SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Schaid D) "

Sökning: WFRF:(Schaid D)

  • Resultat 41-43 av 43
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
41.
  • Szulkin, R, et al. (författare)
  • Genome-wide association study of prostate cancer-specific survival
  • 2015
  • Ingår i: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - 1538-7755. ; 24:11, s. 1796-1800
  • Tidskriftsartikel (refereegranskat)
  •  
42.
  •  
43.
  • Yazdani, Azam, et al. (författare)
  • Broadcasters, receivers, functional groups of metabolites, and the link to heart failure by revealing metabolomic network connectivity
  • 2024
  • Ingår i: Metabolomics. - 1573-3882 .- 1573-3890. ; 20:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and Objective : Blood-based small molecule metabolites offer easy accessibility and hold significant potential for insights into health processes, the impact of lifestyle, and genetic variation on disease, enabling precise risk prevention. In a prospective study with records of heart failure (HF) incidence, we present metabolite profiling data from individuals without HF at baseline. Methods : We uncovered the interconnectivity of metabolites using data-driven and causal networks augmented with polygenic factors. Exploring the networks, we identified metabolite broadcasters, receivers, mediators, and subnetworks corresponding to functional classes of metabolites, and provided insights into the link between metabolomic architecture and regulation in health. We incorporated the network structure into the identification of metabolites associated with HF to control the effect of confounding metabolites. Results : We identified metabolites associated with higher and lower risk of HF incidence, such as glycine, ureidopropionic and glycocholic acids, and LPC 18:2. These associations were not confounded by the other metabolites due to uncovering the connectivity among metabolites and adjusting each association for the confounding metabolites. Examples of our findings include the direct influence of asparagine on glycine, both of which were inversely associated with HF. These two metabolites were influenced by polygenic factors and only essential amino acids, which are not synthesized in the human body and are obtained directly from the diet. Conclusion : Metabolites may play a critical role in linking genetic background and lifestyle factors to HF incidence. Revealing the underlying connectivity of metabolites associated with HF strengthens the findings and facilitates studying complex conditions like HF.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 41-43 av 43

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy