| 341. |
- Finkel, R. S., et al.
(författare)
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Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy
- 2017
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Ingår i: New England Journal of Medicine. - 0028-4793. ; 377:18, s. 1723-1732
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & para;& para;Spinal muscular atrophy is an autosomal recessive neuromuscular disorder that is caused by an insufficient level of survival motor neuron (SMN) protein. Nusinersen is an antisense oligonucleotide drug that modifies pre-messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.& para;& para;METHODS & para;& para;We conducted a randomized, double-blind, sham-controlled, phase 3 efficacy and safety trial of nusinersen in infants with spinal muscular atrophy. The primary end points were a motor-milestone response (defined according to results on the Hammersmith Infant Neurological Examination) and event-free survival (time to death or the use of permanent assisted ventilation). Secondary end points included over all survival and subgroup analyses of event-free survival according to disease duration at screening. Only the first primary end point was tested in a prespecified interim analysis. To control the overall type I error rate at 0.05, a hierarchical testing strategy was used for the second primary end point and the secondary end points in the final analysis.& para;& para;RESULTS & para;& para;In the interim analysis, a significantly higher percentage of infants in the nusinersen group than in the control group had a motor-milestone response (21 of 51 infants [41 %] vs. 0 of 27 [0%], P<0.001), and this result prompted early termination of the trial. In the final analysis, a significantly higher percentage of infants in the nusinersen group than in the control group had a motor-milestone response (37 of 73 infants [51%] vs. 0 of 37 [0%]), and the likelihood of event-free survival was higher in the nusinersen group than in the control group (hazard ratio for death or the use of permanent assisted ventilation, 0.53; P=0.005). The likelihood of overall survival was higher in the nusinersen group than in the control group (hazard ratio for death, 0.37; P=0.004), and infants with a shorter disease duration at screening were more likely than those with a longer disease duration to benefit from nusinersen. The incidence and severity of adverse events were similar in the two groups.& para;& para;CONCLUSIONS & para;& para;Among infants with spinal muscular atrophy, those who received nusinersen were more likely to be alive and have improvements in motor function than those in the control group. Early treatment may be necessary to maximize the benefit of the drug.
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| 342. |
- Fushitani, Mizuho, et al.
(författare)
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Time-resolved photoelectron imaging of complex resonances in molecular nitrogen
- 2021
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Ingår i: The Journal of chemical physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 154:14
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Tidskriftsartikel (refereegranskat)abstract
- We have used the FERMI free-electron laser to perform time-resolved photoelectron imaging experiments on a complex group of resonances near 15.38 eV in the absorption spectrum of molecular nitrogen, N2, under jet-cooled conditions. The new data complement and extend the earlier work of Fushitani et al. [Opt. Express 27, 19702–19711 (2019)], who recorded time-resolved photoelectron spectra for this same group of resonances. Time-dependent oscillations are observed in both the photoelectron yields and the photoelectron angular distributions, providing insight into the interactions among the resonant intermediate states. In addition, for most states, we observe an exponential decay of the photoelectron yield that depends on the ionic final state. This observation can be rationalized by the different lifetimes for the intermediate states contributing to a particular ionization channel. Although there are nine resonances within the group, we show that by detecting individual photoelectron final states and their angular dependence, we can identify and differentiate quantum pathways within this complex system.
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| 343. |
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| 344. |
- Harada, N., et al.
