human papillomavirus (HPV) vaccine has been shown to provide protection from HPV 6/11/16/18-related cervical, vaginal, and vulvar disease through 3 years. We provide an update on the efficacy of the quadrivalent HPV vaccine against high-grade cervical, vaginal, and vulvar lesions based on end-of-study data from three clinical trials. Additionally, we stratify vaccine efficacy by several baseline characteristics, including age, smoking status, and Papanicolaou (Pap) test results. A total of 18,174 females ages 16 to 26 years were randomized and allocated into one of three clinical trials (protocols 007, 013, and 015). Vaccine or placebo was given at baseline, month 2, and month 6. Pap testing was conducted at regular intervals. Cervical and anogenital swabs were collected for HPV DNA testing. Examination for the presence of vulvar and vaginal lesions was also done. Endpoints included high-grade cervical, vulvar, or vaginal lesions (CIN 2/3, VIN 2/3, or VaIN 2/3). Mean follow-up time was 42 months post dose 1. Vaccine efficacy against HPV 6/11/16/18-related high-grade cervical lesions in the per-protocol and intention-to-treat populations was 98.2% [95% confidence interval (95% CI), 93.3-99.8] and 51.5% (95% CI, 40.6-60.6), respectively. Vaccine efficacy against HPV 6/11/16/18-related high-grade vulvar and vaginal lesions in the per-protocol and intention-to-treat populations was 100.0% (95% CI, 82.6-100.0) and 79.0% (95% CI, 56.4-91.0), respectively. Efficacy in the intention-to-treat population tended to be lower in older women, women with more partners, and women with abnormal Pap test results. The efficacy of quadrivalent HPV vaccine against high-grade cervical and external anogenital neoplasia remains high through 42 months post vaccination.
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| 448. |
- Korja, Toivo, et al.
(författare)
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The geoelectric model of the POLAR Profile, Northern Finland
- 1989
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Ingår i: Tectonophysics. - : Elsevier BV. - 0040-1951 .- 1879-3266. ; 162:1-2, s. 113-133
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Tidskriftsartikel (refereegranskat)abstract
- Electromagnetic soundings have been made in order to construct a geoelectrical (conductivity) model of the crust along the European Geotraverse (EGT) POLAR Profile. Forty magnetotelluric (MT) soundings, eighteen audiomagnetotelluric (AMT) soundings and ten magnetohydrodynamic (MHD) soundings were made on the main POLAR Profile (POLAR I) and ten more MT soundings on a parallel profile (POLAR II), 40 km to the southeast of the main profile. Analysis of simultaneous recordings by the EISCAT magnetometer chain, and thin-sheet modelling of the effect of the Barents Sea, indicate that neither the source field effects nor the presence of the ocean are significant at periods below 200 s in the measurement area. The magnetotelluric data have been modelled with two-dimensional models representing the regional structure along the profiles. In addition to the regional structure, a thin inhomogeneous surface layer is included in the models in order to explain some local features of the measured response functions. Although details of the surface electrical structures are poorly resolved, the gross features of the geoelectrical cross section are considered to be reliable. The results divide the POLAR Profile into three different blocks. The better conducting Karasjok-Kittilä Greenstone Belt in the south has an average resistivity of less than 10 Ωm. The more resistant Lapland Granulite Belt, with a resistivity between 100 and 200 Ωm, is underlain by conductive (< 5 Ωm), N-dipping layers. The depth for the uppermost conductive layer varies from a few kilometres in the southwestern part of the granulite belt to 13 km in the northeastern part, from where it rises steeply towards the surface close to the boundary between the Lapland Granulite Belt and the Inari Terrain. These features appear to be continuous between the two parallel MT profiles. Within the Inari Terrain a conductive zone at an approximate depth of 10 km and with a resistivity of about 20 Ωm was identified in a resistive upper crust. The geoelectric cross section agrees, in gross detail, with the corresponding gravity, refraction seismic and reflection seismic cross sections of the POLAR Profile. All methods indicated a similar shape for the southwestern part of the Lapland Granulite Belt i.e., granulites have a gently NE-dipping boundary against the underlying Karelian Province. In the northeastern part of the granulite belt the geoelectric model and the gravimetric model show a rather steep S-dipping boundary against the Inari Terrain northeast of the granulite belt.
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| 449. |
- Krauss-Etschmann, Susanne, et al.
(författare)
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Of flies, mice and men : a systematic approach to understanding the early life origins of chronic lung disease
- 2013
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Ingår i: Thorax. - : BMJ. - 0040-6376 .- 1468-3296. ; 68:4, s. 380-384
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Forskningsöversikt (refereegranskat)abstract
- Despite intensive research efforts, the aetiology of the majority of chronic lung diseases (CLD) in both, children and adults, remains elusive. Current therapeutic options are limited, providing only symptomatic relief, rather than treating the underlying condition, or preventing its development in the first place. Thus, there is a strong and unmet clinical need for the development of both, novel effective therapies and preventative strategies for CLD. Many studies suggest that modifications of prenatal and/or early postnatal lung development will have important implications for future lung function and risk of CLD throughout life. This view represents a fundamental change of current pathophysiological concepts and treatment paradigms, and holds the potential to develop novel preventative and/or therapeutic strategies. However, for the successful development of such approaches, key questions, such as a clear understanding of underlying mechanisms of impaired lung development, the identification and validation of relevant preclinical models to facilitate translational research, and the development of concepts for correction of aberrant development, all need to be solved. Accordingly, a European Science Foundation Exploratory Workshop was held where clinical, translational and basic research scientists from different disciplines met to discuss potential mechanisms of developmental origins of CLD, and to identify major knowledge gaps in order to delineate a roadmap for future integrative research.
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| 450. |
- Kunkel, E J, et al.
(författare)
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Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
- 2000
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Ingår i: Journal of Experimental Medicine. - 1540-9538. ; 192:5, s. 761-768
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Tidskriftsartikel (refereegranskat)abstract
- The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial lymphocytes and lamina propria lymphocytes migrate to thymus-expressed chemokine (TECK). This attraction is mediated by CC chemokine receptor (CCR)9, a chemoattractant receptor expressed at high levels by essentially all CD4(+) and CD8(+) T lymphocytes in the small intestine. Only a small subset of lymphocytes in the colon are CCR9(+), and lymphocytes from other tissues including tonsils, lung, inflamed liver, normal or inflamed skin, inflamed synovium and synovial fluid, breast milk, and seminal fluid are universally CCR9(-). TECK expression is also restricted to the small intestine: immunohistochemistry reveals that intense anti-TECK reactivity characterizes crypt epithelium in the jejunum and ileum, but not in other epithelia of the digestive tract (including stomach and colon), skin, lung, or salivary gland. These results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses.
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