| 2121. |
- Schmelz, M., et al.
(författare)
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Active "itch fibers" in chronic pruritus
- 2003
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Ingår i: Neurology. - : Lippincott Williams & Wilkins. - 0028-3878 .- 1526-632X. ; 61:4, s. 564-566
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Tidskriftsartikel (refereegranskat)abstract
- An itch-specific neuronal pathway was recently discovered in healthy humans and animals. Here the authors report that activity in this specific pathway coincides with itch under pathophysiologic conditions in a patient with chronic pruritus. Microneurographic recordings from the symptomatic area revealed spontaneous activity in six single C-fiber afferents that had the characteristic features of "itch fibers." Itch may be caused by activity in a specific subpopulation of C-fiber afferents.
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| 2122. |
- Schmelz, M., et al.
(författare)
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Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
- 2003
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Ingår i: Journal of Neurophysiology. - Washington : The American Physiological Society. - 0022-3077 .- 1522-1598. ; 89:5, s. 2441-2448
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Tidskriftsartikel (refereegranskat)abstract
- Vasoneuroactive substances were applied through intradermal microdialysis membranes and characterized as itch- or pain-inducing in psychophysical experiments. Histamine always provoked itching and rarely pain, capsaicin always pain but never itching. Prostaglandin E[2] (PGE[2]) led preferentially to moderate itching. Serotonin, acetylcholine, and bradykinin induced pain more often than itching. Subsequently the same substances were used in microneurography experiments to characterize the sensitivity profile of human cutaneous C-nociceptors. The responses of 89 mechanoresponsive (CMH, polymodal nociceptors), 52 mechanoinsensitive, histamine-negative (CMi[H][i][s][-]), and 24 mechanoinsensitive, histamine-positive (CMi[H][i][s][+]) units were compared. CMi[H][i][s][+] units were most responsive to histamine and to PGE[2] and less to serotonin, ACh, bradykinin, and capsaicin. CMH units (polymodal nociceptors) and CMi[H][i][s] units showed significantly weaker responses to histamine, PGE[2], and acetylcholine. Capsaicin and bradykinin responses were not significantly different in the two classes of mechano-insensitive units. We conclude that CMi[H][i][s][+]units are "selective," but not "specific" for pruritogenic substances and that the pruritic potency of a mediator increases with its ability to activate CMi[H][i][s][+] units but decreases with activation of CMH and CMi[H][i][s] units.
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| 2123. |
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| 2124. |
- Schmidt, A, et al.
(författare)
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Desmosomes and cytoskeletal architecture in epithelial differentiation: cell type-specific plaque components and intermediate filament anchorage
- 1994
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Ingår i: European Journal of Cell Biology. - 0171-9335. ; 65:2, s. 229-245
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Tidskriftsartikel (refereegranskat)abstract
- Among the diverse kinds of intercellular, plaque-bearing, cadherin-containing junctions, desmosomes (maculae adhaerentes) represent a major type characterized by the presence of specific transmembrane glycoproteins, i.e. desmosomal cadherins of the desmoglein and desmocollin categories, and the cytoplasmic plaque proteins, desmoplakin I and plakoglobin. Recent studies, however, have shown that the composition of desmosomes is not identical in the various normal and tumorous desmosome-forming tissues and cell cultures, including diverse forms of epithelia and carcinomas, meningothelia and meningiomas, myocardium and the lymph node follicle reticulum. Desmosomes can differ in their specific complement of desmogleins, Dsg1-3, and desmocollins, Dsc1a-3b, as well as in the additional presence and in their relative amounts of certain accessory plaque proteins such as desmoplakin II and plakophilin 1, a basic member of the larger plakoglobin family of proteins ("band 6 protein"). Assembly and function of desmosomes are effected by the interaction of the specific complement of desmosomal cadherins with certain cytoplasmic proteins. In particular, the cytoplasmic portions ("tails") of the desmosomal cadherins contain certain domains and amino acid sequence motifs, identified by mutagenesis and transfection assays, that are essential elements in desmosome formation, notably the assembly of plaque proteins, and in the site-specific anchorage of intermediate-sized filaments (IFs) of the cytoskeleton, thereby contributing to the specific intracellular as well as supracellular, i.e. tissue, architecture.
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| 2125. |
- Schmidt, Annette, 1956, et al.
(författare)
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Influence of cold ischemia time on complement activation, neopterin, and cytokine release in liver transplantation.
- 2004
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Ingår i: Transplantation proceedings. - : Elsevier BV. - 0041-1345. ; 36:9, s. 2796-8
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aim of this study was to determine whether a cold ischemia time (CIT) of >12 hours influences the activation of complement as well as the plasma concentrations of neopterin, interleukin (IL)-6, or IL-8 in orthotopic liver transplantation (OLT). PATIENTS AND METHODS: Eighteen consecutive patients undergoing OLT using a veno-venous bypass technique were divided into 2 groups: duration of CIT >12 hours (group 1; n = 11), and CIT <12 hours (group 2; n = 7). Blood samples were drawn preoperatively, 1 minute before, and 120 minutes after reperfusion. RESULTS: Preoperatively, complement split products, neopterin, IL-6, and IL-8 levels did not differ between the groups. At 120 minutes after reperfusion, the concentrations of C3a, SC5b-9, neopterin, IL-6, and IL-8 were significantly increased in both groups compared with the preoperative values or the levels determined 1 minute before reperfusion (P < .05). Patients in group 1 showed significantly higher IL-8 levels at 120 minutes after reperfusion (P < .05). CONCLUSION: Complement is activated and pro-inflammatory cytokines released after reperfusion in OLT using a veno-venous bypass technique, but only IL-8 plasma levels were influenced by the duration of CIT. Therefore, alterations following prolonged CIT seem to not be complement-mediated.