(författare)
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The ALCHEMI Atlas: Principal Component Analysis Reveals Starburst Evolution in NGC 253
- 2024
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Ingår i: Astrophysical Journal, Supplement Series. - 1538-4365 .- 0067-0049. ; 271:2
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Tidskriftsartikel (refereegranskat)abstract
- Molecular lines are powerful diagnostics of the physical and chemical properties of the interstellar medium (ISM). These ISM properties, which affect future star formation, are expected to differ in starburst galaxies from those of more quiescent galaxies. We investigate the ISM properties in the central molecular zone of the nearby starburst galaxy NGC 253 using the ultrawide millimeter spectral scan survey from the Atacama Large Millimeter/submillimeter Array Large Program ALCHEMI. We present an atlas of velocity-integrated images at a 1.″6 resolution of 148 unblended transitions from 44 species, including the first extragalactic detection of HCNH+ and the first interferometric images of C3H+, NO, and HCS+. We conduct a principal component analysis (PCA) on these images to extract correlated chemical species and to identify key groups of diagnostic transitions. To the best of our knowledge, our data set is currently the largest astronomical set of molecular lines to which PCA has been applied. The PCA can categorize transitions coming from different physical components in NGC 253 such as (i) young starburst tracers characterized by high-excitation transitions of HC3N and complex organic molecules versus tracers of on-going star formation (radio recombination lines) and high-excitation transitions of CCH and CN tracing photodissociation regions, (ii) tracers of cloud-collision-induced shocks (low-excitation transitions of CH3OH, HNCO, HOCO+, and OCS) versus shocks from star formation-induced outflows (high-excitation transitions of SiO), as well as (iii) outflows showing emission from HOC+, CCH, H3O+, CO isotopologues, HCN, HCO+, CS, and CN. Our findings show these intensities vary with galactic dynamics, star formation activities, and stellar feedback.
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| 345. |
- Hasegawa, H., et al.
(författare)
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Magnetic Field Annihilation in a Magnetotail Electron Diffusion Region With Electron-Scale Magnetic Island
- 2022
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 127:7
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Tidskriftsartikel (refereegranskat)abstract
- We present observations in Earth's magnetotail by the Magnetospheric Multiscale spacecraft that are consistent with magnetic field annihilation, rather than magnetic topology change, causing fast magnetic-to-electron energy conversion in an electron-scale current sheet. Multi-spacecraft analysis for the magnetic field reconstruction shows that an electron-scale magnetic island was embedded in the observed electron diffusion region (EDR), suggesting an elongated shape of the EDR. Evidence for the annihilation was revealed in the form of the island growing at a rate much lower than expected for the standard X-type geometry of the EDR, which indicates that magnetic flux injected into the EDR was not ejected from the X-point or accumulated in the island, but was dissipated in the EDR. This energy conversion process is in contrast to that in the standard EDR of a reconnecting current sheet where the energy of antiparallel magnetic fields is mostly converted to electron bulk-flow energy. Fully kinetic simulation also demonstrates that an elongated EDR is subject to the formation of electron-scale magnetic islands in which fast but transient annihilation can occur. Consistent with the observations and simulation, theoretical analysis shows that fast magnetic diffusion can occur in an elongated EDR in the presence of nongyrotropic electron effects. We suggest that the annihilation in elongated EDRs may contribute to the dissipation of magnetic energy in a turbulent collisionless plasma.
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| 346. |
- Hasegawa, H., et al.
(författare)
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Reconstruction of the electron diffusion region observed by the Magnetospheric Multiscale spacecraft : First results
- 2017
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Ingår i: Geophysical Research Letters. - : Blackwell Publishing Ltd. - 0094-8276 .- 1944-8007. ; 44:10, s. 4566-4574
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Tidskriftsartikel (refereegranskat)abstract
- We present first results of the reconstruction of the electron diffusion region (EDR) based on a two-dimensional, incompressible, and inertialess version of the electron magnetohydrodynamics equations. The method is applied to 30 ms resolution magnetic field, and electron moments data taken when the Magnetospheric Multiscale (MMS) spacecraft observed an EDR of near-antiparallel magnetopause reconnection on 16 October 2015. An X-type magnetic field configuration and quadrupolar Hall fields, consistent with the electron inflow and outflow, are successfully recovered. While MMS encountered a region of significant energy dissipation on the magnetospheric side of the sub-ion-scale current sheet, the reconstructions show that the MMS tetrahedron missed the X line by a distance of a few kilometers (~2 electron inertial lengths). The estimated reconnection electric field is 0.42–0.98 mV/m, equivalent to the dimensionless reconnection rate of 0.11–0.25. Signatures of three-dimensional structures and/or time-dependent processes are also identified.
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| 347. |
- Hasegawa, H., et al.