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| 2126. |
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| 2127. |
- Schmidt, AF, et al.
(författare)
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Unravelling the Difference Between Men and Women in Post-CABG Survival
- 2022
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Ingår i: Frontiers in cardiovascular medicine. - : Frontiers Media SA. - 2297-055X. ; 9, s. 768972-
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Tidskriftsartikel (refereegranskat)abstract
- Women have a worse prognosis after coronary artery bypass grafting (CABG) surgery compared to men. We sought to quantify to what extent this difference in post-CABG survival could be attributed to sex itself, or whether this was mediated by difference between men and women at the time of intervention. Additionally, we explored to what extent these effects were homogenous across patient subgroups.MethodsTime to all-cause mortality was available for 102,263 CABG patients, including 20,988 (21%) women, sourced through an individual participant data meta-analysis of five cohort studies. Difference between men and women in survival duration was assessed using Kaplan–Meier estimates, and Cox’s proportional hazards model.ResultsDuring a median follow-up of 5 years, 13,598 (13%) patients died, with women more likely to die than men: female HR 1.20 (95%CI 1.16; 1.25). We found that differences in patient characteristics at the time of CABG procedure mediated this sex effect, and accounting for these resulted in a neutral female HR 0.98 (95%CI 0.94; 1.02). Next we performed a priori defined subgroup analyses of the five most prominent mediators: age, creatinine, peripheral vascular disease, type 2 diabetes, and heart failure. We found that women without peripheral vascular disease (PVD) or women aged 70+, survived longer than men (interaction p-values 0.04 and 6 × 10–5, respectively), with an effect reversal in younger women.ConclusionSex differences in post-CABG survival were readily explained by difference in patient characteristics and comorbidities. Pre-planned analyses revealed patient subgroups (aged 70+, or without PVD) of women that survived longer than men, and a subgroup of younger women with comparatively poorer survival.
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| 2128. |
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| 2129. |
- Schmidt, Bernard, 1981-, et al.
(författare)
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Augmented Reality Approach for a User Interface in a Robotic Production System
- 2022
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Ingår i: SPS2022. - Amsterdam; Berlin; Washington, DC : IOS Press. - 9781643682686 - 9781643682693 ; , s. 240-251
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Konferensbidrag (refereegranskat)abstract
- In a Cyber-physical system, the information flow from the cyber part to the physical part plays a crucial role. This paper presents the work of development and initial testing of an augmented reality approach to provide a user interface for operators that could be a part of a robotic production system. The solution is distributed and includes a communication hub that allows the exchange of data and information between multiple clients e.g. robot controllers, an optimization platform, and visualization devices. The main contributions of the presented work are visualization of optimization results and visualization of information obtained from the robot controller and the integrated communication framework. The paper also presents challenges faced during the development work and opportunities related to the presented approach. The implemented interface uses HoloLens 2 mixed reality device to visualize in real-time information obtained from a robot controller as well as from simulation. Information regarding the placement of work objects and targets or currently executed lines of code can be useful for robotic cell programmers and commissioning teams to validate robot programs and to select more optimal solutions toward sustainable manufacturing. The operator can simulate the execution of the robot program and visualize it by overlying the robot cell with the 3D model of the simulated robot. Moreover, visualization of future robot motion could support human-robot collaboration. Furthermore, the interface allows providing the user with details from multi-objective optimization performed on a digital twin of the robotic cell with the aim to reduce cycle time and energy consumption. It allows visualizing selected scenarios to support decision-making by allowing comparison of proposed solutions and the initial one. The visualization includes cell layout, robot path, cycle time, robot energy consumption. The presented approach is demonstrated in industry-inspired cases and with the use of an industrial ABB robot.
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| 2130. |
- Schmidt, Bernard, 1981-, et al.
(författare)
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Integration of events and offline measurement data from a population of similar entities for condition monitoring
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, an approach for integration of data from different sources and from a population of similar monitored entities is presented with evaluation procedure based on multiple machine learning methods that allows selection of a proper combination of methods for data integration and feature selection. It is exemplified on the real-world case from manufacturing industry with application to double ball-bar measurement from a population of machine tools. Historical data from the period of four years from a population of 29 similar multitask machine tools are analysed. Several feature selection methods are evaluated. Finally, simple economic evaluation is presented with application to proposed condition based approach. With assumed parameters, potential improvement in long term of 6 times reduced amount of unplanned stops and 40% reduced cost has been indicated with respect to optimal time based replacement policy.
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