(författare)
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Reconstruction of the Electron Diffusion Region of Magnetotail Reconnection seen by the MMS Spacecraft on 11July 2017
- 2019
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 124:1, s. 122-138
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Tidskriftsartikel (refereegranskat)abstract
- We present results from the reconstruction of the electron diffusion region of magnetotail reconnection observed by the Magnetospheric Multiscale (MMS) spacecraft on 11 July 2017. In the event, the conditions were suited for the reconstruction technique, developed by Sonnerup et al. (2016, https://doi.org/10.1002/2016JA022430), that produces magnetic field and electron streamline maps based on a two-dimensional, time-independent, inertialess form of electron magnetohydrodynamic equation, assuming an approximately symmetric current sheet and negligible guide magnetic field. For such a two-dimensional and steady structure, the X line orientation can be estimated from a method based on Ampere's law using single-spacecraft measurements of the magnetic field and electric current density. Our reconstruction results indicate that although the X point was not captured inside its tetrahedron, MMS approached the X point as close as one electron inertial length similar to 27 km. The opening angle of the recovered separatrix field line, combined with theory, suggests that the dimensionless reconnection rate was 0.17, which is consistent with the measured reconnection electric field 2-4 mV/m. The stagnation point of the reconstructed electron flow is shifted earthward of the X point by similar to 90 km, one possible interpretation of which is discussed. The energy conversion rate j . E' in the electron frame tends to be higher near the stagnation point, consistent with earlier observations and simulations, and is not correlated with the amplitude of broadband electrostatic waves observed in the upper-hybrid frequency range. The latter suggests that the waves did not contribute to energy dissipation in this particular electron diffusion region. Plain Language Summary Magnetic reconnection is a fundamental plasma process that controls transfer of solar wind energy and mass to planetary magnetospheres and causes explosive energy release associated with solar flares and sudden auroral brightening. National Aeronautics and Space Administration's Magnetospheric Multiscale (MMS) mission, which consists of four identical spacecraft launched in March 2015, aims at elucidating how magnetic reconnection works with unprecedented high temporal and spatial resolution measurements of charged particles and electromagnetic fields in space. MMS has been observing the Earth's magnetotail since May 2017 and encountered the central region of magnetic reconnection, called the electron diffusion region, on 11 July 2017. In this study, we present two-dimensional images of this region recovered from the MMS electron and magnetic field measurements, showing that the electron flow pattern in the electron diffusion region is not as simple as predicted by theory. The results provide new insights about the reconnection process in the actual space environment.
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| 348. |
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| 349. |
- Jarzebski, Marcin Pawel, et al.
(författare)
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Developing biodiversity-based solutions for sustainable food systems through transdisciplinary Sustainable Development Goals Labs (SDG-Labs)
- 2023
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Ingår i: Frontiers in Sustainable Food Systems. - 2571-581X. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Although biodiversity is a central component of food systems, conventional food systems have become one of the major drivers of biodiversity loss globally. There is an increasing need to transform food systems to provide sufficient and nutritious food, but with minimal negative impacts on the environment and society. One of the possible avenues to enable the sustainable transformation of food systems might be through the development of locally appropriate biodiversity-based solutions. In this paper we report the insights and lessons learned during the design and implementation of transdisciplinary projects that employed the concept of Sustainable Development Goals labs (SDG-Labs) to create biodiversity-based solutions to transform food systems. The six SDG-Labs outlined in this paper were implemented in Armenia, China, Japan, Madagascar, Thailand, and Uganda. Collectively they developed very diverse biodiversity-based solutions that used different components of biodiversity, ranging from novel cultivation systems with endangered plants, to gardens using tree species for wind breaks, or novel tea-forestry production systems. Beyond their ability to leverage different components of biodiversity to transform local food systems (also conserving biodiversity in the process), all solutions had multiple co-benefits such as climate change adaptation/mitigation and livelihoods generation, among other sustainability domains. Through a Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis we synthesized the experiences gained during the design and implementation of all six SDG-Labs. The findings suggest the great promise of these transdisciplinary approaches for developing solutions at the biodiversity-food-climate nexus. However, this synthesis paper also points to the multiple context-specific challenges that should be overcomed to maximize the potential of SDG-Labs to both enable the sustainable transformation of (local) food systems and/or be scaled up effectively.
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